Gene name: TCB2
Reference locus (S288C): YNL087W
Gene biotype: protein_coding
Description: Tricalbin-2; ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog, TCB1, that arose from the whole genome duplication
Top 10 interactors (score): IST2 (0.881); SCS2 (0.853); SCS22 (0.811); YNL089C (0.78); YNL095C (0.747); LNP1 (0.705); SHE2 (0.691); MRPL11 (0.679); OLI1 (0.633); YOP1 (0.624); YTA6 (0.621); RIM21 (0.616); YNL092W (0.614); SEC3 (0.587); NVJ2 (0.579); TCB3 (0.578); ICE2 (0.574); NST1 (0.574); SNN1 (0.572); EXO84 (0.56)
Homologues (species, bitscore): ESYT1 (Homo sapiens, 72.4); Esyt1 (Mus musculus, 77.0); esyt2b (Danio rerio, 86.7); esyt1 (Xenopus tropicalis, 72.0); Esyt2 (Drosophila melanogaster, 73.6); esyt-2 (Caenorhabditis elegans, 68.9); SYTC (Arabidopsis thaliana, 110.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:456057-459593:+ | gene-YNL087W_AKU4011 | rna-NM_001182925.1_AKU4011 | cds-NP_014312.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:360143-363679:+ | gene-YNL087W_BG1 | rna-NM_001182925.1_BG1 | cds-NP_014312.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:466778-470314:+ | gene-YNL087W_Bruggeman | rna-NM_001182925.1_Bruggeman | cds-NP_014312.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:509804-513340:+ | gene-YNL087W_CAT1 | rna-NM_001182925.1_CAT1 | cds-NP_014312.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:456727-460263:+ | gene-YNL087W_CBS1585 | rna-NM_001182925.1_CBS1585 | cds-NP_014312.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:525119-528655:+ | gene-YNL087W_CBS436 | rna-NM_001182925.1_CBS436 | cds-NP_014312.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:451823-455359:+ | gene-YNL087W_CBS6412 | rna-NM_001182925.1_CBS6412 | cds-NP_014312.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:453139-456675:+ | gene-YNL087W_CBS6413 | rna-NM_001182925.1_CBS6413 | cds-NP_014312.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:456235-459771:+ | gene-YNL087W_CENPK1137D | rna-NM_001182925.1_CENPK1137D | cds-NP_014312.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:458883-462419:+ | gene-YNL087W_EthanolRed | rna-NM_001182925.1_EthanolRed | cds-NP_014312.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:449412-452948:+ | gene-YNL087W_FaliES1 | rna-NM_001182925.1_FaliES1 | cds-NP_014312.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000317.1:20650-24186:- | gene-YNL087W_JAY291 | rna-NM_001182925.1_JAY291 | cds-NP_014312.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:462954-466490:+ | gene-YNL087W_MUCL30387 | rna-NM_001182925.1_MUCL30387 | cds-NP_014312.1_MUCL30387 | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:498326-501862:+ | gene-YNL087W_MUCL30388 | rna-NM_001182925.1_MUCL30388 | cds-NP_014312.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:454131-457667:+ | gene-YNL087W_MUCL39482 | rna-NM_001182925.1_MUCL39482 | cds-NP_014312.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:458070-461606:+ | gene-YNL087W_MUCL42920 | rna-NM_001182925.1_MUCL42920 | cds-NP_014312.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:462380-465916:+ | gene-YNL087W_NCIM3186 | rna-NM_001182925.1_NCIM3186 | cds-NP_014312.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:456179-459715:+ | gene-YNL087W_NCYC1407 | rna-NM_001182925.1_NCYC1407 | cds-NP_014312.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:459418-462954:+ | gene-YNL087W_PE2H3 | rna-NM_001182925.1_PE2H3 | cds-NP_014312.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:454493-458029:+ | gene-YNL087W_PE2H4 | rna-NM_001182925.1_PE2H4 | cds-NP_014312.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:462411-465947:+ | gene-YNL087W_S288C | rna-NM_001182925.1_S288C | cds-NP_014312.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000024.1:47356-50892:+ | gene-YNL087W_SA1 | rna-NM_001182925.1_SA1 | cds-NP_014312.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:450287-453823:+ | gene-YNL087W_ThermosaccDry | rna-NM_001182925.1_ThermosaccDry | cds-NP_014312.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:469398-472934:+ | gene-YNL087W_VR1 | rna-NM_001182925.1_VR1 | cds-NP_014312.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:359636-363172:+ | gene-YNL087W_ZTW1 | rna-NM_001182925.1_ZTW1 | cds-NP_014312.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:465801-469337:+ | gene-YNL087W_Sparadoxus | rna-NM_001182925.1_Sparadoxus | cds-NP_014312.1_Sparadoxus | 90.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |