Gene name: SSK2
Reference locus (S288C): YNR031C
Gene biotype: protein_coding
Description: MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication
Top 10 interactors (score): PBS2 (0.999); SSK1 (0.999); YPD1 (0.988); SLN1 (0.983); SHO1 (0.977); SSK22 (0.951); STE50 (0.889); PTP3 (0.866); SKN7 (0.865); OPY2 (0.855); PTP2 (0.852); PTC1 (0.845); SKO1 (0.842); CDC42 (0.833); MSB2 (0.819); ACT1 (0.807); HOG1 (0.807); STE20 (0.795); HOT1 (0.792); FPS1 (0.791)
Homologues (species, bitscore): MAP3K4 (Homo sapiens, 218.8); Mekk4 (Mus musculus, 221.5); map3k4 (Danio rerio, 223.0); Map3k3 (Xenopus tropicalis, 164.9); Mekk1 (Drosophila melanogaster, 218.4); nsy-1 (Caenorhabditis elegans, 164.5); NP3 (Arabidopsis thaliana, 206.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:664339-669078:- | gene-YNR031C_AKU4011 | rna-NM_001183208.1_AKU4011 | cds-NP_014428.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:572204-576943:- | gene-YNR031C_BG1 | rna-NM_001183208.1_BG1 | cds-NP_014428.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:681792-686531:- | gene-YNR031C_Bruggeman | rna-NM_001183208.1_Bruggeman | cds-NP_014428.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:716049-720788:- | gene-YNR031C_CAT1 | rna-NM_001183208.1_CAT1 | cds-NP_014428.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:670094-674833:- | gene-YNR031C_CBS1585 | rna-NM_001183208.1_CBS1585 | cds-NP_014428.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:731763-736502:- | gene-YNR031C_CBS436 | rna-NM_001183208.1_CBS436 | cds-NP_014428.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:659282-664021:- | gene-YNR031C_CBS6412 | rna-NM_001183208.1_CBS6412 | cds-NP_014428.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:660987-665726:- | gene-YNR031C_CBS6413 | rna-NM_001183208.1_CBS6413 | cds-NP_014428.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:674441-679180:- | gene-YNR031C_CENPK1137D | rna-NM_001183208.1_CENPK1137D | cds-NP_014428.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:666031-670770:- | gene-YNR031C_EthanolRed | rna-NM_001183208.1_EthanolRed | cds-NP_014428.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:657234-661973:- | gene-YNR031C_FaliES1 | rna-NM_001183208.1_FaliES1 | cds-NP_014428.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000037.1:40807-45546:+ | gene-YNR031C_JAY291 | rna-NM_001183208.1_JAY291 | cds-NP_014428.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:679549-684288:- | gene-YNR031C_MUCL30387 | rna-NM_001183208.1_MUCL30387 | cds-NP_014428.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:720372-725111:- | gene-YNR031C_MUCL30388 | rna-NM_001183208.1_MUCL30388 | cds-NP_014428.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:661594-666333:- | gene-YNR031C_MUCL39482 | rna-NM_001183208.1_MUCL39482 | cds-NP_014428.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:665767-670506:- | gene-YNR031C_MUCL42920 | rna-NM_001183208.1_MUCL42920 | cds-NP_014428.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:680663-685402:- | gene-YNR031C_NCIM3186 | rna-NM_001183208.1_NCIM3186 | cds-NP_014428.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:664102-668841:- | gene-YNR031C_NCYC1407 | rna-NM_001183208.1_NCYC1407 | cds-NP_014428.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:665194-669933:- | gene-YNR031C_PE2H3 | rna-NM_001183208.1_PE2H3 | cds-NP_014428.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:666512-671251:- | gene-YNR031C_PE2H4 | rna-NM_001183208.1_PE2H4 | cds-NP_014428.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:680694-685433:- | gene-YNR031C_S288C | rna-NM_001183208.1_S288C | cds-NP_014428.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000074.1:40957-45696:+ | gene-YNR031C_SA1 | rna-NM_001183208.1_SA1 | cds-NP_014428.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:657571-662310:- | gene-YNR031C_ThermosaccDry | rna-NM_001183208.1_ThermosaccDry | cds-NP_014428.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:699569-704308:- | gene-YNR031C_VR1 | rna-NM_001183208.1_VR1 | cds-NP_014428.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:566980-571719:- | gene-YNR031C_ZTW1 | rna-NM_001183208.1_ZTW1 | cds-NP_014428.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:671673-676411:- | gene-YNR031C_Sparadoxus | rna-NM_001183208.1_Sparadoxus | cds-NP_014428.1_Sparadoxus | 91.6 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |