SRV2 (YNL138W)


Gene profile

Gene name: SRV2
Reference locus (S288C): YNL138W
Gene biotype: protein_coding

Description: CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog

Top 10 interactors (score): CYR1 (0.999); ACT1 (0.999); COF1 (0.999); ABP1 (0.99); TWF1 (0.986); PFY1 (0.982); AIP1 (0.97); SAC6 (0.969); BCY1 (0.932); CMP2 (0.897); DDI1 (0.896); MAM3 (0.895); PAH1 (0.893); CNA1 (0.889); RAS2 (0.839); CRN1 (0.818); SLA2 (0.817); RVS167 (0.815); ARK1 (0.809); PRK1 (0.8)

Homologues (species, bitscore): CAP1 (Homo sapiens, 281.6); Cap1 (Mus musculus, 283.5); cap2 (Danio rerio, 283.9); cap1 (Xenopus tropicalis, 269.6); capt (Drosophila melanogaster, 269.6); cas-1 (Caenorhabditis elegans, 264.2); CAP1 (Arabidopsis thaliana, 221.1)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005308.1:360426-362006:+ gene-YNL138W_AKU4011 rna-NM_001182976.1_AKU4011 cds-NP_014261.1_AKU4011 99.6 100.0 Verified 1 1 1 False True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000155.1:264418-265998:+ gene-YNL138W_BG1 rna-NM_001182976.1_BG1 cds-NP_014261.1_BG1 99.6 100.0 Verified 1 1 1 False True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005516.1:370523-372103:+ gene-YNL138W_Bruggeman rna-NM_001182976.1_Bruggeman cds-NP_014261.1_Bruggeman 99.6 100.0 Verified 1 1 1 False True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005532.1:413719-415299:+ gene-YNL138W_CAT1 rna-NM_001182976.1_CAT1 cds-NP_014261.1_CAT1 99.6 100.0 Verified 1 1 1 False True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005372.1:361045-362625:+ gene-YNL138W_CBS1585 rna-NM_001182976.1_CBS1585 cds-NP_014261.1_CBS1585 99.6 100.0 Verified 1 1 1 False True False False False
CBS436 GCA_001738355.1 Sake Asia CM005356.1:429440-431020:+ gene-YNL138W_CBS436 rna-NM_001182976.1_CBS436 cds-NP_014261.1_CBS436 99.6 100.0 Mismatch 1 1 1 False True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005340.1:356499-358079:+ gene-YNL138W_CBS6412 rna-NM_001182976.1_CBS6412 cds-NP_014261.1_CBS6412 99.6 100.0 Mismatch 1 1 1 False True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005324.1:357463-359043:+ gene-YNL138W_CBS6413 rna-NM_001182976.1_CBS6413 cds-NP_014261.1_CBS6413 99.6 100.0 Verified 1 1 1 False True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001535.1:360593-362173:+ gene-YNL138W_CENPK1137D rna-NM_001182976.1_CENPK1137D cds-NP_014261.1_CENPK1137D 100.0 100.0 Verified 1 1 1 True True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005484.1:357417-358997:+ gene-YNL138W_EthanolRed rna-NM_001182976.1_EthanolRed cds-NP_014261.1_EthanolRed 99.6 100.0 Verified 1 1 1 False True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005548.1:353319-354899:+ gene-YNL138W_FaliES1 rna-NM_001182976.1_FaliES1 cds-NP_014261.1_FaliES1 99.6 100.0 Verified 1 1 1 False True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000021.1:9699-11279:+ gene-YNL138W_JAY291 rna-NM_001182976.1_JAY291 cds-NP_014261.1_JAY291 99.6 100.0 Verified 1 1 1 False True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005420.1:366538-368118:+ gene-YNL138W_MUCL30387 rna-NM_001182976.1_MUCL30387 cds-NP_014261.1_MUCL30387 99.5 100.0 Verified 1 1 1 False True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005452.1:401655-403235:+ gene-YNL138W_MUCL30388 rna-NM_001182976.1_MUCL30388 cds-NP_014261.1_MUCL30388 99.4 100.0 Verified 1 1 1 False True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005292.1:358325-359905:+ gene-YNL138W_MUCL39482 rna-NM_001182976.1_MUCL39482 cds-NP_014261.1_MUCL39482 99.6 100.0 Verified 1 1 1 False True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005436.1:361320-362900:+ gene-YNL138W_MUCL42920 rna-NM_001182976.1_MUCL42920 cds-NP_014261.1_MUCL42920 99.6 100.0 Verified 1 1 1 False True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011823.1:366710-368290:+ gene-YNL138W_NCIM3186 rna-NM_001182976.1_NCIM3186 cds-NP_014261.1_NCIM3186 99.6 100.0 Verified 1 1 1 False True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005276.1:360457-362037:+ gene-YNL138W_NCYC1407 rna-NM_001182976.1_NCYC1407 cds-NP_014261.1_NCYC1407 99.6 100.0 Verified 1 1 1 False True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994153.1:357456-359036:+ gene-YNL138W_PE2H3 rna-NM_001182976.1_PE2H3 cds-NP_014261.1_PE2H3 99.6 100.0 Verified 1 1 1 False True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999885.1:356844-358424:+ gene-YNL138W_PE2H4 rna-NM_001182976.1_PE2H4 cds-NP_014261.1_PE2H4 99.6 100.0 Verified 1 1 1 False True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001146.8:366741-368321:+ gene-YNL138W_S288C rna-NM_001182976.1_S288C cds-NP_014261.1_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000018.1:45192-46772:- gene-YNL138W_SA1 rna-NM_001182976.1_SA1 cds-NP_014261.1_SA1 99.6 100.0 Verified 1 1 1 False True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005500.1:354173-355753:+ gene-YNL138W_ThermosaccDry rna-NM_001182976.1_ThermosaccDry cds-NP_014261.1_ThermosaccDry 99.6 100.0 Verified 1 1 1 False True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005468.1:372836-374416:+ gene-YNL138W_VR1 rna-NM_001182976.1_VR1 cds-NP_014261.1_VR1 99.6 100.0 Verified 1 1 1 False True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000030.1:264007-265587:+ gene-YNL138W_ZTW1 rna-NM_001182976.1_ZTW1 cds-NP_014261.1_ZTW1 99.6 100.0 Verified 1 1 1 False True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047500.1:364980-366560:+ gene-YNL138W_Sparadoxus rna-NM_001182976.1_Sparadoxus cds-NP_014261.1_Sparadoxus 89.3 99.8 Verified 1 1 1 False True False False False

Additional files