Gene name: SIT4
Reference locus (S288C): YDL047W
Gene biotype: protein_coding
Description: Serine/threonine-protein phosphatase PP1-1; Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6; Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily
Top 10 interactors (score): CDC55 (0.999); SAP155 (0.999); SAP185 (0.999); RRD1 (0.999); TAP42 (0.999); SAP190 (0.999); TPD3 (0.998); RRD2 (0.997); SAP4 (0.995); TIP41 (0.976); SDS22 (0.972); PPH21 (0.972); RTS1 (0.962); GAC1 (0.955); PSY2 (0.955); CNB1 (0.949); REG1 (0.948); SIS2 (0.943); TOR1 (0.936); PSY4 (0.936)
Homologues (species, bitscore): PPP4C (Homo sapiens, 407.5); Ppp6c (Mus musculus, 409.1); ppp6c (Danio rerio, 409.1); ppp6c (Xenopus tropicalis, 409.1); Pp4-19C (Drosophila melanogaster, 404.4); pph-4.1 (Caenorhabditis elegans, 390.2); FYPP3 (Arabidopsis thaliana, 417.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:354394-355329:+ | gene-YDL047W_AKU4011 | rna-NM_001180106.1_AKU4011 | cds-NP_010236.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:194435-195370:- | gene-YDL047W_BG1 | rna-NM_001180106.1_BG1 | cds-NP_010236.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:372156-373091:+ | gene-YDL047W_Bruggeman | rna-NM_001180106.1_Bruggeman | cds-NP_010236.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:369095-370030:+ | gene-YDL047W_CAT1 | rna-NM_001180106.1_CAT1 | cds-NP_010236.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:352642-353577:+ | gene-YDL047W_CBS1585 | rna-NM_001180106.1_CBS1585 | cds-NP_010236.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:369316-370251:+ | gene-YDL047W_CBS436 | rna-NM_001180106.1_CBS436 | cds-NP_010236.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:350351-351286:+ | gene-YDL047W_CBS6412 | rna-NM_001180106.1_CBS6412 | cds-NP_010236.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:370671-371606:+ | gene-YDL047W_CBS6413 | rna-NM_001180106.1_CBS6413 | cds-NP_010236.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:368572-369507:+ | gene-YDL047W_CENPK1137D | rna-NM_001180106.1_CENPK1137D | cds-NP_010236.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:365177-366112:+ | gene-YDL047W_EthanolRed | rna-NM_001180106.1_EthanolRed | cds-NP_010236.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:371405-372340:+ | gene-YDL047W_FaliES1 | rna-NM_001180106.1_FaliES1 | cds-NP_010236.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000035.1:85689-86624:+ | gene-YDL047W_JAY291 | rna-NM_001180106.1_JAY291 | cds-NP_010236.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:369535-370470:+ | gene-YDL047W_MUCL30387 | rna-NM_001180106.1_MUCL30387 | cds-NP_010236.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:360658-361593:+ | gene-YDL047W_MUCL30388 | rna-NM_001180106.1_MUCL30388 | cds-NP_010236.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:353848-354783:+ | gene-YDL047W_MUCL39482 | rna-NM_001180106.1_MUCL39482 | cds-NP_010236.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:275757-276692:+ | gene-YDL047W_MUCL42920 | rna-NM_001180106.1_MUCL42920 | cds-NP_010236.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:369694-370629:+ | gene-YDL047W_NCIM3186 | rna-NM_001180106.1_NCIM3186 | cds-NP_010236.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:353729-354664:+ | gene-YDL047W_NCYC1407 | rna-NM_001180106.1_NCYC1407 | cds-NP_010236.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:360909-361844:+ | gene-YDL047W_PE2H3 | rna-NM_001180106.1_PE2H3 | cds-NP_010236.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:360909-361844:+ | gene-YDL047W_PE2H4 | rna-NM_001180106.1_PE2H4 | cds-NP_010236.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:369771-370706:+ | gene-YDL047W_S288C | rna-NM_001180106.1_S288C | cds-NP_010236.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:64218-65153:- | gene-YDL047W_SA1 | rna-NM_001180106.1_SA1 | cds-NP_010236.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:370867-371802:+ | gene-YDL047W_ThermosaccDry | rna-NM_001180106.1_ThermosaccDry | cds-NP_010236.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:373766-374701:+ | gene-YDL047W_VR1 | rna-NM_001180106.1_VR1 | cds-NP_010236.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:368808-369743:+ | gene-YDL047W_ZTW1 | rna-NM_001180106.1_ZTW1 | cds-NP_010236.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:371254-372189:+ | gene-YDL047W_Sparadoxus | rna-NM_001180106.1_Sparadoxus | cds-NP_010236.1_Sparadoxus | 92.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |