Gene name: SLD2
Reference locus (S288C): YKL108W
Gene biotype: protein_coding
Description: DNA replication regulator SLD2; Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress; Belongs to the SLD2 family
Top 10 interactors (score): DPB11 (0.999); MCM2 (0.997); CDC45 (0.997); SLD7 (0.995); CDC6 (0.993); SLD3 (0.99); MCM4 (0.989); SLD5 (0.981); PSF3 (0.981); MCM6 (0.977); MCM5 (0.977); ORC6 (0.973); ORC2 (0.973); MCM3 (0.97); PSF1 (0.968); PSF2 (0.964); MCM7 (0.953); CLB5 (0.952); DBF4 (0.936); CDC28 (0.927)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:220987-222339:+ | gene-YKL108W_AKU4011 | rna-NM_001179674.1_AKU4011 | cds-NP_012814.1_AKU4011 | 98.7 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:198114-199466:+ | gene-YKL108W_BG1 | rna-NM_001179674.1_BG1 | cds-NP_012814.1_BG1 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:238913-240261:+ | gene-YKL108W_Bruggeman | rna-NM_001179674.1_Bruggeman | cds-NP_012814.1_Bruggeman | 94.4 | 97.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:233961-235313:+ | gene-YKL108W_CAT1 | rna-NM_001179674.1_CAT1 | cds-NP_012814.1_CAT1 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:233217-234578:+ | gene-YKL108W_CBS1585 | rna-NM_001179674.1_CBS1585 | cds-NP_012814.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:231809-233179:+ | gene-YKL108W_CBS436 | rna-NM_001179674.1_CBS436 | cds-NP_012814.1_CBS436 | 97.4 | 99.7 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:217849-219210:+ | gene-YKL108W_CBS6412 | rna-NM_001179674.1_CBS6412 | cds-NP_012814.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:233683-235035:+ | gene-YKL108W_CBS6413 | rna-NM_001179674.1_CBS6413 | cds-NP_012814.1_CBS6413 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:234067-235428:+ | gene-YKL108W_CENPK1137D | rna-NM_001179674.1_CENPK1137D | cds-NP_012814.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:231660-233030:+ | gene-YKL108W_EthanolRed | rna-NM_001179674.1_EthanolRed | cds-NP_012814.1_EthanolRed | 97.0 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:232473-233843:+ | gene-YKL108W_FaliES1 | rna-NM_001179674.1_FaliES1 | cds-NP_012814.1_FaliES1 | 97.0 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000357.1:54829-56181:+ | gene-YKL108W_JAY291 | rna-NM_001179674.1_JAY291 | cds-NP_012814.1_JAY291 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:240716-242064:+ | gene-YKL108W_MUCL30387 | rna-NM_001179674.1_MUCL30387 | cds-NP_012814.1_MUCL30387 | 94.4 | 97.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:235099-236465:+ | gene-YKL108W_MUCL30388 | rna-NM_001179674.1_MUCL30388 | cds-NP_012814.1_MUCL30388 | 92.5 | 97.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:233014-234366:+ | gene-YKL108W_MUCL39482 | rna-NM_001179674.1_MUCL39482 | cds-NP_012814.1_MUCL39482 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:237391-238761:+ | gene-YKL108W_MUCL42920 | rna-NM_001179674.1_MUCL42920 | cds-NP_012814.1_MUCL42920 | 97.2 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:234415-235776:+ | gene-YKL108W_NCIM3186 | rna-NM_001179674.1_NCIM3186 | cds-NP_012814.1_NCIM3186 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:233205-234557:+ | gene-YKL108W_NCYC1407 | rna-NM_001179674.1_NCYC1407 | cds-NP_012814.1_NCYC1407 | 98.7 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:240302-241654:+ | gene-YKL108W_PE2H3 | rna-NM_001179674.1_PE2H3 | cds-NP_012814.1_PE2H3 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:236589-237941:+ | gene-YKL108W_PE2H4 | rna-NM_001179674.1_PE2H4 | cds-NP_012814.1_PE2H4 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:234426-235787:+ | gene-YKL108W_S288C | rna-NM_001179674.1_S288C | cds-NP_012814.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:150550-151902:+ | gene-YKL108W_SA1 | rna-NM_001179674.1_SA1 | cds-NP_012814.1_SA1 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:233173-234543:+ | gene-YKL108W_ThermosaccDry | rna-NM_001179674.1_ThermosaccDry | cds-NP_012814.1_ThermosaccDry | 97.0 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:232562-233914:+ | gene-YKL108W_VR1 | rna-NM_001179674.1_VR1 | cds-NP_012814.1_VR1 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:231748-233100:+ | gene-YKL108W_ZTW1 | rna-NM_001179674.1_ZTW1 | cds-NP_012814.1_ZTW1 | 98.8 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:248729-250111:+ | gene-YKL108W_Sparadoxus | rna-NM_001179674.1_Sparadoxus | cds-NP_012814.1_Sparadoxus | 83.4 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |