Gene name: SWE1
Reference locus (S288C): YJL187C
Gene biotype: protein_coding
Description: Mitosis inhibitor protein kinase SWE1; Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
Top 10 interactors (score): CDC28 (0.999); CLB2 (0.999); HSL7 (0.999); MIH1 (0.999); CDC5 (0.998); CLB1 (0.996); HSL1 (0.991); CAK1 (0.991); PHO85 (0.984); GIN4 (0.979); CHK1 (0.978); CDC55 (0.977); MEC1 (0.973); CLB5 (0.964); CLB3 (0.959); MET30 (0.957); CKS1 (0.955); CDC14 (0.954); SKP1 (0.943); CLB6 (0.943)
Homologues (species, bitscore): PKMYT1 (Homo sapiens, 126.3); Pkmyt1 (Mus musculus, 126.7); pkmyt1 (Danio rerio, 134.0); pkmyt1 (Xenopus tropicalis, 133.7); Myt1 (Drosophila melanogaster, 124.8); wee-1.3 (Caenorhabditis elegans, 114.0); NEK5 (Arabidopsis thaliana, 115.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:65196-67655:- | gene-YJL187C_AKU4011 | rna-NM_001181620.1_AKU4011 | cds-NP_012348.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000181.1:42515-44983:- | gene-YJL187C_BG1 | rna-NM_001181620.1_BG1 | cds-NP_012348.1_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:77019-79487:- | gene-YJL187C_Bruggeman | rna-NM_001181620.1_Bruggeman | cds-NP_012348.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:80232-82700:- | gene-YJL187C_CAT1 | rna-NM_001181620.1_CAT1 | cds-NP_012348.1_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:70831-73290:- | gene-YJL187C_CBS1585 | rna-NM_001181620.1_CBS1585 | cds-NP_012348.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:95584-98052:- | gene-YJL187C_CBS436 | rna-NM_001181620.1_CBS436 | cds-NP_012348.1_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:67313-69772:- | gene-YJL187C_CBS6412 | rna-NM_001181620.1_CBS6412 | cds-NP_012348.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:68306-70765:- | gene-YJL187C_CBS6413 | rna-NM_001181620.1_CBS6413 | cds-NP_012348.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:59267-61740:- | gene-YJL187C_CENPK1137D | rna-NM_001181620.1_CENPK1137D | cds-NP_012348.1_CENPK1137D | 98.5 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:69494-71953:- | gene-YJL187C_EthanolRed | rna-NM_001181620.1_EthanolRed | cds-NP_012348.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:74774-77233:- | gene-YJL187C_FaliES1 | rna-NM_001181620.1_FaliES1 | cds-NP_012348.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000164.1:41504-43972:+ | gene-YJL187C_JAY291 | rna-NM_001181620.1_JAY291 | cds-NP_012348.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:78747-81215:- | gene-YJL187C_MUCL30387 | rna-NM_001181620.1_MUCL30387 | cds-NP_012348.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:74908-77376:- | gene-YJL187C_MUCL30388 | rna-NM_001181620.1_MUCL30388 | cds-NP_012348.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:69573-72032:- | gene-YJL187C_MUCL39482 | rna-NM_001181620.1_MUCL39482 | cds-NP_012348.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:74175-76643:- | gene-YJL187C_MUCL42920 | rna-NM_001181620.1_MUCL42920 | cds-NP_012348.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:76782-79241:- | gene-YJL187C_NCIM3186 | rna-NM_001181620.1_NCIM3186 | cds-NP_012348.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:68184-70643:- | gene-YJL187C_NCYC1407 | rna-NM_001181620.1_NCYC1407 | cds-NP_012348.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:80881-83349:- | gene-YJL187C_PE2H3 | rna-NM_001181620.1_PE2H3 | cds-NP_012348.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:80520-82988:- | gene-YJL187C_PE2H4 | rna-NM_001181620.1_PE2H4 | cds-NP_012348.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:76803-79262:- | gene-YJL187C_S288C | rna-NM_001181620.1_S288C | cds-NP_012348.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:74609-77077:+ | gene-YJL187C_SA1 | rna-NM_001181620.1_SA1 | cds-NP_012348.1_SA1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:67966-70425:- | gene-YJL187C_ThermosaccDry | rna-NM_001181620.1_ThermosaccDry | cds-NP_012348.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:74839-77307:- | gene-YJL187C_VR1 | rna-NM_001181620.1_VR1 | cds-NP_012348.1_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:55552-58011:- | gene-YJL187C_ZTW1 | rna-NM_001181620.1_ZTW1 | cds-NP_012348.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:79938-82403:- | gene-YJL187C_Sparadoxus | rna-NM_001181620.1_Sparadoxus | cds-NP_012348.1_Sparadoxus | 88.6 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |