Gene name: SIS1
Reference locus (S288C): YNL007C
Gene biotype: protein_coding
Description: Protein SIS1; Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1
Top 10 interactors (score): SSE1 (0.999); STI1 (0.999); HSP104 (0.999); SSA1 (0.999); SSA2 (0.998); SSE2 (0.998); HSP82 (0.998); HSP78 (0.998); SSA4 (0.997); FES1 (0.997); HSC82 (0.996); SSA3 (0.995); RNQ1 (0.995); AHA1 (0.991); CPR6 (0.991); HSP42 (0.99); HSP10 (0.987); CUR1 (0.984); SUP35 (0.983); BTN2 (0.983)
Homologues (species, bitscore): DNAJB1 (Homo sapiens, 212.6); Dnajb4 (Mus musculus, 214.2); dnajb1b (Danio rerio, 216.1); dnajb1 (Xenopus tropicalis, 251.5); CG5001 (Drosophila melanogaster, 191.0); dnj-13 (Caenorhabditis elegans, 233.0); AT2G20560 (Arabidopsis thaliana, 216.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:601514-602656:- | gene-YNL007C_AKU4011 | rna-NM_001182846.1_AKU4011 | cds-NP_014391.1_AKU4011 | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:503960-505081:- | gene-YNL007C_BG1 | rna-NM_001182846.1_BG1 | cds-NP_014391.1_BG1 | 94.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:618391-619470:- | gene-YNL007C_Bruggeman | rna-NM_001182846.1_Bruggeman | cds-NP_014391.1_Bruggeman | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:653753-654853:- | gene-YNL007C_CAT1 | rna-NM_001182846.1_CAT1 | cds-NP_014391.1_CAT1 | 96.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:607211-608353:- | gene-YNL007C_CBS1585 | rna-NM_001182846.1_CBS1585 | cds-NP_014391.1_CBS1585 | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:669263-670384:- | gene-YNL007C_CBS436 | rna-NM_001182846.1_CBS436 | cds-NP_014391.1_CBS436 | 94.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:597019-598161:- | gene-YNL007C_CBS6412 | rna-NM_001182846.1_CBS6412 | cds-NP_014391.1_CBS6412 | 92.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:598182-599324:- | gene-YNL007C_CBS6413 | rna-NM_001182846.1_CBS6413 | cds-NP_014391.1_CBS6413 | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:612157-613215:- | gene-YNL007C_CENPK1137D | rna-NM_001182846.1_CENPK1137D | cds-NP_014391.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:603581-604723:- | gene-YNL007C_EthanolRed | rna-NM_001182846.1_EthanolRed | cds-NP_014391.1_EthanolRed | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:594350-595492:- | gene-YNL007C_FaliES1 | rna-NM_001182846.1_FaliES1 | cds-NP_014391.1_FaliES1 | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000008.1:12492-13613:+ | gene-YNL007C_JAY291 | rna-NM_001182846.1_JAY291 | cds-NP_014391.1_JAY291 | 94.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:616480-617559:- | gene-YNL007C_MUCL30387 | rna-NM_001182846.1_MUCL30387 | cds-NP_014391.1_MUCL30387 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:657310-658389:- | gene-YNL007C_MUCL30388 | rna-NM_001182846.1_MUCL30388 | cds-NP_014391.1_MUCL30388 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:598719-599861:- | gene-YNL007C_MUCL39482 | rna-NM_001182846.1_MUCL39482 | cds-NP_014391.1_MUCL39482 | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:602574-603653:- | gene-YNL007C_MUCL42920 | rna-NM_001182846.1_MUCL42920 | cds-NP_014391.1_MUCL42920 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:618476-619534:- | gene-YNL007C_NCIM3186 | rna-NM_001182846.1_NCIM3186 | cds-NP_014391.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:600972-602114:- | gene-YNL007C_NCYC1407 | rna-NM_001182846.1_NCYC1407 | cds-NP_014391.1_NCYC1407 | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:602952-604031:- | gene-YNL007C_PE2H3 | rna-NM_001182846.1_PE2H3 | cds-NP_014391.1_PE2H3 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:604270-605349:- | gene-YNL007C_PE2H4 | rna-NM_001182846.1_PE2H4 | cds-NP_014391.1_PE2H4 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:618507-619565:- | gene-YNL007C_S288C | rna-NM_001182846.1_S288C | cds-NP_014391.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000068.1:16177-17256:- | gene-YNL007C_SA1 | rna-NM_001182846.1_SA1 | cds-NP_014391.1_SA1 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:594690-595832:- | gene-YNL007C_ThermosaccDry | rna-NM_001182846.1_ThermosaccDry | cds-NP_014391.1_ThermosaccDry | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:637297-638376:- | gene-YNL007C_VR1 | rna-NM_001182846.1_VR1 | cds-NP_014391.1_VR1 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:503567-504646:- | gene-YNL007C_ZTW1 | rna-NM_001182846.1_ZTW1 | cds-NP_014391.1_ZTW1 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:609735-610826:- | gene-YNL007C_Sparadoxus | rna-NM_001182846.1_Sparadoxus | cds-NP_014391.1_Sparadoxus | 89.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |