Gene name: SRB4
Reference locus (S288C): YER022W
Gene biotype: protein_coding
Description: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
Top 10 interactors (score): GAL11 (0.999); MED6 (0.999); MED11 (0.999); SOH1 (0.999); SRB7 (0.999); MED8 (0.999); CSE2 (0.999); SRB2 (0.999); MED7 (0.999); RPO21 (0.999); MED4 (0.999); NUT2 (0.999); SRB5 (0.999); RGR1 (0.999); SRB6 (0.999); SIN4 (0.998); ROX3 (0.998); PGD1 (0.997); MED2 (0.997); MED1 (0.996)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:192839-194902:+ | gene-YER022W_AKU4011 | rna-NM_001178913.1_AKU4011 | cds-NP_010939.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:231181-233244:- | gene-YER022W_BG1 | rna-NM_001178913.1_BG1 | cds-NP_010939.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:200704-202767:+ | gene-YER022W_Bruggeman | rna-NM_001178913.1_Bruggeman | cds-NP_010939.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:195596-197659:+ | gene-YER022W_CAT1 | rna-NM_001178913.1_CAT1 | cds-NP_010939.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:192762-194825:+ | gene-YER022W_CBS1585 | rna-NM_001178913.1_CBS1585 | cds-NP_010939.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:194353-196416:+ | gene-YER022W_CBS436 | rna-NM_001178913.1_CBS436 | cds-NP_010939.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:193006-195069:+ | gene-YER022W_CBS6412 | rna-NM_001178913.1_CBS6412 | cds-NP_010939.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:197792-199855:+ | gene-YER022W_CBS6413 | rna-NM_001178913.1_CBS6413 | cds-NP_010939.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:196751-198814:+ | gene-YER022W_CENPK1137D | rna-NM_001178913.1_CENPK1137D | cds-NP_010939.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:193470-195533:+ | gene-YER022W_EthanolRed | rna-NM_001178913.1_EthanolRed | cds-NP_010939.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:193735-195798:+ | gene-YER022W_FaliES1 | rna-NM_001178913.1_FaliES1 | cds-NP_010939.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000024.1:60388-62451:+ | gene-YER022W_JAY291 | rna-NM_001178913.1_JAY291 | cds-NP_010939.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:196908-198971:+ | gene-YER022W_MUCL30387 | rna-NM_001178913.1_MUCL30387 | cds-NP_010939.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:193143-195206:+ | gene-YER022W_MUCL30388 | rna-NM_001178913.1_MUCL30388 | cds-NP_010939.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:191806-193869:+ | gene-YER022W_MUCL39482 | rna-NM_001178913.1_MUCL39482 | cds-NP_010939.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:198894-200957:+ | gene-YER022W_MUCL42920 | rna-NM_001178913.1_MUCL42920 | cds-NP_010939.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:198811-200874:+ | gene-YER022W_NCIM3186 | rna-NM_001178913.1_NCIM3186 | cds-NP_010939.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:196877-198940:+ | gene-YER022W_NCYC1407 | rna-NM_001178913.1_NCYC1407 | cds-NP_010939.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:201197-203260:+ | gene-YER022W_PE2H3 | rna-NM_001178913.1_PE2H3 | cds-NP_010939.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:197101-199164:+ | gene-YER022W_PE2H4 | rna-NM_001178913.1_PE2H4 | cds-NP_010939.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:198812-200875:+ | gene-YER022W_S288C | rna-NM_001178913.1_S288C | cds-NP_010939.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:42807-44870:- | gene-YER022W_SA1 | rna-NM_001178913.1_SA1 | cds-NP_010939.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:194506-196569:+ | gene-YER022W_ThermosaccDry | rna-NM_001178913.1_ThermosaccDry | cds-NP_010939.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:193257-195320:+ | gene-YER022W_VR1 | rna-NM_001178913.1_VR1 | cds-NP_010939.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:191717-193780:+ | gene-YER022W_ZTW1 | rna-NM_001178913.1_ZTW1 | cds-NP_010939.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:195430-197493:+ | gene-YER022W_Sparadoxus | rna-NM_001178913.1_Sparadoxus | cds-NP_010939.1_Sparadoxus | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |