Gene name: SIR3
Reference locus (S288C): YLR442C
Gene biotype: protein_coding
Description: Regulatory protein SIR3; Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication
Top 10 interactors (score): RAP1 (0.999); SIR2 (0.999); HHT1 (0.999); HHF1 (0.999); SIR1 (0.999); SIR4 (0.999); HHT2 (0.998); ORC5 (0.998); ORC3 (0.997); HHF2 (0.996); CDC6 (0.993); MCM4 (0.989); MCM2 (0.988); HTB1 (0.987); HTA2 (0.986); MCM3 (0.985); MCM5 (0.985); ORC4 (0.984); MCM6 (0.982); CDC45 (0.981)
Homologues (species, bitscore): ORC1 (Homo sapiens, 57.0); Orc1 (Mus musculus, 53.9); orc1 (Danio rerio, 61.2); orc1 (Xenopus tropicalis, 64.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:957580-960516:- | gene-YLR442C_AKU4011 | rna-NM_001182330.3_AKU4011 | cds-NP_013547.3_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:190047-192983:- | gene-YLR442C_BG1 | rna-NM_001182330.3_BG1 | cds-NP_013547.3_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:995891-998827:- | gene-YLR442C_Bruggeman | rna-NM_001182330.3_Bruggeman | cds-NP_013547.3_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:991893-994829:- | gene-YLR442C_CAT1 | rna-NM_001182330.3_CAT1 | cds-NP_013547.3_CAT1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:993174-996110:- | gene-YLR442C_CBS1585 | rna-NM_001182330.3_CBS1585 | cds-NP_013547.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:982524-985460:- | gene-YLR442C_CBS436 | rna-NM_001182330.3_CBS436 | cds-NP_013547.3_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:1029212-1032148:- | gene-YLR442C_CBS6412 | rna-NM_001182330.3_CBS6412 | cds-NP_013547.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:993960-996896:- | gene-YLR442C_CBS6413 | rna-NM_001182330.3_CBS6413 | cds-NP_013547.3_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:1003931-1006867:- | gene-YLR442C_CENPK1137D | rna-NM_001182330.3_CENPK1137D | cds-NP_013547.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:950603-953539:- | gene-YLR442C_EthanolRed | rna-NM_001182330.3_EthanolRed | cds-NP_013547.3_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:985874-988810:- | gene-YLR442C_FaliES1 | rna-NM_001182330.3_FaliES1 | cds-NP_013547.3_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000194.1:29871-32807:+ | gene-YLR442C_JAY291 | rna-NM_001182330.3_JAY291 | cds-NP_013547.3_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:994743-997679:- | gene-YLR442C_MUCL30387 | rna-NM_001182330.3_MUCL30387 | cds-NP_013547.3_MUCL30387 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:1002100-1005036:- | gene-YLR442C_MUCL30388 | rna-NM_001182330.3_MUCL30388 | cds-NP_013547.3_MUCL30388 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:994394-997330:- | gene-YLR442C_MUCL39482 | rna-NM_001182330.3_MUCL39482 | cds-NP_013547.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:994891-997827:- | gene-YLR442C_MUCL42920 | rna-NM_001182330.3_MUCL42920 | cds-NP_013547.3_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:1019289-1022225:- | gene-YLR442C_NCIM3186 | rna-NM_001182330.3_NCIM3186 | cds-NP_013547.3_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:1003825-1006761:- | gene-YLR442C_NCYC1407 | rna-NM_001182330.3_NCYC1407 | cds-NP_013547.3_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:990279-993215:- | gene-YLR442C_PE2H3 | rna-NM_001182330.3_PE2H3 | cds-NP_013547.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:990023-992959:- | gene-YLR442C_PE2H4 | rna-NM_001182330.3_PE2H4 | cds-NP_013547.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:1019315-1022251:- | gene-YLR442C_S288C | rna-NM_001182330.3_S288C | cds-NP_013547.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:37699-40635:+ | gene-YLR442C_SA1 | rna-NM_001182330.3_SA1 | cds-NP_013547.3_SA1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:988953-991889:- | gene-YLR442C_ThermosaccDry | rna-NM_001182330.3_ThermosaccDry | cds-NP_013547.3_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:995383-998319:- | gene-YLR442C_VR1 | rna-NM_001182330.3_VR1 | cds-NP_013547.3_VR1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:319225-322161:- | gene-YLR442C_ZTW1 | rna-NM_001182330.3_ZTW1 | cds-NP_013547.3_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:968266-971238:- | gene-YLR442C_Sparadoxus | rna-NM_001182330.3_Sparadoxus | cds-NP_013547.3_Sparadoxus | 84.9 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |