Gene name: SMC5
Reference locus (S288C): YOL034W
Gene biotype: protein_coding
Description: Structural maintenance of chromosomes protein 5; Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
Top 10 interactors (score): NSE1 (0.999); NSE4 (0.999); SMC3 (0.999); NSE3 (0.999); SMC6 (0.999); MMS21 (0.999); MCD1 (0.999); SMC1 (0.998); SMT3 (0.998); SMC4 (0.998); KRE29 (0.997); IRR1 (0.997); NSE5 (0.996); UBC9 (0.996); SMC2 (0.995); SGS1 (0.992); SCC2 (0.992); ESP1 (0.99); RTT107 (0.989); MPH1 (0.987)
Homologues (species, bitscore): SMC5 (Homo sapiens, 337.4); Smc5 (Mus musculus, 340.1); smc5 (Danio rerio, 299.7); SMC5 (Xenopus tropicalis, 315.5); SMC5 (Drosophila melanogaster, 256.9); smc-5 (Caenorhabditis elegans, 203.8); SMC5 (Arabidopsis thaliana, 260.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:244285-247566:+ | gene-YOL034W_AKU4011 | rna-NM_001183288.1_AKU4011 | cds-NP_014608.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:59905-63186:+ | gene-YOL034W_BG1 | rna-NM_001183288.1_BG1 | cds-NP_014608.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:247138-250419:+ | gene-YOL034W_Bruggeman | rna-NM_001183288.1_Bruggeman | cds-NP_014608.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:245000-248281:+ | gene-YOL034W_CAT1 | rna-NM_001183288.1_CAT1 | cds-NP_014608.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:238955-242236:+ | gene-YOL034W_CBS1585 | rna-NM_001183288.1_CBS1585 | cds-NP_014608.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:243233-246514:+ | gene-YOL034W_CBS436 | rna-NM_001183288.1_CBS436 | cds-NP_014608.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:238319-241600:+ | gene-YOL034W_CBS6412 | rna-NM_001183288.1_CBS6412 | cds-NP_014608.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:245838-249119:+ | gene-YOL034W_CBS6413 | rna-NM_001183288.1_CBS6413 | cds-NP_014608.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:259623-262904:+ | gene-YOL034W_CENPK1137D | rna-NM_001183288.1_CENPK1137D | cds-NP_014608.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:241272-244553:+ | gene-YOL034W_EthanolRed | rna-NM_001183288.1_EthanolRed | cds-NP_014608.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:244188-247469:+ | gene-YOL034W_FaliES1 | rna-NM_001183288.1_FaliES1 | cds-NP_014608.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000018.1:18988-22269:- | gene-YOL034W_JAY291 | rna-NM_001183288.1_JAY291 | cds-NP_014608.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:250160-253441:+ | gene-YOL034W_MUCL30387 | rna-NM_001183288.1_MUCL30387 | cds-NP_014608.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:254512-257793:+ | gene-YOL034W_MUCL30388 | rna-NM_001183288.1_MUCL30388 | cds-NP_014608.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:246440-249721:+ | gene-YOL034W_MUCL39482 | rna-NM_001183288.1_MUCL39482 | cds-NP_014608.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:261372-264653:+ | gene-YOL034W_MUCL42920 | rna-NM_001183288.1_MUCL42920 | cds-NP_014608.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:259812-263093:+ | gene-YOL034W_NCIM3186 | rna-NM_001183288.1_NCIM3186 | cds-NP_014608.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:253180-256461:+ | gene-YOL034W_NCYC1407 | rna-NM_001183288.1_NCYC1407 | cds-NP_014608.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:235598-238879:+ | gene-YOL034W_PE2H3 | rna-NM_001183288.1_PE2H3 | cds-NP_014608.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:246572-249853:+ | gene-YOL034W_PE2H4 | rna-NM_001183288.1_PE2H4 | cds-NP_014608.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:259923-263204:+ | gene-YOL034W_S288C | rna-NM_001183288.1_S288C | cds-NP_014608.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:227923-231204:+ | gene-YOL034W_SA1 | rna-NM_001183288.1_SA1 | cds-NP_014608.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:242759-246040:+ | gene-YOL034W_ThermosaccDry | rna-NM_001183288.1_ThermosaccDry | cds-NP_014608.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:242823-246104:+ | gene-YOL034W_VR1 | rna-NM_001183288.1_VR1 | cds-NP_014608.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:242623-245904:+ | gene-YOL034W_ZTW1 | rna-NM_001183288.1_ZTW1 | cds-NP_014608.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:251027-254308:+ | gene-YOL034W_Sparadoxus | rna-NM_001183288.1_Sparadoxus | cds-NP_014608.1_Sparadoxus | 88.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |