Gene name: TCB3
Reference locus (S288C): YML072C
Gene biotype: protein_coding
Description: Tricalbin-3; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; Belongs to the tricalbin family
Top 10 interactors (score): IST2 (0.917); SCS2 (0.876); SCS22 (0.81); SAC1 (0.73); TCB1 (0.729); FLC2 (0.71); YGR069W (0.691); YMR295C (0.674); MMR1 (0.652); YGR130C (0.592); TCB2 (0.578); N1795 (0.568); RTN1 (0.566); YTA6 (0.565); OSH6 (0.559); PST2 (0.525); ICE2 (0.525); FLC1 (0.515); BUD9 (0.508); GSC2 (0.495)
Homologues (species, bitscore): ESYT1 (Homo sapiens, 80.5); Esyt1 (Mus musculus, 87.4); esyt1a (Danio rerio, 84.7); esyt1 (Xenopus tropicalis, 81.3); Esyt2 (Drosophila melanogaster, 98.2); esyt-2 (Caenorhabditis elegans, 65.9); SYTC (Arabidopsis thaliana, 123.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:118463-123100:- | gene-YML072C_AKU4011 | rna-NM_001182431.1_AKU4011 | cds-NP_013639.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:353019-357656:+ | gene-YML072C_BG1 | rna-NM_001182431.1_BG1 | cds-NP_013639.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:124625-129262:- | gene-YML072C_Bruggeman | rna-NM_001182431.1_Bruggeman | cds-NP_013639.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:126299-130936:- | gene-YML072C_CAT1 | rna-NM_001182431.1_CAT1 | cds-NP_013639.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:118472-123109:- | gene-YML072C_CBS1585 | rna-NM_001182431.1_CBS1585 | cds-NP_013639.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:124393-129030:- | gene-YML072C_CBS436 | rna-NM_001182431.1_CBS436 | cds-NP_013639.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:119180-123817:- | gene-YML072C_CBS6412 | rna-NM_001182431.1_CBS6412 | cds-NP_013639.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:117655-122292:- | gene-YML072C_CBS6413 | rna-NM_001182431.1_CBS6413 | cds-NP_013639.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:119452-124089:- | gene-YML072C_CENPK1137D | rna-NM_001182431.1_CENPK1137D | cds-NP_013639.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:118738-123375:- | gene-YML072C_EthanolRed | rna-NM_001182431.1_EthanolRed | cds-NP_013639.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:119245-123882:- | gene-YML072C_FaliES1 | rna-NM_001182431.1_FaliES1 | cds-NP_013639.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000366.1:33209-37846:+ | gene-YML072C_JAY291 | rna-NM_001182431.1_JAY291 | cds-NP_013639.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:123155-127792:- | gene-YML072C_MUCL30387 | rna-NM_001182431.1_MUCL30387 | cds-NP_013639.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:126295-130932:- | gene-YML072C_MUCL30388 | rna-NM_001182431.1_MUCL30388 | cds-NP_013639.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:118483-123120:- | gene-YML072C_MUCL39482 | rna-NM_001182431.1_MUCL39482 | cds-NP_013639.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:123885-128522:- | gene-YML072C_MUCL42920 | rna-NM_001182431.1_MUCL42920 | cds-NP_013639.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:124684-129321:- | gene-YML072C_NCIM3186 | rna-NM_001182431.1_NCIM3186 | cds-NP_013639.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:119278-123915:- | gene-YML072C_NCYC1407 | rna-NM_001182431.1_NCYC1407 | cds-NP_013639.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:124653-129290:- | gene-YML072C_PE2H3 | rna-NM_001182431.1_PE2H3 | cds-NP_013639.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:124570-129207:- | gene-YML072C_PE2H4 | rna-NM_001182431.1_PE2H4 | cds-NP_013639.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:124730-129367:- | gene-YML072C_S288C | rna-NM_001182431.1_S288C | cds-NP_013639.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000041.1:54877-59514:+ | gene-YML072C_SA1 | rna-NM_001182431.1_SA1 | cds-NP_013639.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:118537-123174:- | gene-YML072C_ThermosaccDry | rna-NM_001182431.1_ThermosaccDry | cds-NP_013639.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:122918-127555:- | gene-YML072C_VR1 | rna-NM_001182431.1_VR1 | cds-NP_013639.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:98072-102709:- | gene-YML072C_ZTW1 | rna-NM_001182431.1_ZTW1 | cds-NP_013639.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:129334-133971:- | gene-YML072C_Sparadoxus | rna-NM_001182431.1_Sparadoxus | cds-NP_013639.1_Sparadoxus | 90.2 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |