Gene name: SIZ1
Reference locus (S288C): YDR409W
Gene biotype: protein_coding
Description: SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p
Top 10 interactors (score): SMT3 (0.999); UBC9 (0.999); POL30 (0.997); MMS21 (0.995); RAD18 (0.983); UBA2 (0.981); ULP2 (0.979); ULP1 (0.977); AOS1 (0.967); RAD52 (0.967); UBC13 (0.961); SRS2 (0.956); RAD5 (0.956); NFI1 (0.955); RAD6 (0.949); CST9 (0.943); RAD51 (0.923); SLX8 (0.909); SLX5 (0.906); SMC5 (0.902)
Homologues (species, bitscore): PIAS4 (Homo sapiens, 103.6); Pias4 (Mus musculus, 107.5); pias4a (Danio rerio, 110.5); pias4 (Xenopus tropicalis, 99.8); CG8068 (Drosophila melanogaster, 96.3); gei-17 (Caenorhabditis elegans, 100.1); AT5G41580 (Arabidopsis thaliana, 84.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1229559-1232273:+ | gene-YDR409W_AKU4011 | rna-NM_001180717.3_AKU4011 | cds-NP_010697.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:108042-110756:+ | gene-YDR409W_BG1 | rna-NM_001180717.3_BG1 | cds-NP_010697.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1260437-1263154:+ | gene-YDR409W_Bruggeman | rna-NM_001180717.3_Bruggeman | cds-NP_010697.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1239000-1241714:+ | gene-YDR409W_CAT1 | rna-NM_001180717.3_CAT1 | cds-NP_010697.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1224479-1227193:+ | gene-YDR409W_CBS1585 | rna-NM_001180717.3_CBS1585 | cds-NP_010697.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1243338-1246052:+ | gene-YDR409W_CBS436 | rna-NM_001180717.3_CBS436 | cds-NP_010697.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1220533-1223247:+ | gene-YDR409W_CBS6412 | rna-NM_001180717.3_CBS6412 | cds-NP_010697.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1242388-1245102:+ | gene-YDR409W_CBS6413 | rna-NM_001180717.3_CBS6413 | cds-NP_010697.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1288065-1290779:+ | gene-YDR409W_CENPK1137D | rna-NM_001180717.3_CENPK1137D | cds-NP_010697.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1233961-1236678:+ | gene-YDR409W_EthanolRed | rna-NM_001180717.3_EthanolRed | cds-NP_010697.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1237271-1239985:+ | gene-YDR409W_FaliES1 | rna-NM_001180717.3_FaliES1 | cds-NP_010697.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000181.1:15545-18259:- | gene-YDR409W_JAY291 | rna-NM_001180717.3_JAY291 | cds-NP_010697.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1243999-1246716:+ | gene-YDR409W_MUCL30387 | rna-NM_001180717.3_MUCL30387 | cds-NP_010697.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1226105-1228822:+ | gene-YDR409W_MUCL30388 | rna-NM_001180717.3_MUCL30388 | cds-NP_010697.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1215807-1218521:+ | gene-YDR409W_MUCL39482 | rna-NM_001180717.3_MUCL39482 | cds-NP_010697.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1158238-1160952:+ | gene-YDR409W_MUCL42920 | rna-NM_001180717.3_MUCL42920 | cds-NP_010697.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1289329-1292043:+ | gene-YDR409W_NCIM3186 | rna-NM_001180717.3_NCIM3186 | cds-NP_010697.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1229779-1232493:+ | gene-YDR409W_NCYC1407 | rna-NM_001180717.3_NCYC1407 | cds-NP_010697.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1239911-1242625:+ | gene-YDR409W_PE2H3 | rna-NM_001180717.3_PE2H3 | cds-NP_010697.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1245479-1248193:+ | gene-YDR409W_PE2H4 | rna-NM_001180717.3_PE2H4 | cds-NP_010697.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1289406-1292120:+ | gene-YDR409W_S288C | rna-NM_001180717.3_S288C | cds-NP_010697.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000071.1:15667-18381:- | gene-YDR409W_SA1 | rna-NM_001180717.3_SA1 | cds-NP_010697.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1241533-1244247:+ | gene-YDR409W_ThermosaccDry | rna-NM_001180717.3_ThermosaccDry | cds-NP_010697.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1256718-1259432:+ | gene-YDR409W_VR1 | rna-NM_001180717.3_VR1 | cds-NP_010697.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:284328-287042:+ | gene-YDR409W_ZTW1 | rna-NM_001180717.3_ZTW1 | cds-NP_010697.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1236782-1239478:+ | gene-YDR409W_Sparadoxus | rna-NM_001180717.3_Sparadoxus | cds-NP_010697.3_Sparadoxus | 84.6 | 97.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |