Gene name: SIS2
Reference locus (S288C): YKR072C
Gene biotype: protein_coding
Description: Phosphopantothenoylcysteine decarboxylase subunit SIS2; Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication
Top 10 interactors (score): VHS3 (0.999); PPZ1 (0.999); CAB3 (0.993); CAB5 (0.986); CAB2 (0.985); CAB4 (0.985); PPZ2 (0.952); SIT4 (0.943); ENA1 (0.92); TRK1 (0.904); NHA1 (0.875); SAT4 (0.837); TRK2 (0.827); HAL1 (0.812); HAL5 (0.745); CAB1 (0.728); YML079W (0.721); YPI1 (0.676); PTC1 (0.671); CKA2 (0.655)
Homologues (species, bitscore): PPCDC (Homo sapiens, 141.7); Ppcdc (Mus musculus, 141.0); ppcdc (Danio rerio, 149.8); ppcdc (Xenopus tropicalis, 128.3); Ppcdc (Drosophila melanogaster, 120.6); F25H9.6 (Caenorhabditis elegans, 131.0); HAL3A (Arabidopsis thaliana, 129.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:562479-564158:- | gene-YKR072C_AKU4011 | rna-NM_001179862.1_AKU4011 | cds-NP_012998.1_AKU4011 | 99.1 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:80120-81799:+ | gene-YKR072C_BG1 | rna-NM_001179862.1_BG1 | cds-NP_012998.1_BG1 | 98.8 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:583916-585592:- | gene-YKR072C_Bruggeman | rna-NM_001179862.1_Bruggeman | cds-NP_012998.1_Bruggeman | 98.8 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:580324-582006:- | gene-YKR072C_CAT1 | rna-NM_001179862.1_CAT1 | cds-NP_012998.1_CAT1 | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:574972-576645:- | gene-YKR072C_CBS1585 | rna-NM_001179862.1_CBS1585 | cds-NP_012998.1_CBS1585 | 98.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:573299-574978:- | gene-YKR072C_CBS436 | rna-NM_001179862.1_CBS436 | cds-NP_012998.1_CBS436 | 98.8 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:558260-559933:- | gene-YKR072C_CBS6412 | rna-NM_001179862.1_CBS6412 | cds-NP_012998.1_CBS6412 | 98.9 | 99.1 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:574790-576463:- | gene-YKR072C_CBS6413 | rna-NM_001179862.1_CBS6413 | cds-NP_012998.1_CBS6413 | 98.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:576101-577777:- | gene-YKR072C_CENPK1137D | rna-NM_001179862.1_CENPK1137D | cds-NP_012998.1_CENPK1137D | 99.0 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:571789-573471:- | gene-YKR072C_EthanolRed | rna-NM_001179862.1_EthanolRed | cds-NP_012998.1_EthanolRed | 99.5 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:575689-577371:- | gene-YKR072C_FaliES1 | rna-NM_001179862.1_FaliES1 | cds-NP_012998.1_FaliES1 | 99.5 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000410.1:862-2550:+ | gene-YKR072C_JAY291 | rna-NM_001179862.1_JAY291 | cds-NP_012998.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:584300-585979:- | gene-YKR072C_MUCL30387 | rna-NM_001179862.1_MUCL30387 | cds-NP_012998.1_MUCL30387 | 98.8 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:578901-580574:- | gene-YKR072C_MUCL30388 | rna-NM_001179862.1_MUCL30388 | cds-NP_012998.1_MUCL30388 | 98.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:573801-575486:- | gene-YKR072C_MUCL39482 | rna-NM_001179862.1_MUCL39482 | cds-NP_012998.1_MUCL39482 | 99.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:579823-581502:- | gene-YKR072C_MUCL42920 | rna-NM_001179862.1_MUCL42920 | cds-NP_012998.1_MUCL42920 | 98.8 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:576424-578112:- | gene-YKR072C_NCIM3186 | rna-NM_001179862.1_NCIM3186 | cds-NP_012998.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:574222-575895:- | gene-YKR072C_NCYC1407 | rna-NM_001179862.1_NCYC1407 | cds-NP_012998.1_NCYC1407 | 98.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:599377-601065:- | gene-YKR072C_PE2H3 | rna-NM_001179862.1_PE2H3 | cds-NP_012998.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:583761-585440:- | gene-YKR072C_PE2H4 | rna-NM_001179862.1_PE2H4 | cds-NP_012998.1_PE2H4 | 98.8 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:576435-578123:- | gene-YKR072C_S288C | rna-NM_001179862.1_S288C | cds-NP_012998.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000029.1:103729-105411:+ | gene-YKR072C_SA1 | rna-NM_001179862.1_SA1 | cds-NP_012998.1_SA1 | 99.1 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:574928-576610:- | gene-YKR072C_ThermosaccDry | rna-NM_001179862.1_ThermosaccDry | cds-NP_012998.1_ThermosaccDry | 99.5 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:574687-576375:- | gene-YKR072C_VR1 | rna-NM_001179862.1_VR1 | cds-NP_012998.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:572416-574095:- | gene-YKR072C_ZTW1 | rna-NM_001179862.1_ZTW1 | cds-NP_012998.1_ZTW1 | 99.3 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:597817-599502:- | gene-YKR072C_Sparadoxus | rna-NM_001179862.1_Sparadoxus | cds-NP_012998.1_Sparadoxus | 87.1 | 98.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |