Gene name: SHM2
Reference locus (S288C): YLR058C
Gene biotype: protein_coding
Description: Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; Belongs to the SHMT family
Top 10 interactors (score): GCV1 (0.999); GCV2 (0.999); MTD1 (0.999); ADE17 (0.999); ADE3 (0.998); GLY1 (0.997); GCV3 (0.996); AGX1 (0.996); ADE16 (0.992); SER2 (0.989); MIS1 (0.985); ADE13 (0.981); DFR1 (0.979); ADE8 (0.978); ADE4 (0.976); TRP5 (0.975); ADE1 (0.975); CDC21 (0.973); LPD1 (0.971); MET7 (0.97)
Homologues (species, bitscore): SHMT1 (Homo sapiens, 555.1); Shmt1 (Mus musculus, 566.2); shmt1 (Danio rerio, 570.9); shmt2 (Xenopus tropicalis, 556.2); CG3011 (Drosophila melanogaster, 541.6); mel-32 (Caenorhabditis elegans, 550.1); SHM1 (Arabidopsis thaliana, 568.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:240478-241887:- | gene-YLR058C_AKU4011 | rna-NM_001181945.1_AKU4011 | cds-NP_013159.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:203600-205009:- | gene-YLR058C_BG1 | rna-NM_001181945.1_BG1 | cds-NP_013159.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:250387-251796:- | gene-YLR058C_Bruggeman | rna-NM_001181945.1_Bruggeman | cds-NP_013159.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:250692-252101:- | gene-YLR058C_CAT1 | rna-NM_001181945.1_CAT1 | cds-NP_013159.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:247613-249022:- | gene-YLR058C_CBS1585 | rna-NM_001181945.1_CBS1585 | cds-NP_013159.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:238226-239635:- | gene-YLR058C_CBS436 | rna-NM_001181945.1_CBS436 | cds-NP_013159.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:246022-247431:- | gene-YLR058C_CBS6412 | rna-NM_001181945.1_CBS6412 | cds-NP_013159.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:247876-249285:- | gene-YLR058C_CBS6413 | rna-NM_001181945.1_CBS6413 | cds-NP_013159.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:237250-238659:- | gene-YLR058C_CENPK1137D | rna-NM_001181945.1_CENPK1137D | cds-NP_013159.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:239990-241399:- | gene-YLR058C_EthanolRed | rna-NM_001181945.1_EthanolRed | cds-NP_013159.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:239877-241286:- | gene-YLR058C_FaliES1 | rna-NM_001181945.1_FaliES1 | cds-NP_013159.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:14797-16206:- | gene-YLR058C_JAY291 | rna-NM_001181945.1_JAY291 | cds-NP_013159.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:247740-249149:- | gene-YLR058C_MUCL30387 | rna-NM_001181945.1_MUCL30387 | cds-NP_013159.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:255395-256804:- | gene-YLR058C_MUCL30388 | rna-NM_001181945.1_MUCL30388 | cds-NP_013159.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:248108-249517:- | gene-YLR058C_MUCL39482 | rna-NM_001181945.1_MUCL39482 | cds-NP_013159.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:248016-249425:- | gene-YLR058C_MUCL42920 | rna-NM_001181945.1_MUCL42920 | cds-NP_013159.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:257966-259375:- | gene-YLR058C_NCIM3186 | rna-NM_001181945.1_NCIM3186 | cds-NP_013159.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:240169-241578:- | gene-YLR058C_NCYC1407 | rna-NM_001181945.1_NCYC1407 | cds-NP_013159.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:246034-247443:- | gene-YLR058C_PE2H3 | rna-NM_001181945.1_PE2H3 | cds-NP_013159.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:245775-247184:- | gene-YLR058C_PE2H4 | rna-NM_001181945.1_PE2H4 | cds-NP_013159.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:257992-259401:- | gene-YLR058C_S288C | rna-NM_001181945.1_S288C | cds-NP_013159.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000046.1:83846-85255:- | gene-YLR058C_SA1 | rna-NM_001181945.1_SA1 | cds-NP_013159.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:240062-241471:- | gene-YLR058C_ThermosaccDry | rna-NM_001181945.1_ThermosaccDry | cds-NP_013159.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:253726-255135:- | gene-YLR058C_VR1 | rna-NM_001181945.1_VR1 | cds-NP_013159.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:239425-240834:- | gene-YLR058C_ZTW1 | rna-NM_001181945.1_ZTW1 | cds-NP_013159.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:248288-249697:- | gene-YLR058C_Sparadoxus | rna-NM_001181945.1_Sparadoxus | cds-NP_013159.1_Sparadoxus | 95.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |