Gene name: SKI2
Reference locus (S288C): YLR398C
Gene biotype: protein_coding
Description: Antiviral helicase SKI2; Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; Belongs to the helicase family. SKI2 subfamily
Top 10 interactors (score): SKI8 (0.999); SKI3 (0.999); SKI7 (0.997); XRN1 (0.994); CSL4 (0.994); RRP45 (0.987); SKI6 (0.987); DOM34 (0.987); DIS3 (0.985); RAT1 (0.983); RRP6 (0.983); MTR3 (0.98); RRP40 (0.976); RRP46 (0.975); RRP43 (0.964); RRP42 (0.963); RRP4 (0.948); LSM1 (0.938); TRF5 (0.917); PAP2 (0.914)
Homologues (species, bitscore): SKIV2L (Homo sapiens, 751.9); Skiv2l (Mus musculus, 756.9); skiv2l (Danio rerio, 778.5); skiv2l (Xenopus tropicalis, 753.4); tst (Drosophila melanogaster, 699.5); skih-2 (Caenorhabditis elegans, 676.4); AT3G46960 (Arabidopsis thaliana, 743.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:864690-868553:- | gene-YLR398C_AKU4011 | rna-NM_001182286.3_AKU4011 | cds-NP_013502.3_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:96834-100697:- | gene-YLR398C_BG1 | rna-NM_001182286.3_BG1 | cds-NP_013502.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:902995-906858:- | gene-YLR398C_Bruggeman | rna-NM_001182286.3_Bruggeman | cds-NP_013502.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:898520-902383:- | gene-YLR398C_CAT1 | rna-NM_001182286.3_CAT1 | cds-NP_013502.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:900286-904149:- | gene-YLR398C_CBS1585 | rna-NM_001182286.3_CBS1585 | cds-NP_013502.3_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:883925-887788:- | gene-YLR398C_CBS436 | rna-NM_001182286.3_CBS436 | cds-NP_013502.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:936327-940190:- | gene-YLR398C_CBS6412 | rna-NM_001182286.3_CBS6412 | cds-NP_013502.3_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:900577-904440:- | gene-YLR398C_CBS6413 | rna-NM_001182286.3_CBS6413 | cds-NP_013502.3_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:899967-903830:- | gene-YLR398C_CENPK1137D | rna-NM_001182286.3_CENPK1137D | cds-NP_013502.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:857233-861096:- | gene-YLR398C_EthanolRed | rna-NM_001182286.3_EthanolRed | cds-NP_013502.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:886543-890406:- | gene-YLR398C_FaliES1 | rna-NM_001182286.3_FaliES1 | cds-NP_013502.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:39702-43565:- | gene-YLR398C_JAY291 | rna-NM_001182286.3_JAY291 | cds-NP_013502.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:901861-905724:- | gene-YLR398C_MUCL30387 | rna-NM_001182286.3_MUCL30387 | cds-NP_013502.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:907947-911810:- | gene-YLR398C_MUCL30388 | rna-NM_001182286.3_MUCL30388 | cds-NP_013502.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:901506-905369:- | gene-YLR398C_MUCL39482 | rna-NM_001182286.3_MUCL39482 | cds-NP_013502.3_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:896162-900025:- | gene-YLR398C_MUCL42920 | rna-NM_001182286.3_MUCL42920 | cds-NP_013502.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:915130-918993:- | gene-YLR398C_NCIM3186 | rna-NM_001182286.3_NCIM3186 | cds-NP_013502.3_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:910686-914549:- | gene-YLR398C_NCYC1407 | rna-NM_001182286.3_NCYC1407 | cds-NP_013502.3_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:897083-900946:- | gene-YLR398C_PE2H3 | rna-NM_001182286.3_PE2H3 | cds-NP_013502.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:896827-900690:- | gene-YLR398C_PE2H4 | rna-NM_001182286.3_PE2H4 | cds-NP_013502.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:915156-919019:- | gene-YLR398C_S288C | rna-NM_001182286.3_S288C | cds-NP_013502.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:129669-133532:+ | gene-YLR398C_SA1 | rna-NM_001182286.3_SA1 | cds-NP_013502.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:889622-893485:- | gene-YLR398C_ThermosaccDry | rna-NM_001182286.3_ThermosaccDry | cds-NP_013502.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:902173-906036:- | gene-YLR398C_VR1 | rna-NM_001182286.3_VR1 | cds-NP_013502.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:226340-230203:- | gene-YLR398C_ZTW1 | rna-NM_001182286.3_ZTW1 | cds-NP_013502.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:875051-878914:- | gene-YLR398C_Sparadoxus | rna-NM_001182286.3_Sparadoxus | cds-NP_013502.3_Sparadoxus | 90.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |