Gene name: SIC1
Reference locus (S288C): YLR079W
Gene biotype: protein_coding
Description: Protein SIC1; Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
Top 10 interactors (score): CDC4 (0.999); CLB5 (0.999); CDC14 (0.999); CLB2 (0.999); CDC28 (0.998); CLB1 (0.99); CLB6 (0.988); CLB3 (0.987); CLN2 (0.986); CDC53 (0.985); SKP1 (0.982); HOG1 (0.98); IME2 (0.976); CKS1 (0.972); CLN1 (0.967); CDH1 (0.952); HRT1 (0.946); SWI5 (0.942); CLB4 (0.94); CDC34 (0.939)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:269291-270145:+ | gene-YLR079W_AKU4011 | rna-NM_001181966.1_AKU4011 | cds-NP_013180.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:232427-233281:+ | gene-YLR079W_BG1 | rna-NM_001181966.1_BG1 | cds-NP_013180.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:279200-280054:+ | gene-YLR079W_Bruggeman | rna-NM_001181966.1_Bruggeman | cds-NP_013180.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:279516-280370:+ | gene-YLR079W_CAT1 | rna-NM_001181966.1_CAT1 | cds-NP_013180.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:276405-277259:+ | gene-YLR079W_CBS1585 | rna-NM_001181966.1_CBS1585 | cds-NP_013180.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:267031-267885:+ | gene-YLR079W_CBS436 | rna-NM_001181966.1_CBS436 | cds-NP_013180.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:274847-275701:+ | gene-YLR079W_CBS6412 | rna-NM_001181966.1_CBS6412 | cds-NP_013180.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:276674-277528:+ | gene-YLR079W_CBS6413 | rna-NM_001181966.1_CBS6413 | cds-NP_013180.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:271837-272691:+ | gene-YLR079W_CENPK1137D | rna-NM_001181966.1_CENPK1137D | cds-NP_013180.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:268813-269667:+ | gene-YLR079W_EthanolRed | rna-NM_001181966.1_EthanolRed | cds-NP_013180.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:268689-269543:+ | gene-YLR079W_FaliES1 | rna-NM_001181966.1_FaliES1 | cds-NP_013180.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:43618-44475:+ | gene-YLR079W_JAY291 | rna-NM_001181966.1_JAY291 | cds-NP_013180.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:276566-277420:+ | gene-YLR079W_MUCL30387 | rna-NM_001181966.1_MUCL30387 | cds-NP_013180.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:284213-285067:+ | gene-YLR079W_MUCL30388 | rna-NM_001181966.1_MUCL30388 | cds-NP_013180.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:276923-277777:+ | gene-YLR079W_MUCL39482 | rna-NM_001181966.1_MUCL39482 | cds-NP_013180.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:276847-277701:+ | gene-YLR079W_MUCL42920 | rna-NM_001181966.1_MUCL42920 | cds-NP_013180.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:286794-287648:+ | gene-YLR079W_NCIM3186 | rna-NM_001181966.1_NCIM3186 | cds-NP_013180.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:268995-269849:+ | gene-YLR079W_NCYC1407 | rna-NM_001181966.1_NCYC1407 | cds-NP_013180.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:274856-275710:+ | gene-YLR079W_PE2H3 | rna-NM_001181966.1_PE2H3 | cds-NP_013180.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:274597-275451:+ | gene-YLR079W_PE2H4 | rna-NM_001181966.1_PE2H4 | cds-NP_013180.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:286820-287674:+ | gene-YLR079W_S288C | rna-NM_001181966.1_S288C | cds-NP_013180.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000033.1:86453-87307:- | gene-YLR079W_SA1 | rna-NM_001181966.1_SA1 | cds-NP_013180.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:268865-269719:+ | gene-YLR079W_ThermosaccDry | rna-NM_001181966.1_ThermosaccDry | cds-NP_013180.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:282551-283405:+ | gene-YLR079W_VR1 | rna-NM_001181966.1_VR1 | cds-NP_013180.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:268249-269103:+ | gene-YLR079W_ZTW1 | rna-NM_001181966.1_ZTW1 | cds-NP_013180.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:277118-277954:+ | gene-YLR079W_Sparadoxus | rna-NM_001181966.1_Sparadoxus | cds-NP_013180.1_Sparadoxus | 88.6 | 97.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |