Gene name: SPA2
Reference locus (S288C): YLL021W
Gene biotype: protein_coding
Description: Protein SPA2; Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication
Top 10 interactors (score): BNI1 (0.999); PEA2 (0.999); BUD6 (0.999); MSB4 (0.994); MSB3 (0.994); SLT2 (0.985); CDC42 (0.98); MKK1 (0.977); BEM1 (0.938); ACT1 (0.937); BCK1 (0.924); MKK2 (0.916); CLA4 (0.915); MYO2 (0.897); KEL1 (0.875); SEC4 (0.867); RHO1 (0.852); FUS2 (0.849); MLC1 (0.846); BEM2 (0.846)
Homologues (species, bitscore): GIT1 (Homo sapiens, 51.6); Zan (Mus musculus, 52.0); LOC568935 (Danio rerio, 53.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:88354-93100:+ | gene-YLL021W_AKU4011 | rna-NM_001181841.1_AKU4011 | cds-NP_013079.1_AKU4011 | 92.1 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:52054-56535:+ | gene-YLL021W_BG1 | rna-NM_001181841.1_BG1 | cds-NP_013079.1_BG1 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:98359-102921:+ | gene-YLL021W_Bruggeman | rna-NM_001181841.1_Bruggeman | cds-NP_013079.1_Bruggeman | 96.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:98977-103539:+ | gene-YLL021W_CAT1 | rna-NM_001181841.1_CAT1 | cds-NP_013079.1_CAT1 | 96.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:96053-100696:+ | gene-YLL021W_CBS1585 | rna-NM_001181841.1_CBS1585 | cds-NP_013079.1_CBS1585 | 94.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:86502-91064:+ | gene-YLL021W_CBS436 | rna-NM_001181841.1_CBS436 | cds-NP_013079.1_CBS436 | 96.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:94742-99460:+ | gene-YLL021W_CBS6412 | rna-NM_001181841.1_CBS6412 | cds-NP_013079.1_CBS6412 | 92.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:96313-100956:+ | gene-YLL021W_CBS6413 | rna-NM_001181841.1_CBS6413 | cds-NP_013079.1_CBS6413 | 94.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:85970-90370:+ | gene-YLL021W_CENPK1137D | rna-NM_001181841.1_CENPK1137D | cds-NP_013079.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:88493-93136:+ | gene-YLL021W_EthanolRed | rna-NM_001181841.1_EthanolRed | cds-NP_013079.1_EthanolRed | 94.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:88064-92707:+ | gene-YLL021W_FaliES1 | rna-NM_001181841.1_FaliES1 | cds-NP_013079.1_FaliES1 | 94.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000083.1:62654-67216:- | gene-YLL021W_JAY291 | rna-NM_001181841.1_JAY291 | cds-NP_013079.1_JAY291 | 96.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:96271-100833:+ | gene-YLL021W_MUCL30387 | rna-NM_001181841.1_MUCL30387 | cds-NP_013079.1_MUCL30387 | 96.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:100501-105063:+ | gene-YLL021W_MUCL30388 | rna-NM_001181841.1_MUCL30388 | cds-NP_013079.1_MUCL30388 | 95.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:96511-101166:+ | gene-YLL021W_MUCL39482 | rna-NM_001181841.1_MUCL39482 | cds-NP_013079.1_MUCL39482 | 93.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:96109-100833:+ | gene-YLL021W_MUCL42920 | rna-NM_001181841.1_MUCL42920 | cds-NP_013079.1_MUCL42920 | 92.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:100921-105321:+ | gene-YLL021W_NCIM3186 | rna-NM_001181841.1_NCIM3186 | cds-NP_013079.1_NCIM3186 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:88130-92773:+ | gene-YLL021W_NCYC1407 | rna-NM_001181841.1_NCYC1407 | cds-NP_013079.1_NCYC1407 | 94.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:94566-99128:+ | gene-YLL021W_PE2H3 | rna-NM_001181841.1_PE2H3 | cds-NP_013079.1_PE2H3 | 96.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:94375-98856:+ | gene-YLL021W_PE2H4 | rna-NM_001181841.1_PE2H4 | cds-NP_013079.1_PE2H4 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:100947-105347:+ | gene-YLL021W_S288C | rna-NM_001181841.1_S288C | cds-NP_013079.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000062.1:3626-8269:+ | gene-YLL021W_SA1 | rna-NM_001181841.1_SA1 | cds-NP_013079.1_SA1 | 94.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:88570-93213:+ | gene-YLL021W_ThermosaccDry | rna-NM_001181841.1_ThermosaccDry | cds-NP_013079.1_ThermosaccDry | 94.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:102383-106864:+ | gene-YLL021W_VR1 | rna-NM_001181841.1_VR1 | cds-NP_013079.1_VR1 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:87890-92533:+ | gene-YLL021W_ZTW1 | rna-NM_001181841.1_ZTW1 | cds-NP_013079.1_ZTW1 | 94.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:96361-100755:+ | gene-YLL021W_Sparadoxus | rna-NM_001181841.1_Sparadoxus | cds-NP_013079.1_Sparadoxus | 84.7 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |