Gene name: THI3
Reference locus (S288C): YDL080C
Gene biotype: protein_coding
Description: Thiamine metabolism regulatory protein THI3; Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected
Top 10 interactors (score): THI2 (0.98); SFA1 (0.973); BAT2 (0.968); PDC2 (0.967); PDB1 (0.957); PYK2 (0.955); PDA1 (0.938); CDC19 (0.937); LPD1 (0.932); ADH6 (0.931); ADH7 (0.927); ADH4 (0.923); ADH2 (0.918); ADH1 (0.91); ADH5 (0.909); BAT1 (0.904); ADH3 (0.903); TKL1 (0.858); PGI1 (0.849); TKL2 (0.84)
Homologues (species, bitscore): HACL1 (Homo sapiens, 75.9); Hacl1 (Mus musculus, 67.0); hacl1 (Danio rerio, 70.1); hacl1 (Xenopus tropicalis, 73.9); CG11208 (Drosophila melanogaster, 64.7); B0334.3 (Caenorhabditis elegans, 60.5); PDC3 (Arabidopsis thaliana, 253.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:295258-297086:- | gene-YDL080C_AKU4011 | rna-NM_001180139.1_AKU4011 | cds-NP_010203.1_AKU4011 | 98.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:252863-254691:+ | gene-YDL080C_BG1 | rna-NM_001180139.1_BG1 | cds-NP_010203.1_BG1 | 99.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:312925-314753:- | gene-YDL080C_Bruggeman | rna-NM_001180139.1_Bruggeman | cds-NP_010203.1_Bruggeman | 99.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:309415-311243:- | gene-YDL080C_CAT1 | rna-NM_001180139.1_CAT1 | cds-NP_010203.1_CAT1 | 99.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:293530-295358:- | gene-YDL080C_CBS1585 | rna-NM_001180139.1_CBS1585 | cds-NP_010203.1_CBS1585 | 98.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:310194-312022:- | gene-YDL080C_CBS436 | rna-NM_001180139.1_CBS436 | cds-NP_010203.1_CBS436 | 99.6 | 99.9 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:291957-293785:- | gene-YDL080C_CBS6412 | rna-NM_001180139.1_CBS6412 | cds-NP_010203.1_CBS6412 | 98.8 | 99.9 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:311583-313411:- | gene-YDL080C_CBS6413 | rna-NM_001180139.1_CBS6413 | cds-NP_010203.1_CBS6413 | 98.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:309465-311294:- | gene-YDL080C_CENPK1137D | rna-NM_001180139.1_CENPK1137D | cds-NP_010203.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:306292-308120:- | gene-YDL080C_EthanolRed | rna-NM_001180139.1_EthanolRed | cds-NP_010203.1_EthanolRed | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:312264-314092:- | gene-YDL080C_FaliES1 | rna-NM_001180139.1_FaliES1 | cds-NP_010203.1_FaliES1 | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:82315-84143:- | gene-YDL080C_JAY291 | rna-NM_001180139.1_JAY291 | cds-NP_010203.1_JAY291 | 99.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:310441-312269:- | gene-YDL080C_MUCL30387 | rna-NM_001180139.1_MUCL30387 | cds-NP_010203.1_MUCL30387 | 99.5 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:301467-303295:- | gene-YDL080C_MUCL30388 | rna-NM_001180139.1_MUCL30388 | cds-NP_010203.1_MUCL30388 | 99.4 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:294635-296463:- | gene-YDL080C_MUCL39482 | rna-NM_001180139.1_MUCL39482 | cds-NP_010203.1_MUCL39482 | 98.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:216642-218471:- | gene-YDL080C_MUCL42920 | rna-NM_001180139.1_MUCL42920 | cds-NP_010203.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:310565-312394:- | gene-YDL080C_NCIM3186 | rna-NM_001180139.1_NCIM3186 | cds-NP_010203.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:294649-296477:- | gene-YDL080C_NCYC1407 | rna-NM_001180139.1_NCYC1407 | cds-NP_010203.1_NCYC1407 | 98.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:301433-303261:- | gene-YDL080C_PE2H3 | rna-NM_001180139.1_PE2H3 | cds-NP_010203.1_PE2H3 | 99.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:301430-303258:- | gene-YDL080C_PE2H4 | rna-NM_001180139.1_PE2H4 | cds-NP_010203.1_PE2H4 | 99.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:310642-312471:- | gene-YDL080C_S288C | rna-NM_001180139.1_S288C | cds-NP_010203.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:122449-124277:+ | gene-YDL080C_SA1 | rna-NM_001180139.1_SA1 | cds-NP_010203.1_SA1 | 99.2 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:311775-313603:- | gene-YDL080C_ThermosaccDry | rna-NM_001180139.1_ThermosaccDry | cds-NP_010203.1_ThermosaccDry | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:313849-315677:- | gene-YDL080C_VR1 | rna-NM_001180139.1_VR1 | cds-NP_010203.1_VR1 | 99.5 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:309690-311518:- | gene-YDL080C_ZTW1 | rna-NM_001180139.1_ZTW1 | cds-NP_010203.1_ZTW1 | 98.9 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:311813-313641:- | gene-YDL080C_Sparadoxus | rna-NM_001180139.1_Sparadoxus | cds-NP_010203.1_Sparadoxus | 91.2 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |