Gene name: TIF1
Reference locus (S288C): YKR059W
Gene biotype: protein_coding
Description: Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
Top 10 interactors (score): TIF4631 (0.999); TIF4632 (0.999); CDC33 (0.999); TIF3 (0.999); PRT1 (0.998); TIF2 (0.998); TIF11 (0.995); SUI2 (0.993); PAB1 (0.993); EFT2 (0.984); RPG1 (0.984); TIF34 (0.981); SUI3 (0.978); EFT1 (0.973); FUN12 (0.973); DHR2 (0.966); TEF1 (0.965); RPS3 (0.964); TEF2 (0.963); NIP1 (0.957)
Homologues (species, bitscore): EIF4A1 (Homo sapiens, 537.3); Eif4a1 (Mus musculus, 537.3); eif4a2 (Danio rerio, 530.4); eif4a1 (Xenopus tropicalis, 533.9); eIF-4a (Drosophila melanogaster, 538.5); inf-1 (Caenorhabditis elegans, 535.0); EIF4A-III (Arabidopsis thaliana, 502.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:540582-541968:+ | gene-YKR059W_AKU4011 | rna-NM_001179849.3_AKU4011 | cds-NP_012985.3_AKU4011 | 78.3 | 95.7 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:102056-103243:- | gene-YKR059W_BG1 | rna-NM_001179849.3_BG1 | cds-NP_012985.3_BG1 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:553322-554708:+ | gene-YKR059W_CBS1585 | rna-NM_001179849.3_CBS1585 | cds-NP_012985.3_CBS1585 | 78.3 | 95.7 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:551854-553041:+ | gene-YKR059W_CBS436 | rna-NM_001179849.3_CBS436 | cds-NP_012985.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | MBVQ01000084.1:1-1109:- | gene-YKR059W_CBS6412 | rna-NM_001179849.3_CBS6412 | cds-NP_012985.3_CBS6412 | 93.2 | 93.3 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:553102-554277:+ | gene-YKR059W_CBS6413 | rna-NM_001179849.3_CBS6413 | cds-NP_012985.3_CBS6413 | 95.5 | 98.7 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:554643-555830:+ | gene-YKR059W_CENPK1137D | rna-NM_001179849.3_CENPK1137D | cds-NP_012985.3_CENPK1137D | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | MBWB01000072.1:1-1109:+ | gene-YKR059W_EthanolRed | rna-NM_001179849.3_EthanolRed | cds-NP_012985.3_EthanolRed | 93.2 | 93.3 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:554000-555175:+ | gene-YKR059W_FaliES1 | rna-NM_001179849.3_FaliES1 | cds-NP_012985.3_FaliES1 | 95.5 | 98.7 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:557220-558405:+ | gene-YKR059W_MUCL30388 | rna-NM_001179849.3_MUCL30388 | cds-NP_012985.3_MUCL30388 | 98.4 | 99.8 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:554976-556163:+ | gene-YKR059W_NCIM3186 | rna-NM_001179849.3_NCIM3186 | cds-NP_012985.3_NCIM3186 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:552824-554001:+ | gene-YKR059W_NCYC1407 | rna-NM_001179849.3_NCYC1407 | cds-NP_012985.3_NCYC1407 | 95.9 | 98.9 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:577931-579118:+ | gene-YKR059W_PE2H3 | rna-NM_001179849.3_PE2H3 | cds-NP_012985.3_PE2H3 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:562326-563513:+ | gene-YKR059W_PE2H4 | rna-NM_001179849.3_PE2H4 | cds-NP_012985.3_PE2H4 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:554987-556174:+ | gene-YKR059W_S288C | rna-NM_001179849.3_S288C | cds-NP_012985.3_S288C | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:553239-554414:+ | gene-YKR059W_ThermosaccDry | rna-NM_001179849.3_ThermosaccDry | cds-NP_012985.3_ThermosaccDry | 95.5 | 98.7 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:552999-554184:+ | gene-YKR059W_VR1 | rna-NM_001179849.3_VR1 | cds-NP_012985.3_VR1 | 98.4 | 99.8 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:550969-552156:+ | gene-YKR059W_ZTW1 | rna-NM_001179849.3_ZTW1 | cds-NP_012985.3_ZTW1 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:576307-577494:+ | gene-YKR059W_Sparadoxus | rna-NM_001179849.3_Sparadoxus | cds-NP_012985.3_Sparadoxus | 96.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |