Gene name: STE24
Reference locus (S288C): YJR117W
Gene biotype: protein_coding
Description: CAAX prenyl protease 1; Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant
Top 10 interactors (score): RCE1 (0.999); STE14 (0.999); RAM2 (0.998); RAM1 (0.995); STE23 (0.972); AXL1 (0.956); ERV29 (0.886); CDC43 (0.885); MF(ALPHA)1 (0.874); SCJ1 (0.86); STE6 (0.846); WBP1 (0.784); SEC66 (0.755); MFA1 (0.749); SEC61 (0.741); ATP2 (0.735); RAS2 (0.713); CNE1 (0.708); SEC72 (0.705); YJL068C (0.695)
Homologues (species, bitscore): ZMPSTE24 (Homo sapiens, 261.5); Zmpste24 (Mus musculus, 262.3); zmpste24 (Danio rerio, 258.1); zmpste24 (Xenopus tropicalis, 259.2); ste24a (Drosophila melanogaster, 273.9); fce-1 (Caenorhabditis elegans, 223.8); ATSTE24 (Arabidopsis thaliana, 326.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:613499-614860:+ | gene-YJR117W_AKU4011 | rna-NM_001181775.1_AKU4011 | cds-NP_012651.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000076.1:58714-60075:- | gene-YJR117W_BG1 | rna-NM_001181775.1_BG1 | cds-NP_012651.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:629211-630572:+ | gene-YJR117W_Bruggeman | rna-NM_001181775.1_Bruggeman | cds-NP_012651.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:632983-634344:+ | gene-YJR117W_CAT1 | rna-NM_001181775.1_CAT1 | cds-NP_012651.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:625541-626902:+ | gene-YJR117W_CBS1585 | rna-NM_001181775.1_CBS1585 | cds-NP_012651.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:644418-645779:+ | gene-YJR117W_CBS436 | rna-NM_001181775.1_CBS436 | cds-NP_012651.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:612317-613678:+ | gene-YJR117W_CBS6412 | rna-NM_001181775.1_CBS6412 | cds-NP_012651.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:614972-616333:+ | gene-YJR117W_CBS6413 | rna-NM_001181775.1_CBS6413 | cds-NP_012651.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:624365-625726:+ | gene-YJR117W_CENPK1137D | rna-NM_001181775.1_CENPK1137D | cds-NP_012651.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:617914-619275:+ | gene-YJR117W_EthanolRed | rna-NM_001181775.1_EthanolRed | cds-NP_012651.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:629377-630738:+ | gene-YJR117W_FaliES1 | rna-NM_001181775.1_FaliES1 | cds-NP_012651.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:58384-59745:- | gene-YJR117W_JAY291 | rna-NM_001181775.1_JAY291 | cds-NP_012651.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:628004-629365:+ | gene-YJR117W_MUCL30387 | rna-NM_001181775.1_MUCL30387 | cds-NP_012651.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:625729-627090:+ | gene-YJR117W_MUCL30388 | rna-NM_001181775.1_MUCL30388 | cds-NP_012651.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:619024-620385:+ | gene-YJR117W_MUCL39482 | rna-NM_001181775.1_MUCL39482 | cds-NP_012651.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:623513-624874:+ | gene-YJR117W_MUCL42920 | rna-NM_001181775.1_MUCL42920 | cds-NP_012651.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:641986-643347:+ | gene-YJR117W_NCIM3186 | rna-NM_001181775.1_NCIM3186 | cds-NP_012651.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:616574-617935:+ | gene-YJR117W_NCYC1407 | rna-NM_001181775.1_NCYC1407 | cds-NP_012651.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:634773-636134:+ | gene-YJR117W_PE2H3 | rna-NM_001181775.1_PE2H3 | cds-NP_012651.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:628462-629823:+ | gene-YJR117W_PE2H4 | rna-NM_001181775.1_PE2H4 | cds-NP_012651.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:642007-643368:+ | gene-YJR117W_S288C | rna-NM_001181775.1_S288C | cds-NP_012651.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000069.1:58759-60120:- | gene-YJR117W_SA1 | rna-NM_001181775.1_SA1 | cds-NP_012651.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:623308-624669:+ | gene-YJR117W_ThermosaccDry | rna-NM_001181775.1_ThermosaccDry | cds-NP_012651.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:625696-627057:+ | gene-YJR117W_VR1 | rna-NM_001181775.1_VR1 | cds-NP_012651.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:602660-604021:+ | gene-YJR117W_ZTW1 | rna-NM_001181775.1_ZTW1 | cds-NP_012651.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:636923-638284:+ | gene-YJR117W_Sparadoxus | rna-NM_001181775.1_Sparadoxus | cds-NP_012651.1_Sparadoxus | 92.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |