Gene name: SSL2
Reference locus (S288C): YIL143C
Gene biotype: protein_coding
Description: Tfiih/ner complex atpase/helicase subunit ssl2; DNA repair helicase RAD25; Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3; Belongs to the helicase family. RAD25/XPB s [...]
Top 10 interactors (score): TFA2 (0.999); TFB6 (0.999); SPT15 (0.999); TFG2 (0.999); SSL1 (0.999); KIN28 (0.999); TFB3 (0.999); TFB4 (0.999); TFA1 (0.999); SUA7 (0.999); TFB1 (0.999); RAD3 (0.999); TFB5 (0.999); TFB2 (0.999); RPO21 (0.999); RAD1 (0.999); CCL1 (0.999); RPB11 (0.998); RAD2 (0.998); RPB5 (0.998)
Homologues (species, bitscore): ERCC3 (Homo sapiens, 827.4); Ercc3 (Mus musculus, 827.8); ercc3 (Danio rerio, 798.1); ercc3 (Xenopus tropicalis, 826.6); hay (Drosophila melanogaster, 827.4); Y66D12A.15 (Caenorhabditis elegans, 795.4); XPB1 (Arabidopsis thaliana, 778.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:81729-84260:- | gene-YIL143C_AKU4011 | rna-NM_001179491.1_AKU4011 | cds-NP_012123.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000174.1:53103-55634:+ | gene-YIL143C_BG1 | rna-NM_001179491.1_BG1 | cds-NP_012123.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:84486-87017:- | gene-YIL143C_Bruggeman | rna-NM_001179491.1_Bruggeman | cds-NP_012123.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:78298-80829:- | gene-YIL143C_CAT1 | rna-NM_001179491.1_CAT1 | cds-NP_012123.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:81932-84463:- | gene-YIL143C_CBS1585 | rna-NM_001179491.1_CBS1585 | cds-NP_012123.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:73072-75603:- | gene-YIL143C_CBS436 | rna-NM_001179491.1_CBS436 | cds-NP_012123.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:79462-81993:- | gene-YIL143C_CBS6412 | rna-NM_001179491.1_CBS6412 | cds-NP_012123.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:73617-76148:- | gene-YIL143C_CBS6413 | rna-NM_001179491.1_CBS6413 | cds-NP_012123.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:72212-74743:- | gene-YIL143C_CENPK1137D | rna-NM_001179491.1_CENPK1137D | cds-NP_012123.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:67265-69796:- | gene-YIL143C_EthanolRed | rna-NM_001179491.1_EthanolRed | cds-NP_012123.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:83068-85599:- | gene-YIL143C_FaliES1 | rna-NM_001179491.1_FaliES1 | cds-NP_012123.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000319.1:22756-25287:+ | gene-YIL143C_JAY291 | rna-NM_001179491.1_JAY291 | cds-NP_012123.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:82247-84778:- | gene-YIL143C_MUCL30387 | rna-NM_001179491.1_MUCL30387 | cds-NP_012123.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:81495-83986:- | gene-YIL143C_MUCL30388 | rna-NM_001179491.1_MUCL30388 | cds-NP_012123.1_MUCL30388 | 95.9 | 98.1 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:82858-85389:- | gene-YIL143C_MUCL39482 | rna-NM_001179491.1_MUCL39482 | cds-NP_012123.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:86059-88590:- | gene-YIL143C_MUCL42920 | rna-NM_001179491.1_MUCL42920 | cds-NP_012123.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:80510-83041:- | gene-YIL143C_NCIM3186 | rna-NM_001179491.1_NCIM3186 | cds-NP_012123.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:86823-89354:- | gene-YIL143C_NCYC1407 | rna-NM_001179491.1_NCYC1407 | cds-NP_012123.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:81445-83976:- | gene-YIL143C_PE2H3 | rna-NM_001179491.1_PE2H3 | cds-NP_012123.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:75407-77938:- | gene-YIL143C_PE2H4 | rna-NM_001179491.1_PE2H4 | cds-NP_012123.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:80510-83041:- | gene-YIL143C_S288C | rna-NM_001179491.1_S288C | cds-NP_012123.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000050.1:59085-61616:- | gene-YIL143C_SA1 | rna-NM_001179491.1_SA1 | cds-NP_012123.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:81678-84209:- | gene-YIL143C_ThermosaccDry | rna-NM_001179491.1_ThermosaccDry | cds-NP_012123.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:78835-81366:- | gene-YIL143C_VR1 | rna-NM_001179491.1_VR1 | cds-NP_012123.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:56659-59190:- | gene-YIL143C_ZTW1 | rna-NM_001179491.1_ZTW1 | cds-NP_012123.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:74450-76981:- | gene-YIL143C_Sparadoxus | rna-NM_001179491.1_Sparadoxus | cds-NP_012123.1_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |