Gene name: SET2
Reference locus (S288C): YJL168C
Gene biotype: protein_coding
Description: Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia
Top 10 interactors (score): DOT1 (0.999); RPO21 (0.999); HHT1 (0.998); HHT2 (0.997); SPT5 (0.996); SPT6 (0.996); BRE1 (0.993); HHF1 (0.993); RPD3 (0.992); HTZ1 (0.992); EAF3 (0.99); SPN1 (0.989); CHD1 (0.988); RCO1 (0.987); SWD3 (0.982); SET1 (0.979); SPT16 (0.976); RPB2 (0.974); RPB3 (0.971); SGV1 (0.966)
Homologues (species, bitscore): SETD2 (Homo sapiens, 201.1); Setd2 (Mus musculus, 200.3); setd2 (Danio rerio, 208.4); whsc1 (Xenopus tropicalis, 171.8); Set2 (Drosophila melanogaster, 203.8); met-1 (Caenorhabditis elegans, 159.1); EFS (Arabidopsis thaliana, 179.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:90610-92811:- | gene-YJL168C_AKU4011 | rna-NM_001181601.2_AKU4011 | cds-NP_012367.2_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000186.1:2656-4857:- | gene-YJL168C_BG1 | rna-NM_001181601.2_BG1 | cds-NP_012367.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:102441-104642:- | gene-YJL168C_Bruggeman | rna-NM_001181601.2_Bruggeman | cds-NP_012367.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:105912-108113:- | gene-YJL168C_CAT1 | rna-NM_001181601.2_CAT1 | cds-NP_012367.2_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:96245-98446:- | gene-YJL168C_CBS1585 | rna-NM_001181601.2_CBS1585 | cds-NP_012367.2_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:121009-123210:- | gene-YJL168C_CBS436 | rna-NM_001181601.2_CBS436 | cds-NP_012367.2_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:92727-94928:- | gene-YJL168C_CBS6412 | rna-NM_001181601.2_CBS6412 | cds-NP_012367.2_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:93720-95921:- | gene-YJL168C_CBS6413 | rna-NM_001181601.2_CBS6413 | cds-NP_012367.2_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:84691-86892:- | gene-YJL168C_CENPK1137D | rna-NM_001181601.2_CENPK1137D | cds-NP_012367.2_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:94906-97107:- | gene-YJL168C_EthanolRed | rna-NM_001181601.2_EthanolRed | cds-NP_012367.2_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:100183-102384:- | gene-YJL168C_FaliES1 | rna-NM_001181601.2_FaliES1 | cds-NP_012367.2_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000164.1:16340-18541:+ | gene-YJL168C_JAY291 | rna-NM_001181601.2_JAY291 | cds-NP_012367.2_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:104169-106370:- | gene-YJL168C_MUCL30387 | rna-NM_001181601.2_MUCL30387 | cds-NP_012367.2_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:100731-102932:- | gene-YJL168C_MUCL30388 | rna-NM_001181601.2_MUCL30388 | cds-NP_012367.2_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:94987-97188:- | gene-YJL168C_MUCL39482 | rna-NM_001181601.2_MUCL39482 | cds-NP_012367.2_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:99597-101798:- | gene-YJL168C_MUCL42920 | rna-NM_001181601.2_MUCL42920 | cds-NP_012367.2_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:102206-104407:- | gene-YJL168C_NCIM3186 | rna-NM_001181601.2_NCIM3186 | cds-NP_012367.2_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:93598-95799:- | gene-YJL168C_NCYC1407 | rna-NM_001181601.2_NCYC1407 | cds-NP_012367.2_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:106314-108515:- | gene-YJL168C_PE2H3 | rna-NM_001181601.2_PE2H3 | cds-NP_012367.2_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:105953-108154:- | gene-YJL168C_PE2H4 | rna-NM_001181601.2_PE2H4 | cds-NP_012367.2_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:102227-104428:- | gene-YJL168C_S288C | rna-NM_001181601.2_S288C | cds-NP_012367.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:49117-51318:+ | gene-YJL168C_SA1 | rna-NM_001181601.2_SA1 | cds-NP_012367.2_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:93376-95577:- | gene-YJL168C_ThermosaccDry | rna-NM_001181601.2_ThermosaccDry | cds-NP_012367.2_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:100264-102465:- | gene-YJL168C_VR1 | rna-NM_001181601.2_VR1 | cds-NP_012367.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:80957-83158:- | gene-YJL168C_ZTW1 | rna-NM_001181601.2_ZTW1 | cds-NP_012367.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:105411-107612:- | gene-YJL168C_Sparadoxus | rna-NM_001181601.2_Sparadoxus | cds-NP_012367.2_Sparadoxus | 91.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |