Gene name: SLX8
Reference locus (S288C): YER116C
Gene biotype: protein_coding
Description: Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF
Top 10 interactors (score): SLX5 (0.999); SGS1 (0.957); NFI1 (0.952); UBC4 (0.951); RAD52 (0.937); CDC27 (0.912); SIZ1 (0.909); CDC4 (0.907); ASI3 (0.906); ASI1 (0.906); CDC23 (0.904); APC4 (0.903); MET30 (0.902); DOC1 (0.901); APC11 (0.9); MND2 (0.9); APC9 (0.9); APC1 (0.9); APC2 (0.9); ASI2 (0.9)
Homologues (species, bitscore): RNF10 (Homo sapiens, 57.8); Rnf10 (Mus musculus, 57.8); rnf10 (Danio rerio, 57.4); rnf10 (Xenopus tropicalis, 56.2); CG12099 (Drosophila melanogaster, 55.8); Y38F1A.2 (Caenorhabditis elegans, 51.2); AT2G42030 (Arabidopsis thaliana, 51.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:389224-390048:- | gene-YER116C_AKU4011 | rna-NM_001179006.3_AKU4011 | cds-NP_011041.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:35572-36396:+ | gene-YER116C_BG1 | rna-NM_001179006.3_BG1 | cds-NP_011041.3_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:399696-400520:- | gene-YER116C_Bruggeman | rna-NM_001179006.3_Bruggeman | cds-NP_011041.3_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:394936-395760:- | gene-YER116C_CAT1 | rna-NM_001179006.3_CAT1 | cds-NP_011041.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:388619-389443:- | gene-YER116C_CBS1585 | rna-NM_001179006.3_CBS1585 | cds-NP_011041.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:391326-392150:- | gene-YER116C_CBS436 | rna-NM_001179006.3_CBS436 | cds-NP_011041.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:387697-388521:- | gene-YER116C_CBS6412 | rna-NM_001179006.3_CBS6412 | cds-NP_011041.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:394541-395365:- | gene-YER116C_CBS6413 | rna-NM_001179006.3_CBS6413 | cds-NP_011041.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:393084-393908:- | gene-YER116C_CENPK1137D | rna-NM_001179006.3_CENPK1137D | cds-NP_011041.3_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:389073-389897:- | gene-YER116C_EthanolRed | rna-NM_001179006.3_EthanolRed | cds-NP_011041.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:389554-390378:- | gene-YER116C_FaliES1 | rna-NM_001179006.3_FaliES1 | cds-NP_011041.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000174.1:1166-1990:+ | gene-YER116C_JAY291 | rna-NM_001179006.3_JAY291 | cds-NP_011041.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:396645-397469:- | gene-YER116C_MUCL30387 | rna-NM_001179006.3_MUCL30387 | cds-NP_011041.3_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:391590-392414:- | gene-YER116C_MUCL30388 | rna-NM_001179006.3_MUCL30388 | cds-NP_011041.3_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:387644-388468:- | gene-YER116C_MUCL39482 | rna-NM_001179006.3_MUCL39482 | cds-NP_011041.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:396137-396961:- | gene-YER116C_MUCL42920 | rna-NM_001179006.3_MUCL42920 | cds-NP_011041.3_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:395347-396171:- | gene-YER116C_NCIM3186 | rna-NM_001179006.3_NCIM3186 | cds-NP_011041.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:393177-394001:- | gene-YER116C_NCYC1407 | rna-NM_001179006.3_NCYC1407 | cds-NP_011041.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:403722-404546:- | gene-YER116C_PE2H3 | rna-NM_001179006.3_PE2H3 | cds-NP_011041.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:393663-394487:- | gene-YER116C_PE2H4 | rna-NM_001179006.3_PE2H4 | cds-NP_011041.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:395348-396172:- | gene-YER116C_S288C | rna-NM_001179006.3_S288C | cds-NP_011041.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:104954-105778:- | gene-YER116C_SA1 | rna-NM_001179006.3_SA1 | cds-NP_011041.3_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:390352-391176:- | gene-YER116C_ThermosaccDry | rna-NM_001179006.3_ThermosaccDry | cds-NP_011041.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:391407-392231:- | gene-YER116C_VR1 | rna-NM_001179006.3_VR1 | cds-NP_011041.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:387462-388286:- | gene-YER116C_ZTW1 | rna-NM_001179006.3_ZTW1 | cds-NP_011041.3_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:391395-392213:- | gene-YER116C_Sparadoxus | rna-NM_001179006.3_Sparadoxus | cds-NP_011041.3_Sparadoxus | 83.5 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |