Gene name: SSM4
Reference locus (S288C): YIL030C
Gene biotype: protein_coding
Description: ERAD-associated E3 ubiquitin-protein ligase DOA10; Membrane-embedded ubiquitin-protein ligase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and a transmembrane domain containing substrate (ERAD-M), Sbh2p; C-terminal element (CTE), conserved in human ortholog MARCH10/TEB4, determines substrate selectivity
Top 10 interactors (score): UBC7 (0.999); CDC48 (0.999); HRD1 (0.999); NPL4 (0.999); CUE1 (0.999); UBX2 (0.999); UFD1 (0.997); HRD3 (0.996); DER1 (0.993); UBC6 (0.99); UBR1 (0.988); USA1 (0.985); SAN1 (0.969); YOS9 (0.955); SEC61 (0.926); YIL029C (0.918); FPR3 (0.918); DEG1 (0.915); UFD2 (0.897); UBC4 (0.887)
Homologues (species, bitscore): MARCH6 (Homo sapiens, 82.4); March6 (Mus musculus, 82.8); march6 (Danio rerio, 87.8); march6 (Xenopus tropicalis, 79.3); CG1317 (Drosophila melanogaster, 90.5); marc-6 (Caenorhabditis elegans, 98.6); CER9 (Arabidopsis thaliana, 115.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:292887-296846:- | gene-YIL030C_AKU4011 | rna-NM_001179380.3_AKU4011 | cds-NP_012234.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000164.1:154330-158289:- | gene-YIL030C_BG1 | rna-NM_001179380.3_BG1 | cds-NP_012234.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:299149-303108:- | gene-YIL030C_Bruggeman | rna-NM_001179380.3_Bruggeman | cds-NP_012234.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:287065-291024:- | gene-YIL030C_CAT1 | rna-NM_001179380.3_CAT1 | cds-NP_012234.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:292727-296686:- | gene-YIL030C_CBS1585 | rna-NM_001179380.3_CBS1585 | cds-NP_012234.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:288028-291987:- | gene-YIL030C_CBS436 | rna-NM_001179380.3_CBS436 | cds-NP_012234.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:289342-293301:- | gene-YIL030C_CBS6412 | rna-NM_001179380.3_CBS6412 | cds-NP_012234.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:284890-288849:- | gene-YIL030C_CBS6413 | rna-NM_001179380.3_CBS6413 | cds-NP_012234.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:287959-291918:- | gene-YIL030C_CENPK1137D | rna-NM_001179380.3_CENPK1137D | cds-NP_012234.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:276813-280772:- | gene-YIL030C_EthanolRed | rna-NM_001179380.3_EthanolRed | cds-NP_012234.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:294352-298311:- | gene-YIL030C_FaliES1 | rna-NM_001179380.3_FaliES1 | cds-NP_012234.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000365.1:578-4537:+ | gene-YIL030C_JAY291 | rna-NM_001179380.3_JAY291 | cds-NP_012234.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:295999-299958:- | gene-YIL030C_MUCL30387 | rna-NM_001179380.3_MUCL30387 | cds-NP_012234.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:292602-296561:- | gene-YIL030C_MUCL30388 | rna-NM_001179380.3_MUCL30388 | cds-NP_012234.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:293567-297526:- | gene-YIL030C_MUCL39482 | rna-NM_001179380.3_MUCL39482 | cds-NP_012234.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:296689-300648:- | gene-YIL030C_MUCL42920 | rna-NM_001179380.3_MUCL42920 | cds-NP_012234.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:296050-300009:- | gene-YIL030C_NCIM3186 | rna-NM_001179380.3_NCIM3186 | cds-NP_012234.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:297840-301799:- | gene-YIL030C_NCYC1407 | rna-NM_001179380.3_NCYC1407 | cds-NP_012234.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:291099-295058:- | gene-YIL030C_PE2H3 | rna-NM_001179380.3_PE2H3 | cds-NP_012234.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:285805-289764:- | gene-YIL030C_PE2H4 | rna-NM_001179380.3_PE2H4 | cds-NP_012234.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:296050-300009:- | gene-YIL030C_S288C | rna-NM_001179380.3_S288C | cds-NP_012234.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000031.1:26149-30108:+ | gene-YIL030C_SA1 | rna-NM_001179380.3_SA1 | cds-NP_012234.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:293021-296980:- | gene-YIL030C_ThermosaccDry | rna-NM_001179380.3_ThermosaccDry | cds-NP_012234.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:290687-294646:- | gene-YIL030C_VR1 | rna-NM_001179380.3_VR1 | cds-NP_012234.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:266851-270810:- | gene-YIL030C_ZTW1 | rna-NM_001179380.3_ZTW1 | cds-NP_012234.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:288915-292883:- | gene-YIL030C_Sparadoxus | rna-NM_001179380.3_Sparadoxus | cds-NP_012234.3_Sparadoxus | 90.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |