Gene name: SLX4
Reference locus (S288C): YLR135W
Gene biotype: protein_coding
Description: Structure-specific endonuclease subunit SLX4; Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor; Belongs to the SLX4 family
Top 10 interactors (score): RTT107 (0.999); SLX1 (0.998); SGS1 (0.992); DPB11 (0.977); RAD1 (0.969); MMS4 (0.962); MUS81 (0.948); RMI1 (0.92); RAD9 (0.908); RAD53 (0.892); RAD51 (0.892); YEN1 (0.861); SMC5 (0.85); MPH1 (0.849); TOP3 (0.836); ESC2 (0.832); SAE2 (0.822); DOT1 (0.821); SAW1 (0.82); RTT101 (0.817)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:395778-398024:+ | gene-YLR135W_AKU4011 | rna-NM_001182022.1_AKU4011 | cds-NP_013236.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:359545-361791:+ | gene-YLR135W_BG1 | rna-NM_001182022.1_BG1 | cds-NP_013236.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:407644-409890:+ | gene-YLR135W_Bruggeman | rna-NM_001182022.1_Bruggeman | cds-NP_013236.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:407055-409301:+ | gene-YLR135W_CAT1 | rna-NM_001182022.1_CAT1 | cds-NP_013236.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:402922-405168:+ | gene-YLR135W_CBS1585 | rna-NM_001182022.1_CBS1585 | cds-NP_013236.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:393145-395391:+ | gene-YLR135W_CBS436 | rna-NM_001182022.1_CBS436 | cds-NP_013236.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:401339-403585:+ | gene-YLR135W_CBS6412 | rna-NM_001182022.1_CBS6412 | cds-NP_013236.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:403187-405433:+ | gene-YLR135W_CBS6413 | rna-NM_001182022.1_CBS6413 | cds-NP_013236.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:398302-400548:+ | gene-YLR135W_CENPK1137D | rna-NM_001182022.1_CENPK1137D | cds-NP_013236.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:395979-398225:+ | gene-YLR135W_EthanolRed | rna-NM_001182022.1_EthanolRed | cds-NP_013236.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:395490-397736:+ | gene-YLR135W_FaliES1 | rna-NM_001182022.1_FaliES1 | cds-NP_013236.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000061.1:2149-4395:+ | gene-YLR135W_JAY291 | rna-NM_001182022.1_JAY291 | cds-NP_013236.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:407650-409896:+ | gene-YLR135W_MUCL30387 | rna-NM_001182022.1_MUCL30387 | cds-NP_013236.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:412454-414700:+ | gene-YLR135W_MUCL30388 | rna-NM_001182022.1_MUCL30388 | cds-NP_013236.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:403431-405677:+ | gene-YLR135W_MUCL39482 | rna-NM_001182022.1_MUCL39482 | cds-NP_013236.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:403558-405804:+ | gene-YLR135W_MUCL42920 | rna-NM_001182022.1_MUCL42920 | cds-NP_013236.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:413255-415501:+ | gene-YLR135W_NCIM3186 | rna-NM_001182022.1_NCIM3186 | cds-NP_013236.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:395703-397949:+ | gene-YLR135W_NCYC1407 | rna-NM_001182022.1_NCYC1407 | cds-NP_013236.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:401255-403501:+ | gene-YLR135W_PE2H3 | rna-NM_001182022.1_PE2H3 | cds-NP_013236.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:400996-403242:+ | gene-YLR135W_PE2H4 | rna-NM_001182022.1_PE2H4 | cds-NP_013236.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:413281-415527:+ | gene-YLR135W_S288C | rna-NM_001182022.1_S288C | cds-NP_013236.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000055.1:39193-41439:+ | gene-YLR135W_SA1 | rna-NM_001182022.1_SA1 | cds-NP_013236.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:396700-398946:+ | gene-YLR135W_ThermosaccDry | rna-NM_001182022.1_ThermosaccDry | cds-NP_013236.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:409396-411642:+ | gene-YLR135W_VR1 | rna-NM_001182022.1_VR1 | cds-NP_013236.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:394495-396741:+ | gene-YLR135W_ZTW1 | rna-NM_001182022.1_ZTW1 | cds-NP_013236.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:404494-406737:+ | gene-YLR135W_Sparadoxus | rna-NM_001182022.1_Sparadoxus | cds-NP_013236.1_Sparadoxus | 86.4 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |