Gene name: SPT5
Reference locus (S288C): YML010W
Gene biotype: protein_coding
Description: Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life
Top 10 interactors (score): RPB2 (0.999); RPB4 (0.999); RPB7 (0.999); CTR9 (0.999); RPB5 (0.999); SPT6 (0.999); LEO1 (0.999); SPN1 (0.999); RPO21 (0.999); RPB3 (0.999); SPT4 (0.999); ELF1 (0.999); SPT16 (0.999); RTF1 (0.999); RPO26 (0.999); SGV1 (0.999); CDC73 (0.999); DST1 (0.999); RPB9 (0.998); RPB11 (0.997)
Homologues (species, bitscore): SUPT5H (Homo sapiens, 292.0); Supt5 (Mus musculus, 296.6); supt5h (Danio rerio, 270.0); supt5h (Xenopus tropicalis, 254.2); Spt5 (Drosophila melanogaster, 263.8); spt-5 (Caenorhabditis elegans, 249.6); GTA2 (Arabidopsis thaliana, 240.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:297229-300420:+ | gene-YML010W_AKU4011 | rna-NM_001182366.1_AKU4011 | cds-NP_013703.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:242395-245586:- | gene-YML010W_BG1 | rna-NM_001182366.1_BG1 | cds-NP_013703.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:237209-240403:+ | gene-YML010W_Bruggeman | rna-NM_001182366.1_Bruggeman | cds-NP_013703.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:239719-242910:+ | gene-YML010W_CAT1 | rna-NM_001182366.1_CAT1 | cds-NP_013703.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:230207-233398:+ | gene-YML010W_CBS1585 | rna-NM_001182366.1_CBS1585 | cds-NP_013703.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:235735-238926:+ | gene-YML010W_CBS436 | rna-NM_001182366.1_CBS436 | cds-NP_013703.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:343940-347131:+ | gene-YML010W_CBS6412 | rna-NM_001182366.1_CBS6412 | cds-NP_013703.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:229462-232653:+ | gene-YML010W_CBS6413 | rna-NM_001182366.1_CBS6413 | cds-NP_013703.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:242408-245599:+ | gene-YML010W_CENPK1137D | rna-NM_001182366.1_CENPK1137D | cds-NP_013703.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:230241-233432:+ | gene-YML010W_EthanolRed | rna-NM_001182366.1_EthanolRed | cds-NP_013703.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:233207-236398:+ | gene-YML010W_FaliES1 | rna-NM_001182366.1_FaliES1 | cds-NP_013703.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000033.1:200530-203721:- | gene-YML010W_JAY291 | rna-NM_001182366.1_JAY291 | cds-NP_013703.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:234948-238139:+ | gene-YML010W_MUCL30387 | rna-NM_001182366.1_MUCL30387 | cds-NP_013703.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:239609-242800:+ | gene-YML010W_MUCL30388 | rna-NM_001182366.1_MUCL30388 | cds-NP_013703.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:230487-233678:+ | gene-YML010W_MUCL39482 | rna-NM_001182366.1_MUCL39482 | cds-NP_013703.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:236052-239246:+ | gene-YML010W_MUCL42920 | rna-NM_001182366.1_MUCL42920 | cds-NP_013703.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:247631-250822:+ | gene-YML010W_NCIM3186 | rna-NM_001182366.1_NCIM3186 | cds-NP_013703.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:230422-233613:+ | gene-YML010W_NCYC1407 | rna-NM_001182366.1_NCYC1407 | cds-NP_013703.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:236352-239543:+ | gene-YML010W_PE2H3 | rna-NM_001182366.1_PE2H3 | cds-NP_013703.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:242447-245638:+ | gene-YML010W_PE2H4 | rna-NM_001182366.1_PE2H4 | cds-NP_013703.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:247677-250868:+ | gene-YML010W_S288C | rna-NM_001182366.1_S288C | cds-NP_013703.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000005.1:287417-290608:- | gene-YML010W_SA1 | rna-NM_001182366.1_SA1 | cds-NP_013703.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:230269-233460:+ | gene-YML010W_ThermosaccDry | rna-NM_001182366.1_ThermosaccDry | cds-NP_013703.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:234241-237432:+ | gene-YML010W_VR1 | rna-NM_001182366.1_VR1 | cds-NP_013703.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:209328-212519:+ | gene-YML010W_ZTW1 | rna-NM_001182366.1_ZTW1 | cds-NP_013703.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:240983-244186:+ | gene-YML010W_Sparadoxus | rna-NM_001182366.1_Sparadoxus | cds-NP_013703.1_Sparadoxus | 91.1 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |