Gene name: STE5
Reference locus (S288C): YDR103W
Gene biotype: protein_coding
Description: Protein STE5; Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation
Top 10 interactors (score): STE4 (0.999); STE11 (0.999); FUS3 (0.999); STE7 (0.999); STE18 (0.996); KSS1 (0.991); STE20 (0.989); BEM1 (0.969); GPA1 (0.963); STE2 (0.959); FAR1 (0.952); STE50 (0.949); STE12 (0.943); CDC24 (0.929); FUS1 (0.914); PTC1 (0.899); SST2 (0.865); MSG5 (0.862); CDC42 (0.84); CDC28 (0.819)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:629630-632383:+ | gene-YDR103W_AKU4011 | rna-NM_001180411.1_AKU4011 | cds-NP_010388.1_AKU4011 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:492532-495285:- | gene-YDR103W_BG1 | rna-NM_001180411.1_BG1 | cds-NP_010388.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:661717-664470:+ | gene-YDR103W_Bruggeman | rna-NM_001180411.1_Bruggeman | cds-NP_010388.1_Bruggeman | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:647591-650344:+ | gene-YDR103W_CAT1 | rna-NM_001180411.1_CAT1 | cds-NP_010388.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:620649-623402:+ | gene-YDR103W_CBS1585 | rna-NM_001180411.1_CBS1585 | cds-NP_010388.1_CBS1585 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:646050-648803:+ | gene-YDR103W_CBS436 | rna-NM_001180411.1_CBS436 | cds-NP_010388.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:617064-619817:+ | gene-YDR103W_CBS6412 | rna-NM_001180411.1_CBS6412 | cds-NP_010388.1_CBS6412 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:645595-648348:+ | gene-YDR103W_CBS6413 | rna-NM_001180411.1_CBS6413 | cds-NP_010388.1_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:651111-653864:+ | gene-YDR103W_CENPK1137D | rna-NM_001180411.1_CENPK1137D | cds-NP_010388.1_CENPK1137D | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:631413-634166:+ | gene-YDR103W_EthanolRed | rna-NM_001180411.1_EthanolRed | cds-NP_010388.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:638207-640960:+ | gene-YDR103W_FaliES1 | rna-NM_001180411.1_FaliES1 | cds-NP_010388.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000125.1:6876-9629:+ | gene-YDR103W_JAY291 | rna-NM_001180411.1_JAY291 | cds-NP_010388.1_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:647625-650378:+ | gene-YDR103W_MUCL30387 | rna-NM_001180411.1_MUCL30387 | cds-NP_010388.1_MUCL30387 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:636647-639400:+ | gene-YDR103W_MUCL30388 | rna-NM_001180411.1_MUCL30388 | cds-NP_010388.1_MUCL30388 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:622019-624772:+ | gene-YDR103W_MUCL39482 | rna-NM_001180411.1_MUCL39482 | cds-NP_010388.1_MUCL39482 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:559965-562718:+ | gene-YDR103W_MUCL42920 | rna-NM_001180411.1_MUCL42920 | cds-NP_010388.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:658273-661026:+ | gene-YDR103W_NCIM3186 | rna-NM_001180411.1_NCIM3186 | cds-NP_010388.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:620930-623683:+ | gene-YDR103W_NCYC1407 | rna-NM_001180411.1_NCYC1407 | cds-NP_010388.1_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:640743-643496:+ | gene-YDR103W_PE2H3 | rna-NM_001180411.1_PE2H3 | cds-NP_010388.1_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:640048-642801:+ | gene-YDR103W_PE2H4 | rna-NM_001180411.1_PE2H4 | cds-NP_010388.1_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:658350-661103:+ | gene-YDR103W_S288C | rna-NM_001180411.1_S288C | cds-NP_010388.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:6957-9710:+ | gene-YDR103W_SA1 | rna-NM_001180411.1_SA1 | cds-NP_010388.1_SA1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:637736-640489:+ | gene-YDR103W_ThermosaccDry | rna-NM_001180411.1_ThermosaccDry | cds-NP_010388.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:650656-653409:+ | gene-YDR103W_VR1 | rna-NM_001180411.1_VR1 | cds-NP_010388.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:635321-638074:+ | gene-YDR103W_ZTW1 | rna-NM_001180411.1_ZTW1 | cds-NP_010388.1_ZTW1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:640005-642752:+ | gene-YDR103W_Sparadoxus | rna-NM_001180411.1_Sparadoxus | cds-NP_010388.1_Sparadoxus | 86.0 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |