Gene name: SUP35
Reference locus (S288C): YDR172W
Gene biotype: protein_coding
Description: Eukaryotic peptide chain release factor GTP-binding subunit; Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that modifies cellular fitness, alters translational fidelity by affecting reading frame selection, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of [PSI(+)]
Top 10 interactors (score): PAB1 (0.999); SUP45 (0.999); NAM7 (0.999); HSP104 (0.999); DOM34 (0.997); SSA1 (0.997); NMD2 (0.996); UPF3 (0.995); RNQ1 (0.995); RLI1 (0.991); YDJ1 (0.984); SIS1 (0.983); URE2 (0.979); CAM1 (0.973); TEF4 (0.972); RPG1 (0.968); NEW1 (0.965); ITT1 (0.964); MTQ2 (0.962); ADE1 (0.961)
Homologues (species, bitscore): GSPT1 (Homo sapiens, 531.2); Gspt2 (Mus musculus, 530.4); gspt1l (Danio rerio, 525.0); gspt1 (Xenopus tropicalis, 473.8); Elf (Drosophila melanogaster, 518.8); erfa-3 (Caenorhabditis elegans, 474.2); AT1G18070 (Arabidopsis thaliana, 497.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:776860-778917:+ | gene-YDR172W_AKU4011 | rna-NM_001180479.3_AKU4011 | cds-NP_010457.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:346885-348942:- | gene-YDR172W_BG1 | rna-NM_001180479.3_BG1 | cds-NP_010457.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:809279-811336:+ | gene-YDR172W_Bruggeman | rna-NM_001180479.3_Bruggeman | cds-NP_010457.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:796526-798583:+ | gene-YDR172W_CAT1 | rna-NM_001180479.3_CAT1 | cds-NP_010457.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:767227-769284:+ | gene-YDR172W_CBS1585 | rna-NM_001180479.3_CBS1585 | cds-NP_010457.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:796190-798247:+ | gene-YDR172W_CBS436 | rna-NM_001180479.3_CBS436 | cds-NP_010457.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:764032-766089:+ | gene-YDR172W_CBS6412 | rna-NM_001180479.3_CBS6412 | cds-NP_010457.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:794555-796612:+ | gene-YDR172W_CBS6413 | rna-NM_001180479.3_CBS6413 | cds-NP_010457.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:807133-809190:+ | gene-YDR172W_CENPK1137D | rna-NM_001180479.3_CENPK1137D | cds-NP_010457.3_CENPK1137D | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:777613-779670:+ | gene-YDR172W_EthanolRed | rna-NM_001180479.3_EthanolRed | cds-NP_010457.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:785825-787882:+ | gene-YDR172W_FaliES1 | rna-NM_001180479.3_FaliES1 | cds-NP_010457.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000068.1:61480-63537:- | gene-YDR172W_JAY291 | rna-NM_001180479.3_JAY291 | cds-NP_010457.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:794906-796963:+ | gene-YDR172W_MUCL30387 | rna-NM_001180479.3_MUCL30387 | cds-NP_010457.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:783167-785224:+ | gene-YDR172W_MUCL30388 | rna-NM_001180479.3_MUCL30388 | cds-NP_010457.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:768653-770710:+ | gene-YDR172W_MUCL39482 | rna-NM_001180479.3_MUCL39482 | cds-NP_010457.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:707364-709421:+ | gene-YDR172W_MUCL42920 | rna-NM_001180479.3_MUCL42920 | cds-NP_010457.3_MUCL42920 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:808247-810304:+ | gene-YDR172W_NCIM3186 | rna-NM_001180479.3_NCIM3186 | cds-NP_010457.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:771808-773865:+ | gene-YDR172W_NCYC1407 | rna-NM_001180479.3_NCYC1407 | cds-NP_010457.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:788525-790582:+ | gene-YDR172W_PE2H3 | rna-NM_001180479.3_PE2H3 | cds-NP_010457.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:787830-789887:+ | gene-YDR172W_PE2H4 | rna-NM_001180479.3_PE2H4 | cds-NP_010457.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:808324-810381:+ | gene-YDR172W_S288C | rna-NM_001180479.3_S288C | cds-NP_010457.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:154036-156093:+ | gene-YDR172W_SA1 | rna-NM_001180479.3_SA1 | cds-NP_010457.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:783960-786017:+ | gene-YDR172W_ThermosaccDry | rna-NM_001180479.3_ThermosaccDry | cds-NP_010457.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:799222-801279:+ | gene-YDR172W_VR1 | rna-NM_001180479.3_VR1 | cds-NP_010457.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:46693-48750:+ | gene-YDR172W_ZTW1 | rna-NM_001180479.3_ZTW1 | cds-NP_010457.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:789117-791174:+ | gene-YDR172W_Sparadoxus | rna-NM_001180479.3_Sparadoxus | cds-NP_010457.3_Sparadoxus | 92.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |