Gene name: SNF1
Reference locus (S288C): YDR477W
Gene biotype: protein_coding
Description: AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase
Top 10 interactors (score): SNF4 (0.999); GAL83 (0.999); SIP2 (0.999); SIP1 (0.999); MIG1 (0.998); SAK1 (0.991); GLC7 (0.988); SIP4 (0.982); REG1 (0.98); HXK2 (0.98); ADR1 (0.977); ACC1 (0.974); SNF3 (0.965); RGT2 (0.964); VPS30 (0.959); MSN2 (0.958); ELM1 (0.955); CAT8 (0.953); VPS34 (0.945); TOR1 (0.943)
Homologues (species, bitscore): PRKAA2 (Homo sapiens, 414.8); Prkaa2 (Mus musculus, 412.1); prkaa1 (Danio rerio, 399.8); prkaa2 (Xenopus tropicalis, 417.5); AMPKalpha (Drosophila melanogaster, 422.2); aak-2 (Caenorhabditis elegans, 397.9); KIN10 (Arabidopsis thaliana, 391.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1352297-1354198:+ | gene-YDR477W_AKU4011 | rna-NM_001180785.3_AKU4011 | cds-NP_010765.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:227396-229303:+ | gene-YDR477W_BG1 | rna-NM_001180785.3_BG1 | cds-NP_010765.3_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1383704-1385605:+ | gene-YDR477W_Bruggeman | rna-NM_001180785.3_Bruggeman | cds-NP_010765.3_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1360846-1362753:+ | gene-YDR477W_CAT1 | rna-NM_001180785.3_CAT1 | cds-NP_010765.3_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1346596-1348497:+ | gene-YDR477W_CBS1585 | rna-NM_001180785.3_CBS1585 | cds-NP_010765.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1365954-1367855:+ | gene-YDR477W_CBS436 | rna-NM_001180785.3_CBS436 | cds-NP_010765.3_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1342220-1344121:+ | gene-YDR477W_CBS6412 | rna-NM_001180785.3_CBS6412 | cds-NP_010765.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1365231-1367132:+ | gene-YDR477W_CBS6413 | rna-NM_001180785.3_CBS6413 | cds-NP_010765.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1411069-1412970:+ | gene-YDR477W_CENPK1137D | rna-NM_001180785.3_CENPK1137D | cds-NP_010765.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1355638-1357539:+ | gene-YDR477W_EthanolRed | rna-NM_001180785.3_EthanolRed | cds-NP_010765.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1359191-1361092:+ | gene-YDR477W_FaliES1 | rna-NM_001180785.3_FaliES1 | cds-NP_010765.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000026.1:57437-59344:+ | gene-YDR477W_JAY291 | rna-NM_001180785.3_JAY291 | cds-NP_010765.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1366195-1368096:+ | gene-YDR477W_MUCL30387 | rna-NM_001180785.3_MUCL30387 | cds-NP_010765.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1348218-1350119:+ | gene-YDR477W_MUCL30388 | rna-NM_001180785.3_MUCL30388 | cds-NP_010765.3_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1338081-1339982:+ | gene-YDR477W_MUCL39482 | rna-NM_001180785.3_MUCL39482 | cds-NP_010765.3_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1280870-1282771:+ | gene-YDR477W_MUCL42920 | rna-NM_001180785.3_MUCL42920 | cds-NP_010765.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1412296-1414197:+ | gene-YDR477W_NCIM3186 | rna-NM_001180785.3_NCIM3186 | cds-NP_010765.3_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1351850-1353751:+ | gene-YDR477W_NCYC1407 | rna-NM_001180785.3_NCYC1407 | cds-NP_010765.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1362689-1364596:+ | gene-YDR477W_PE2H3 | rna-NM_001180785.3_PE2H3 | cds-NP_010765.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1368263-1370170:+ | gene-YDR477W_PE2H4 | rna-NM_001180785.3_PE2H4 | cds-NP_010765.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1412373-1414274:+ | gene-YDR477W_S288C | rna-NM_001180785.3_S288C | cds-NP_010765.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:202884-204791:- | gene-YDR477W_SA1 | rna-NM_001180785.3_SA1 | cds-NP_010765.3_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1363413-1365314:+ | gene-YDR477W_ThermosaccDry | rna-NM_001180785.3_ThermosaccDry | cds-NP_010765.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1379132-1381039:+ | gene-YDR477W_VR1 | rna-NM_001180785.3_VR1 | cds-NP_010765.3_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:406080-407981:+ | gene-YDR477W_ZTW1 | rna-NM_001180785.3_ZTW1 | cds-NP_010765.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1366178-1368079:+ | gene-YDR477W_Sparadoxus | rna-NM_001180785.3_Sparadoxus | cds-NP_010765.3_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |