Gene name: TCB1
Reference locus (S288C): YOR086C
Gene biotype: protein_coding
Description: Tricalbin-1; Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication; Belongs to the tricalbin family
Top 10 interactors (score): SCS2 (0.944); IST2 (0.931); SCS22 (0.919); SAC1 (0.73); TCB3 (0.729); MOH1 (0.686); NVJ2 (0.677); ICE2 (0.674); OLI1 (0.639); RIT1 (0.62); MRPL11 (0.614); YTA6 (0.575); RIM21 (0.546); RTN1 (0.528); YGR266W (0.526); SAL1 (0.521); SNN1 (0.52); NUM1 (0.499); DPM1 (0.492); SWH1 (0.481)
Homologues (species, bitscore): ESYT1 (Homo sapiens, 73.6); Esyt1 (Mus musculus, 92.0); mctp1b (Danio rerio, 75.5); mctp2 (Xenopus tropicalis, 69.7); Syt1 (Drosophila melanogaster, 65.1); esyt-2 (Caenorhabditis elegans, 74.7); SYTC (Arabidopsis thaliana, 100.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:467571-471131:- | gene-YOR086C_AKU4011 | rna-NM_001183505.1_AKU4011 | cds-NP_014729.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000171.1:108543-112103:+ | gene-YOR086C_BG1 | rna-NM_001183505.1_BG1 | cds-NP_014729.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:470292-473852:- | gene-YOR086C_Bruggeman | rna-NM_001183505.1_Bruggeman | cds-NP_014729.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:469073-472633:- | gene-YOR086C_CAT1 | rna-NM_001183505.1_CAT1 | cds-NP_014729.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:462290-465850:- | gene-YOR086C_CBS1585 | rna-NM_001183505.1_CBS1585 | cds-NP_014729.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:467085-470645:- | gene-YOR086C_CBS436 | rna-NM_001183505.1_CBS436 | cds-NP_014729.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:461580-465140:- | gene-YOR086C_CBS6412 | rna-NM_001183505.1_CBS6412 | cds-NP_014729.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:468897-472457:- | gene-YOR086C_CBS6413 | rna-NM_001183505.1_CBS6413 | cds-NP_014729.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:483245-486805:- | gene-YOR086C_CENPK1137D | rna-NM_001183505.1_CENPK1137D | cds-NP_014729.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:464105-467665:- | gene-YOR086C_EthanolRed | rna-NM_001183505.1_EthanolRed | cds-NP_014729.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:467612-471172:- | gene-YOR086C_FaliES1 | rna-NM_001183505.1_FaliES1 | cds-NP_014729.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000231.1:798-4358:+ | gene-YOR086C_JAY291 | rna-NM_001183505.1_JAY291 | cds-NP_014729.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:475074-478634:- | gene-YOR086C_MUCL30387 | rna-NM_001183505.1_MUCL30387 | cds-NP_014729.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:479729-483289:- | gene-YOR086C_MUCL30388 | rna-NM_001183505.1_MUCL30388 | cds-NP_014729.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:470005-473565:- | gene-YOR086C_MUCL39482 | rna-NM_001183505.1_MUCL39482 | cds-NP_014729.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:485549-489109:- | gene-YOR086C_MUCL42920 | rna-NM_001183505.1_MUCL42920 | cds-NP_014729.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:483108-486668:- | gene-YOR086C_NCIM3186 | rna-NM_001183505.1_NCIM3186 | cds-NP_014729.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:476677-480237:- | gene-YOR086C_NCYC1407 | rna-NM_001183505.1_NCYC1407 | cds-NP_014729.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:475345-478905:- | gene-YOR086C_PE2H3 | rna-NM_001183505.1_PE2H3 | cds-NP_014729.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:485721-489281:- | gene-YOR086C_PE2H4 | rna-NM_001183505.1_PE2H4 | cds-NP_014729.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:483219-486779:- | gene-YOR086C_S288C | rna-NM_001183505.1_S288C | cds-NP_014729.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000091.1:827-4387:+ | gene-YOR086C_SA1 | rna-NM_001183505.1_SA1 | cds-NP_014729.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:466768-470328:- | gene-YOR086C_ThermosaccDry | rna-NM_001183505.1_ThermosaccDry | cds-NP_014729.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:468265-471825:- | gene-YOR086C_VR1 | rna-NM_001183505.1_VR1 | cds-NP_014729.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:200762-204322:- | gene-YOR086C_ZTW1 | rna-NM_001183505.1_ZTW1 | cds-NP_014729.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:472367-475927:- | gene-YOR086C_Sparadoxus | rna-NM_001183505.1_Sparadoxus | cds-NP_014729.1_Sparadoxus | 90.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |