Gene name: SRP1
Reference locus (S288C): YNL189W
Gene biotype: protein_coding
Description: Importin subunit alpha; Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation
Top 10 interactors (score): NUP1 (0.999); SRM1 (0.999); CSE1 (0.999); KAP95 (0.999); NUP2 (0.999); ULP1 (0.997); PSE1 (0.996); NSP1 (0.993); NTF2 (0.993); KAP123 (0.988); STO1 (0.988); CRM1 (0.986); GSP1 (0.986); RNA1 (0.986); NUP60 (0.983); KAP104 (0.979); SEC4 (0.977); SRC1 (0.97); CBC2 (0.966); YRB1 (0.964)
Homologues (species, bitscore): KPNA6 (Homo sapiens, 533.9); Kpna6 (Mus musculus, 533.9); KPNA6 (Danio rerio, 519.6); kpna6 (Xenopus tropicalis, 535.4); Kap-alpha1 (Drosophila melanogaster, 477.6); ima-3 (Caenorhabditis elegans, 405.2); IMPA-1 (Arabidopsis thaliana, 517.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:278027-279655:+ | gene-YNL189W_AKU4011 | rna-NM_001183027.1_AKU4011 | cds-NP_014210.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:181979-183607:+ | gene-YNL189W_BG1 | rna-NM_001183027.1_BG1 | cds-NP_014210.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:288084-289712:+ | gene-YNL189W_Bruggeman | rna-NM_001183027.1_Bruggeman | cds-NP_014210.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:330330-331958:+ | gene-YNL189W_CAT1 | rna-NM_001183027.1_CAT1 | cds-NP_014210.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:278682-280310:+ | gene-YNL189W_CBS1585 | rna-NM_001183027.1_CBS1585 | cds-NP_014210.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:346968-348596:+ | gene-YNL189W_CBS436 | rna-NM_001183027.1_CBS436 | cds-NP_014210.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:274084-275712:+ | gene-YNL189W_CBS6412 | rna-NM_001183027.1_CBS6412 | cds-NP_014210.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:275115-276743:+ | gene-YNL189W_CBS6413 | rna-NM_001183027.1_CBS6413 | cds-NP_014210.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:278088-279716:+ | gene-YNL189W_CENPK1137D | rna-NM_001183027.1_CENPK1137D | cds-NP_014210.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:275013-276641:+ | gene-YNL189W_EthanolRed | rna-NM_001183027.1_EthanolRed | cds-NP_014210.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:270926-272554:+ | gene-YNL189W_FaliES1 | rna-NM_001183027.1_FaliES1 | cds-NP_014210.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000260.1:46000-47628:- | gene-YNL189W_JAY291 | rna-NM_001183027.1_JAY291 | cds-NP_014210.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:283875-285503:+ | gene-YNL189W_MUCL30387 | rna-NM_001183027.1_MUCL30387 | cds-NP_014210.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:318217-319845:+ | gene-YNL189W_MUCL30388 | rna-NM_001183027.1_MUCL30388 | cds-NP_014210.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:275921-277549:+ | gene-YNL189W_MUCL39482 | rna-NM_001183027.1_MUCL39482 | cds-NP_014210.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:278287-279915:+ | gene-YNL189W_MUCL42920 | rna-NM_001183027.1_MUCL42920 | cds-NP_014210.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:284229-285857:+ | gene-YNL189W_NCIM3186 | rna-NM_001183027.1_NCIM3186 | cds-NP_014210.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:278015-279643:+ | gene-YNL189W_NCYC1407 | rna-NM_001183027.1_NCYC1407 | cds-NP_014210.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:274923-276551:+ | gene-YNL189W_PE2H3 | rna-NM_001183027.1_PE2H3 | cds-NP_014210.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:274311-275939:+ | gene-YNL189W_PE2H4 | rna-NM_001183027.1_PE2H4 | cds-NP_014210.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:284260-285888:+ | gene-YNL189W_S288C | rna-NM_001183027.1_S288C | cds-NP_014210.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000018.1:127712-129340:- | gene-YNL189W_SA1 | rna-NM_001183027.1_SA1 | cds-NP_014210.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:271783-273411:+ | gene-YNL189W_ThermosaccDry | rna-NM_001183027.1_ThermosaccDry | cds-NP_014210.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:290247-291875:+ | gene-YNL189W_VR1 | rna-NM_001183027.1_VR1 | cds-NP_014210.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:181611-183239:+ | gene-YNL189W_ZTW1 | rna-NM_001183027.1_ZTW1 | cds-NP_014210.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:282273-283901:+ | gene-YNL189W_Sparadoxus | rna-NM_001183027.1_Sparadoxus | cds-NP_014210.1_Sparadoxus | 93.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |