Gene name: SGT2
Reference locus (S288C): YOR007C
Gene biotype: protein_coding
Description: Small glutamine-rich tetratricopeptide repeat-containing protein 2; Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
Top 10 interactors (score): GET4 (0.999); MDY2 (0.999); HSP104 (0.998); YBR137W (0.998); GET3 (0.998); YDJ1 (0.997); SSE1 (0.994); SSE2 (0.992); HSC82 (0.977); GET1 (0.971); SSA1 (0.969); VMA10 (0.964); VMA4 (0.963); VMA8 (0.962); URH1 (0.962); XDJ1 (0.92); CPR6 (0.911); SSA2 (0.905); HSP82 (0.904); SIS1 (0.891)
Homologues (species, bitscore): SGTA (Homo sapiens, 133.7); Sgta (Mus musculus, 127.1); sgta (Danio rerio, 110.2); sgta (Xenopus tropicalis, 138.3); Sgt (Drosophila melanogaster, 92.4); sgt-1 (Caenorhabditis elegans, 134.4); Hop1 (Arabidopsis thaliana, 100.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:323300-324340:- | gene-YOR007C_AKU4011 | rna-NM_001183426.1_AKU4011 | cds-NP_014649.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:138914-139954:- | gene-YOR007C_BG1 | rna-NM_001183426.1_BG1 | cds-NP_014649.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:326071-327111:- | gene-YOR007C_Bruggeman | rna-NM_001183426.1_Bruggeman | cds-NP_014649.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:324226-325266:- | gene-YOR007C_CAT1 | rna-NM_001183426.1_CAT1 | cds-NP_014649.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:317974-319014:- | gene-YOR007C_CBS1585 | rna-NM_001183426.1_CBS1585 | cds-NP_014649.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:322244-323284:- | gene-YOR007C_CBS436 | rna-NM_001183426.1_CBS436 | cds-NP_014649.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:317280-318320:- | gene-YOR007C_CBS6412 | rna-NM_001183426.1_CBS6412 | cds-NP_014649.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:324811-325851:- | gene-YOR007C_CBS6413 | rna-NM_001183426.1_CBS6413 | cds-NP_014649.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:338621-339661:- | gene-YOR007C_CENPK1137D | rna-NM_001183426.1_CENPK1137D | cds-NP_014649.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:320061-321101:- | gene-YOR007C_EthanolRed | rna-NM_001183426.1_EthanolRed | cds-NP_014649.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:323388-324428:- | gene-YOR007C_FaliES1 | rna-NM_001183426.1_FaliES1 | cds-NP_014649.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000015.1:4808-5848:+ | gene-YOR007C_JAY291 | rna-NM_001183426.1_JAY291 | cds-NP_014649.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:330285-331325:- | gene-YOR007C_MUCL30387 | rna-NM_001183426.1_MUCL30387 | cds-NP_014649.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:333721-334761:- | gene-YOR007C_MUCL30388 | rna-NM_001183426.1_MUCL30388 | cds-NP_014649.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:325457-326497:- | gene-YOR007C_MUCL39482 | rna-NM_001183426.1_MUCL39482 | cds-NP_014649.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:340311-341351:- | gene-YOR007C_MUCL42920 | rna-NM_001183426.1_MUCL42920 | cds-NP_014649.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:338827-339867:- | gene-YOR007C_NCIM3186 | rna-NM_001183426.1_NCIM3186 | cds-NP_014649.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:332142-333182:- | gene-YOR007C_NCYC1407 | rna-NM_001183426.1_NCYC1407 | cds-NP_014649.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:326838-327878:- | gene-YOR007C_PE2H3 | rna-NM_001183426.1_PE2H3 | cds-NP_014649.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:337217-338257:- | gene-YOR007C_PE2H4 | rna-NM_001183426.1_PE2H4 | cds-NP_014649.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:338938-339978:- | gene-YOR007C_S288C | rna-NM_001183426.1_S288C | cds-NP_014649.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:306905-307945:- | gene-YOR007C_SA1 | rna-NM_001183426.1_SA1 | cds-NP_014649.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:321959-322999:- | gene-YOR007C_ThermosaccDry | rna-NM_001183426.1_ThermosaccDry | cds-NP_014649.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:322793-323833:- | gene-YOR007C_VR1 | rna-NM_001183426.1_VR1 | cds-NP_014649.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:56623-57663:- | gene-YOR007C_ZTW1 | rna-NM_001183426.1_ZTW1 | cds-NP_014649.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:330430-331470:- | gene-YOR007C_Sparadoxus | rna-NM_001183426.1_Sparadoxus | cds-NP_014649.1_Sparadoxus | 90.8 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |