Gene name: SRV2
Reference locus (S288C): YNL138W
Gene biotype: protein_coding
Description: CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog
Top 10 interactors (score): CYR1 (0.999); ACT1 (0.999); COF1 (0.999); ABP1 (0.99); TWF1 (0.986); PFY1 (0.982); AIP1 (0.97); SAC6 (0.969); BCY1 (0.932); CMP2 (0.897); DDI1 (0.896); MAM3 (0.895); PAH1 (0.893); CNA1 (0.889); RAS2 (0.839); CRN1 (0.818); SLA2 (0.817); RVS167 (0.815); ARK1 (0.809); PRK1 (0.8)
Homologues (species, bitscore): CAP1 (Homo sapiens, 281.6); Cap1 (Mus musculus, 283.5); cap2 (Danio rerio, 283.9); cap1 (Xenopus tropicalis, 269.6); capt (Drosophila melanogaster, 269.6); cas-1 (Caenorhabditis elegans, 264.2); CAP1 (Arabidopsis thaliana, 221.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:360426-362006:+ | gene-YNL138W_AKU4011 | rna-NM_001182976.1_AKU4011 | cds-NP_014261.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:264418-265998:+ | gene-YNL138W_BG1 | rna-NM_001182976.1_BG1 | cds-NP_014261.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:370523-372103:+ | gene-YNL138W_Bruggeman | rna-NM_001182976.1_Bruggeman | cds-NP_014261.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:413719-415299:+ | gene-YNL138W_CAT1 | rna-NM_001182976.1_CAT1 | cds-NP_014261.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:361045-362625:+ | gene-YNL138W_CBS1585 | rna-NM_001182976.1_CBS1585 | cds-NP_014261.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:429440-431020:+ | gene-YNL138W_CBS436 | rna-NM_001182976.1_CBS436 | cds-NP_014261.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:356499-358079:+ | gene-YNL138W_CBS6412 | rna-NM_001182976.1_CBS6412 | cds-NP_014261.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:357463-359043:+ | gene-YNL138W_CBS6413 | rna-NM_001182976.1_CBS6413 | cds-NP_014261.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:360593-362173:+ | gene-YNL138W_CENPK1137D | rna-NM_001182976.1_CENPK1137D | cds-NP_014261.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:357417-358997:+ | gene-YNL138W_EthanolRed | rna-NM_001182976.1_EthanolRed | cds-NP_014261.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:353319-354899:+ | gene-YNL138W_FaliES1 | rna-NM_001182976.1_FaliES1 | cds-NP_014261.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000021.1:9699-11279:+ | gene-YNL138W_JAY291 | rna-NM_001182976.1_JAY291 | cds-NP_014261.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:366538-368118:+ | gene-YNL138W_MUCL30387 | rna-NM_001182976.1_MUCL30387 | cds-NP_014261.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:401655-403235:+ | gene-YNL138W_MUCL30388 | rna-NM_001182976.1_MUCL30388 | cds-NP_014261.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:358325-359905:+ | gene-YNL138W_MUCL39482 | rna-NM_001182976.1_MUCL39482 | cds-NP_014261.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:361320-362900:+ | gene-YNL138W_MUCL42920 | rna-NM_001182976.1_MUCL42920 | cds-NP_014261.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:366710-368290:+ | gene-YNL138W_NCIM3186 | rna-NM_001182976.1_NCIM3186 | cds-NP_014261.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:360457-362037:+ | gene-YNL138W_NCYC1407 | rna-NM_001182976.1_NCYC1407 | cds-NP_014261.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:357456-359036:+ | gene-YNL138W_PE2H3 | rna-NM_001182976.1_PE2H3 | cds-NP_014261.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:356844-358424:+ | gene-YNL138W_PE2H4 | rna-NM_001182976.1_PE2H4 | cds-NP_014261.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:366741-368321:+ | gene-YNL138W_S288C | rna-NM_001182976.1_S288C | cds-NP_014261.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000018.1:45192-46772:- | gene-YNL138W_SA1 | rna-NM_001182976.1_SA1 | cds-NP_014261.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:354173-355753:+ | gene-YNL138W_ThermosaccDry | rna-NM_001182976.1_ThermosaccDry | cds-NP_014261.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:372836-374416:+ | gene-YNL138W_VR1 | rna-NM_001182976.1_VR1 | cds-NP_014261.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:264007-265587:+ | gene-YNL138W_ZTW1 | rna-NM_001182976.1_ZTW1 | cds-NP_014261.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:364980-366560:+ | gene-YNL138W_Sparadoxus | rna-NM_001182976.1_Sparadoxus | cds-NP_014261.1_Sparadoxus | 89.3 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |