Gene name: TIF2
Reference locus (S288C): YJL138C
Gene biotype: protein_coding
Description: Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication
Top 10 interactors (score): TIF3 (0.999); TIF4631 (0.999); TIF4632 (0.999); CDC33 (0.999); TIF1 (0.998); PRT1 (0.995); EFT1 (0.987); TIF11 (0.985); TEF1 (0.982); PAB1 (0.981); FUN12 (0.975); SUI2 (0.975); TIF34 (0.961); TEF2 (0.959); RPG1 (0.956); EFT2 (0.954); RPS5 (0.951); ASC1 (0.949); RPS3 (0.945); RPS20 (0.944)
Homologues (species, bitscore): EIF4A1 (Homo sapiens, 537.3); Eif4a1 (Mus musculus, 537.3); eif4a2 (Danio rerio, 530.4); eif4a1 (Xenopus tropicalis, 533.9); eIF-4a (Drosophila melanogaster, 538.5); inf-1 (Caenorhabditis elegans, 535.0); EIF4A-III (Arabidopsis thaliana, 502.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:470735-471922:+ | gene-YJL138C_BG1 | rna-NM_001181571.1_BG1 | cds-NP_012397.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:153885-155070:- | gene-YJL138C_Bruggeman | rna-NM_001181571.1_Bruggeman | cds-NP_012397.1_Bruggeman | 98.7 | 99.8 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:157673-158858:- | gene-YJL138C_CAT1 | rna-NM_001181571.1_CAT1 | cds-NP_012397.1_CAT1 | 98.7 | 99.8 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:172183-173369:- | gene-YJL138C_CBS436 | rna-NM_001181571.1_CBS436 | cds-NP_012397.1_CBS436 | 71.3 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:135892-137161:- | gene-YJL138C_CENPK1137D | rna-NM_001181571.1_CENPK1137D | cds-NP_012397.1_CENPK1137D | 93.3 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000099.1:32615-33801:- | gene-YJL138C_JAY291 | rna-NM_001181571.1_JAY291 | cds-NP_012397.1_JAY291 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:156154-157339:- | gene-YJL138C_MUCL30387 | rna-NM_001181571.1_MUCL30387 | cds-NP_012397.1_MUCL30387 | 98.7 | 99.8 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:146133-147309:- | gene-YJL138C_MUCL39482 | rna-NM_001181571.1_MUCL39482 | cds-NP_012397.1_MUCL39482 | 95.8 | 98.6 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:151945-153130:- | gene-YJL138C_MUCL42920 | rna-NM_001181571.1_MUCL42920 | cds-NP_012397.1_MUCL42920 | 98.6 | 99.8 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:153483-154670:- | gene-YJL138C_NCIM3186 | rna-NM_001181571.1_NCIM3186 | cds-NP_012397.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:157591-158778:- | gene-YJL138C_PE2H3 | rna-NM_001181571.1_PE2H3 | cds-NP_012397.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:157234-158421:- | gene-YJL138C_PE2H4 | rna-NM_001181571.1_PE2H4 | cds-NP_012397.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:153504-154691:- | gene-YJL138C_S288C | rna-NM_001181571.1_S288C | cds-NP_012397.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000215.1:1-1109:- | gene-YJL138C_SA1 | rna-NM_001181571.1_SA1 | cds-NP_012397.1_SA1 | 93.3 | 93.3 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:131916-133103:- | gene-YJL138C_ZTW1 | rna-NM_001181571.1_ZTW1 | cds-NP_012397.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:157195-158382:- | gene-YJL138C_Sparadoxus | rna-NM_001181571.1_Sparadoxus | cds-NP_012397.1_Sparadoxus | 96.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |