Gene name: STE14
Reference locus (S288C): YDR410C
Gene biotype: protein_coding
Description: Protein-S-isoprenylcysteine O-methyltransferase; Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family
Top 10 interactors (score): RCE1 (0.999); STE24 (0.999); RAM2 (0.99); RAM1 (0.955); STE6 (0.945); RAS2 (0.94); MF(ALPHA)1 (0.916); AXL1 (0.911); STE23 (0.902); CDC43 (0.898); RAS1 (0.827); STE2 (0.821); KEX1 (0.759); STE13 (0.749); STE3 (0.748); MFA1 (0.744); RPL10 (0.709); KEX2 (0.66); SHR5 (0.658); GPA1 (0.626)
Homologues (species, bitscore): ICMT (Homo sapiens, 181.4); Icmt (Mus musculus, 185.7); icmt (Danio rerio, 175.3); icmt (Xenopus tropicalis, 181.0); ste14 (Drosophila melanogaster, 168.3); F21F3.3 (Caenorhabditis elegans, 154.5); ATSTE14B (Arabidopsis thaliana, 142.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1232525-1233244:- | gene-YDR410C_AKU4011 | rna-NM_001180718.1_AKU4011 | cds-NP_010698.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:111008-111727:- | gene-YDR410C_BG1 | rna-NM_001180718.1_BG1 | cds-NP_010698.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1263406-1264125:- | gene-YDR410C_Bruggeman | rna-NM_001180718.1_Bruggeman | cds-NP_010698.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1241966-1242685:- | gene-YDR410C_CAT1 | rna-NM_001180718.1_CAT1 | cds-NP_010698.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1227445-1228164:- | gene-YDR410C_CBS1585 | rna-NM_001180718.1_CBS1585 | cds-NP_010698.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1246304-1247023:- | gene-YDR410C_CBS436 | rna-NM_001180718.1_CBS436 | cds-NP_010698.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1223499-1224218:- | gene-YDR410C_CBS6412 | rna-NM_001180718.1_CBS6412 | cds-NP_010698.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1245354-1246073:- | gene-YDR410C_CBS6413 | rna-NM_001180718.1_CBS6413 | cds-NP_010698.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1291031-1291750:- | gene-YDR410C_CENPK1137D | rna-NM_001180718.1_CENPK1137D | cds-NP_010698.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1236930-1237649:- | gene-YDR410C_EthanolRed | rna-NM_001180718.1_EthanolRed | cds-NP_010698.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1240237-1240956:- | gene-YDR410C_FaliES1 | rna-NM_001180718.1_FaliES1 | cds-NP_010698.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000181.1:14574-15293:+ | gene-YDR410C_JAY291 | rna-NM_001180718.1_JAY291 | cds-NP_010698.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1246968-1247687:- | gene-YDR410C_MUCL30387 | rna-NM_001180718.1_MUCL30387 | cds-NP_010698.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1229074-1229793:- | gene-YDR410C_MUCL30388 | rna-NM_001180718.1_MUCL30388 | cds-NP_010698.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1218773-1219492:- | gene-YDR410C_MUCL39482 | rna-NM_001180718.1_MUCL39482 | cds-NP_010698.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1161204-1161923:- | gene-YDR410C_MUCL42920 | rna-NM_001180718.1_MUCL42920 | cds-NP_010698.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1292295-1293014:- | gene-YDR410C_NCIM3186 | rna-NM_001180718.1_NCIM3186 | cds-NP_010698.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1232745-1233464:- | gene-YDR410C_NCYC1407 | rna-NM_001180718.1_NCYC1407 | cds-NP_010698.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1242877-1243596:- | gene-YDR410C_PE2H3 | rna-NM_001180718.1_PE2H3 | cds-NP_010698.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1248445-1249164:- | gene-YDR410C_PE2H4 | rna-NM_001180718.1_PE2H4 | cds-NP_010698.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1292372-1293091:- | gene-YDR410C_S288C | rna-NM_001180718.1_S288C | cds-NP_010698.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000071.1:14696-15415:+ | gene-YDR410C_SA1 | rna-NM_001180718.1_SA1 | cds-NP_010698.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1244499-1245218:- | gene-YDR410C_ThermosaccDry | rna-NM_001180718.1_ThermosaccDry | cds-NP_010698.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1259684-1260403:- | gene-YDR410C_VR1 | rna-NM_001180718.1_VR1 | cds-NP_010698.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:287294-288013:- | gene-YDR410C_ZTW1 | rna-NM_001180718.1_ZTW1 | cds-NP_010698.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1239710-1240431:- | gene-YDR410C_Sparadoxus | rna-NM_001180718.1_Sparadoxus | cds-NP_010698.1_Sparadoxus | 87.3 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |