Gene name: SET1
Reference locus (S288C): YHR119W
Gene biotype: protein_coding
Description: Histone-lysine N-methyltransferase, H3 lysine-4 specific; Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain; Belongs to the class V-like SAM-binding methyltransf [...]
Top 10 interactors (score): BRE2 (0.999); SWD2 (0.999); SDC1 (0.999); SPP1 (0.999); SWD3 (0.999); SWD1 (0.999); DOT1 (0.999); SHG1 (0.998); HHT2 (0.997); HHT1 (0.997); JHD2 (0.993); SWR1 (0.991); CHD1 (0.989); BRE1 (0.988); SET4 (0.983); SIR2 (0.979); SET2 (0.979); SET3 (0.974); RPO21 (0.973); HTZ1 (0.972)
Homologues (species, bitscore): SETD1A (Homo sapiens, 218.4); Setd1a (Mus musculus, 218.4); setd1a (Danio rerio, 218.0); setd1a (Xenopus tropicalis, 215.7); Set1 (Drosophila melanogaster, 206.8); set-2 (Caenorhabditis elegans, 197.2); SDG25 (Arabidopsis thaliana, 194.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:332970-336212:+ | gene-YHR119W_AKU4011 | rna-NM_001179249.1_AKU4011 | cds-NP_011987.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:181661-184903:- | gene-YHR119W_BG1 | rna-NM_001179249.1_BG1 | cds-NP_011987.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:340260-343502:+ | gene-YHR119W_Bruggeman | rna-NM_001179249.1_Bruggeman | cds-NP_011987.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:335398-338640:+ | gene-YHR119W_CAT1 | rna-NM_001179249.1_CAT1 | cds-NP_011987.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:331994-335236:+ | gene-YHR119W_CBS1585 | rna-NM_001179249.1_CBS1585 | cds-NP_011987.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:329352-332594:+ | gene-YHR119W_CBS436 | rna-NM_001179249.1_CBS436 | cds-NP_011987.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:333432-336674:+ | gene-YHR119W_CBS6412 | rna-NM_001179249.1_CBS6412 | cds-NP_011987.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:333021-336263:+ | gene-YHR119W_CBS6413 | rna-NM_001179249.1_CBS6413 | cds-NP_011987.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:339217-342459:+ | gene-YHR119W_CENPK1137D | rna-NM_001179249.1_CENPK1137D | cds-NP_011987.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:391875-395117:+ | gene-YHR119W_EthanolRed | rna-NM_001179249.1_EthanolRed | cds-NP_011987.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:333363-336605:+ | gene-YHR119W_FaliES1 | rna-NM_001179249.1_FaliES1 | cds-NP_011987.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000139.1:5979-9221:+ | gene-YHR119W_JAY291 | rna-NM_001179249.1_JAY291 | cds-NP_011987.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:339990-343232:+ | gene-YHR119W_MUCL30387 | rna-NM_001179249.1_MUCL30387 | cds-NP_011987.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:339637-342879:+ | gene-YHR119W_MUCL30388 | rna-NM_001179249.1_MUCL30388 | cds-NP_011987.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:332333-335575:+ | gene-YHR119W_MUCL39482 | rna-NM_001179249.1_MUCL39482 | cds-NP_011987.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:338573-341815:+ | gene-YHR119W_MUCL42920 | rna-NM_001179249.1_MUCL42920 | cds-NP_011987.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:345925-349167:+ | gene-YHR119W_NCIM3186 | rna-NM_001179249.1_NCIM3186 | cds-NP_011987.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:334543-337785:+ | gene-YHR119W_NCYC1407 | rna-NM_001179249.1_NCYC1407 | cds-NP_011987.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:333995-337237:+ | gene-YHR119W_PE2H3 | rna-NM_001179249.1_PE2H3 | cds-NP_011987.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:341422-344664:+ | gene-YHR119W_PE2H4 | rna-NM_001179249.1_PE2H4 | cds-NP_011987.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:346043-349285:+ | gene-YHR119W_S288C | rna-NM_001179249.1_S288C | cds-NP_011987.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:9685-12927:- | gene-YHR119W_SA1 | rna-NM_001179249.1_SA1 | cds-NP_011987.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:334446-337688:+ | gene-YHR119W_ThermosaccDry | rna-NM_001179249.1_ThermosaccDry | cds-NP_011987.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:342067-345309:+ | gene-YHR119W_VR1 | rna-NM_001179249.1_VR1 | cds-NP_011987.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:325457-328699:+ | gene-YHR119W_ZTW1 | rna-NM_001179249.1_ZTW1 | cds-NP_011987.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:331120-334365:+ | gene-YHR119W_Sparadoxus | rna-NM_001179249.1_Sparadoxus | cds-NP_011987.1_Sparadoxus | 89.2 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |