Gene name: SIR4
Reference locus (S288C): YDR227W
Gene biotype: protein_coding
Description: Regulatory protein SIR4; SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some alleles of SIR4 prolong lifespan; required for telomere hypercluster formation in quiescent yeast cells
Top 10 interactors (score): SIR2 (0.999); SIR3 (0.999); SIR1 (0.999); YKU80 (0.999); ESC1 (0.999); RAP1 (0.998); YKU70 (0.993); HHF1 (0.983); CDC14 (0.97); HHT1 (0.962); UBP10 (0.954); NET1 (0.942); RIF2 (0.922); UBP3 (0.921); SAN1 (0.92); MPS3 (0.906); CDC13 (0.89); HHF2 (0.889); SAS2 (0.886); SUM1 (0.885)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:874273-878349:+ | gene-YDR227W_AKU4011 | rna-NM_001180535.1_AKU4011 | cds-NP_010513.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:247485-251561:- | gene-YDR227W_BG1 | rna-NM_001180535.1_BG1 | cds-NP_010513.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:906590-910666:+ | gene-YDR227W_Bruggeman | rna-NM_001180535.1_Bruggeman | cds-NP_010513.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:893867-897943:+ | gene-YDR227W_CAT1 | rna-NM_001180535.1_CAT1 | cds-NP_010513.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:864624-868700:+ | gene-YDR227W_CBS1585 | rna-NM_001180535.1_CBS1585 | cds-NP_010513.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:893632-897708:+ | gene-YDR227W_CBS436 | rna-NM_001180535.1_CBS436 | cds-NP_010513.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:861382-865458:+ | gene-YDR227W_CBS6412 | rna-NM_001180535.1_CBS6412 | cds-NP_010513.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:891984-896060:+ | gene-YDR227W_CBS6413 | rna-NM_001180535.1_CBS6413 | cds-NP_010513.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:916371-920447:+ | gene-YDR227W_CENPK1137D | rna-NM_001180535.1_CENPK1137D | cds-NP_010513.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:874964-879040:+ | gene-YDR227W_EthanolRed | rna-NM_001180535.1_EthanolRed | cds-NP_010513.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:883166-887242:+ | gene-YDR227W_FaliES1 | rna-NM_001180535.1_FaliES1 | cds-NP_010513.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000348.1:24329-28405:- | gene-YDR227W_JAY291 | rna-NM_001180535.1_JAY291 | cds-NP_010513.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:892239-896315:+ | gene-YDR227W_MUCL30387 | rna-NM_001180535.1_MUCL30387 | cds-NP_010513.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:880493-884569:+ | gene-YDR227W_MUCL30388 | rna-NM_001180535.1_MUCL30388 | cds-NP_010513.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:866027-870103:+ | gene-YDR227W_MUCL39482 | rna-NM_001180535.1_MUCL39482 | cds-NP_010513.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:805312-809388:+ | gene-YDR227W_MUCL42920 | rna-NM_001180535.1_MUCL42920 | cds-NP_010513.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:917494-921570:+ | gene-YDR227W_NCIM3186 | rna-NM_001180535.1_NCIM3186 | cds-NP_010513.1_NCIM3186 | 98.6 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:869697-873773:+ | gene-YDR227W_NCYC1407 | rna-NM_001180535.1_NCYC1407 | cds-NP_010513.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:885926-890002:+ | gene-YDR227W_PE2H3 | rna-NM_001180535.1_PE2H3 | cds-NP_010513.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:891205-895281:+ | gene-YDR227W_PE2H4 | rna-NM_001180535.1_PE2H4 | cds-NP_010513.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:917571-921647:+ | gene-YDR227W_S288C | rna-NM_001180535.1_S288C | cds-NP_010513.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:123679-127755:+ | gene-YDR227W_SA1 | rna-NM_001180535.1_SA1 | cds-NP_010513.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:881320-885396:+ | gene-YDR227W_ThermosaccDry | rna-NM_001180535.1_ThermosaccDry | cds-NP_010513.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:896528-900604:+ | gene-YDR227W_VR1 | rna-NM_001180535.1_VR1 | cds-NP_010513.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:144036-148112:+ | gene-YDR227W_ZTW1 | rna-NM_001180535.1_ZTW1 | cds-NP_010513.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:886333-890408:+ | gene-YDR227W_Sparadoxus | rna-NM_001180535.1_Sparadoxus | cds-NP_010513.1_Sparadoxus | 80.6 | 99.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |