Gene name: SIR2
Reference locus (S288C): YDL042C
Gene biotype: protein_coding
Description: Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
Top 10 interactors (score): CDC14 (0.999); SIR3 (0.999); SIR1 (0.999); SIR4 (0.999); NET1 (0.999); FOB1 (0.997); HHF1 (0.996); PNC1 (0.995); HHT2 (0.995); RPD3 (0.995); SUM1 (0.988); HHT1 (0.986); YKU70 (0.986); SET1 (0.979); PNP1 (0.979); URH1 (0.977); HTB1 (0.975); MCM10 (0.974); GCN5 (0.972); DOT1 (0.968)
Homologues (species, bitscore): SIRT1 (Homo sapiens, 223.4); Sirt1 (Mus musculus, 222.6); sirt1 (Danio rerio, 236.5); sirt1 (Xenopus tropicalis, 228.4); Sir2 (Drosophila melanogaster, 243.4); sir-2.1 (Caenorhabditis elegans, 207.6); SRT2 (Arabidopsis thaliana, 69.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:361380-363068:- | gene-YDL042C_AKU4011 | rna-NM_001180101.1_AKU4011 | cds-NP_010242.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:186636-188324:+ | gene-YDL042C_BG1 | rna-NM_001180101.1_BG1 | cds-NP_010242.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:379861-381549:- | gene-YDL042C_Bruggeman | rna-NM_001180101.1_Bruggeman | cds-NP_010242.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:376079-377767:- | gene-YDL042C_CAT1 | rna-NM_001180101.1_CAT1 | cds-NP_010242.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:359630-361318:- | gene-YDL042C_CBS1585 | rna-NM_001180101.1_CBS1585 | cds-NP_010242.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:376298-377986:- | gene-YDL042C_CBS436 | rna-NM_001180101.1_CBS436 | cds-NP_010242.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:357337-359025:- | gene-YDL042C_CBS6412 | rna-NM_001180101.1_CBS6412 | cds-NP_010242.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:377669-379357:- | gene-YDL042C_CBS6413 | rna-NM_001180101.1_CBS6413 | cds-NP_010242.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:375617-377305:- | gene-YDL042C_CENPK1137D | rna-NM_001180101.1_CENPK1137D | cds-NP_010242.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:372164-373852:- | gene-YDL042C_EthanolRed | rna-NM_001180101.1_EthanolRed | cds-NP_010242.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:378392-380080:- | gene-YDL042C_FaliES1 | rna-NM_001180101.1_FaliES1 | cds-NP_010242.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000097.1:5710-7398:+ | gene-YDL042C_JAY291 | rna-NM_001180101.1_JAY291 | cds-NP_010242.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:376528-378216:- | gene-YDL042C_MUCL30387 | rna-NM_001180101.1_MUCL30387 | cds-NP_010242.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:367646-369334:- | gene-YDL042C_MUCL30388 | rna-NM_001180101.1_MUCL30388 | cds-NP_010242.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:360834-362522:- | gene-YDL042C_MUCL39482 | rna-NM_001180101.1_MUCL39482 | cds-NP_010242.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:282751-284439:- | gene-YDL042C_MUCL42920 | rna-NM_001180101.1_MUCL42920 | cds-NP_010242.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:376680-378368:- | gene-YDL042C_NCIM3186 | rna-NM_001180101.1_NCIM3186 | cds-NP_010242.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:360715-362403:- | gene-YDL042C_NCYC1407 | rna-NM_001180101.1_NCYC1407 | cds-NP_010242.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:367889-369577:- | gene-YDL042C_PE2H3 | rna-NM_001180101.1_PE2H3 | cds-NP_010242.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:367891-369579:- | gene-YDL042C_PE2H4 | rna-NM_001180101.1_PE2H4 | cds-NP_010242.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:376757-378445:- | gene-YDL042C_S288C | rna-NM_001180101.1_S288C | cds-NP_010242.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:56483-58171:+ | gene-YDL042C_SA1 | rna-NM_001180101.1_SA1 | cds-NP_010242.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:377854-379542:- | gene-YDL042C_ThermosaccDry | rna-NM_001180101.1_ThermosaccDry | cds-NP_010242.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:380778-382466:- | gene-YDL042C_VR1 | rna-NM_001180101.1_VR1 | cds-NP_010242.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:375795-377483:- | gene-YDL042C_ZTW1 | rna-NM_001180101.1_ZTW1 | cds-NP_010242.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:378212-379914:- | gene-YDL042C_Sparadoxus | rna-NM_001180101.1_Sparadoxus | cds-NP_010242.1_Sparadoxus | 89.7 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |