Gene name: SKI3
Reference locus (S288C): YPR189W
Gene biotype: protein_coding
Description: Superkiller protein 3; Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome
Top 10 interactors (score): SKI2 (0.999); SKI8 (0.999); SKI7 (0.996); CSL4 (0.987); XRN1 (0.978); RRP45 (0.977); SKI6 (0.969); RRP46 (0.962); MTR4 (0.96); DIS3 (0.958); RRP40 (0.95); MTR3 (0.949); RRP6 (0.943); RRP42 (0.943); RRP4 (0.885); RPS19A (0.877); LRP1 (0.868); RPL42B (0.867); RPL3 (0.867); DOM34 (0.864)
Homologues (species, bitscore): TTC37 (Homo sapiens, 114.8); Ttc37 (Mus musculus, 117.5); TTC37 (Danio rerio, 119.0); ttc37 (Xenopus tropicalis, 114.8); CG8777 (Drosophila melanogaster, 100.1); AT1G76630 (Arabidopsis thaliana, 70.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:866948-871246:+ | gene-YPR189W_AKU4011 | rna-NM_001184286.1_AKU4011 | cds-NP_015515.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:26475-30773:- | gene-YPR189W_BG1 | rna-NM_001184286.1_BG1 | cds-NP_015515.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:948219-952517:+ | gene-YPR189W_Bruggeman | rna-NM_001184286.1_Bruggeman | cds-NP_015515.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:990279-994577:+ | gene-YPR189W_CAT1 | rna-NM_001184286.1_CAT1 | cds-NP_015515.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:871749-876047:+ | gene-YPR189W_CBS1585 | rna-NM_001184286.1_CBS1585 | cds-NP_015515.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:885287-889585:+ | gene-YPR189W_CBS436 | rna-NM_001184286.1_CBS436 | cds-NP_015515.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:873528-877826:+ | gene-YPR189W_CBS6412 | rna-NM_001184286.1_CBS6412 | cds-NP_015515.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:868673-872971:+ | gene-YPR189W_CBS6413 | rna-NM_001184286.1_CBS6413 | cds-NP_015515.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:912735-917033:+ | gene-YPR189W_CENPK1137D | rna-NM_001184286.1_CENPK1137D | cds-NP_015515.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:1188697-1192995:+ | gene-YPR189W_EthanolRed | rna-NM_001184286.1_EthanolRed | cds-NP_015515.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:868770-873068:+ | gene-YPR189W_FaliES1 | rna-NM_001184286.1_FaliES1 | cds-NP_015515.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000081.1:56066-60364:+ | gene-YPR189W_JAY291 | rna-NM_001184286.1_JAY291 | cds-NP_015515.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:915449-919972:+ | gene-YPR189W_MUCL30387 | rna-NM_001184286.1_MUCL30387 | cds-NP_015515.1_MUCL30387 | 94.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:889581-893879:+ | gene-YPR189W_MUCL30388 | rna-NM_001184286.1_MUCL30388 | cds-NP_015515.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:863950-868248:+ | gene-YPR189W_MUCL39482 | rna-NM_001184286.1_MUCL39482 | cds-NP_015515.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:928407-932954:+ | gene-YPR189W_MUCL42920 | rna-NM_001184286.1_MUCL42920 | cds-NP_015515.1_MUCL42920 | 94.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:912647-916945:+ | gene-YPR189W_NCIM3186 | rna-NM_001184286.1_NCIM3186 | cds-NP_015515.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:872311-876609:+ | gene-YPR189W_NCYC1407 | rna-NM_001184286.1_NCYC1407 | cds-NP_015515.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:884594-888892:+ | gene-YPR189W_PE2H3 | rna-NM_001184286.1_PE2H3 | cds-NP_015515.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:884242-888540:+ | gene-YPR189W_PE2H4 | rna-NM_001184286.1_PE2H4 | cds-NP_015515.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:912664-916962:+ | gene-YPR189W_S288C | rna-NM_001184286.1_S288C | cds-NP_015515.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000060.1:8849-13147:- | gene-YPR189W_SA1 | rna-NM_001184286.1_SA1 | cds-NP_015515.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:868458-872756:+ | gene-YPR189W_ThermosaccDry | rna-NM_001184286.1_ThermosaccDry | cds-NP_015515.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:896247-900545:+ | gene-YPR189W_VR1 | rna-NM_001184286.1_VR1 | cds-NP_015515.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:871003-875301:+ | gene-YPR189W_ZTW1 | rna-NM_001184286.1_ZTW1 | cds-NP_015515.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:873038-877321:+ | gene-YPR189W_Sparadoxus | rna-NM_001184286.1_Sparadoxus | cds-NP_015515.1_Sparadoxus | 89.0 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |