Gene name: SGS1
Reference locus (S288C): YMR190C
Gene biotype: protein_coding
Description: ATP-dependent helicase SGS1; RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant; Belongs to the helicase family. RecQ subfamily
Top 10 interactors (score): YKU80 (0.999); EXO1 (0.999); RFA1 (0.999); RAD1 (0.999); MEC1 (0.999); RAD9 (0.999); SRS2 (0.999); MLH1 (0.999); YKU70 (0.999); RAD57 (0.999); MUS81 (0.999); MPH1 (0.999); RAD52 (0.999); TOP3 (0.999); RAD51 (0.999); RMI1 (0.999); DNA2 (0.999); RRM3 (0.998); RAD53 (0.998); RAD27 (0.998)
Homologues (species, bitscore): BLM (Homo sapiens, 434.5); Blm (Mus musculus, 430.3); blm (Danio rerio, 449.1); blm (Xenopus tropicalis, 434.9); Blm (Drosophila melanogaster, 464.2); him-6 (Caenorhabditis elegans, 380.2); RECQ4A (Arabidopsis thaliana, 456.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:680847-685190:- | gene-YMR190C_AKU4011 | rna-NM_001182696.1_AKU4011 | cds-NP_013915.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:269392-273735:+ | gene-YMR190C_BG1 | rna-NM_001182696.1_BG1 | cds-NP_013915.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:625077-629420:- | gene-YMR190C_Bruggeman | rna-NM_001182696.1_Bruggeman | cds-NP_013915.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:628320-632663:- | gene-YMR190C_CAT1 | rna-NM_001182696.1_CAT1 | cds-NP_013915.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:613103-617446:- | gene-YMR190C_CBS1585 | rna-NM_001182696.1_CBS1585 | cds-NP_013915.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:617366-621709:- | gene-YMR190C_CBS436 | rna-NM_001182696.1_CBS436 | cds-NP_013915.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:724662-729005:- | gene-YMR190C_CBS6412 | rna-NM_001182696.1_CBS6412 | cds-NP_013915.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:612252-616595:- | gene-YMR190C_CBS6413 | rna-NM_001182696.1_CBS6413 | cds-NP_013915.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:635528-639907:- | gene-YMR190C_CENPK1137D | rna-NM_001182696.1_CENPK1137D | cds-NP_013915.1_CENPK1137D | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:673292-677635:- | gene-YMR190C_EthanolRed | rna-NM_001182696.1_EthanolRed | cds-NP_013915.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:618948-623291:- | gene-YMR190C_FaliES1 | rna-NM_001182696.1_FaliES1 | cds-NP_013915.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:162716-167059:+ | gene-YMR190C_JAY291 | rna-NM_001182696.1_JAY291 | cds-NP_013915.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:618623-622966:- | gene-YMR190C_MUCL30387 | rna-NM_001182696.1_MUCL30387 | cds-NP_013915.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:625403-629746:- | gene-YMR190C_MUCL30388 | rna-NM_001182696.1_MUCL30388 | cds-NP_013915.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:614175-618518:- | gene-YMR190C_MUCL39482 | rna-NM_001182696.1_MUCL39482 | cds-NP_013915.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:621522-625865:- | gene-YMR190C_MUCL42920 | rna-NM_001182696.1_MUCL42920 | cds-NP_013915.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:640869-645212:- | gene-YMR190C_NCIM3186 | rna-NM_001182696.1_NCIM3186 | cds-NP_013915.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:613827-618170:- | gene-YMR190C_NCYC1407 | rna-NM_001182696.1_NCYC1407 | cds-NP_013915.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:623710-628053:- | gene-YMR190C_PE2H3 | rna-NM_001182696.1_PE2H3 | cds-NP_013915.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:624696-629039:- | gene-YMR190C_PE2H4 | rna-NM_001182696.1_PE2H4 | cds-NP_013915.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:640915-645258:- | gene-YMR190C_S288C | rna-NM_001182696.1_S288C | cds-NP_013915.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:162842-167185:+ | gene-YMR190C_SA1 | rna-NM_001182696.1_SA1 | cds-NP_013915.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:615074-619417:- | gene-YMR190C_ThermosaccDry | rna-NM_001182696.1_ThermosaccDry | cds-NP_013915.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:628243-632586:- | gene-YMR190C_VR1 | rna-NM_001182696.1_VR1 | cds-NP_013915.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:30862-35205:- | gene-YMR190C_ZTW1 | rna-NM_001182696.1_ZTW1 | cds-NP_013915.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:632968-637311:- | gene-YMR190C_Sparadoxus | rna-NM_001182696.1_Sparadoxus | cds-NP_013915.1_Sparadoxus | 89.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |