Gene name: SER33
Reference locus (S288C): YIL074C
Gene biotype: protein_coding
Description: D-3-phosphoglycerate dehydrogenase 2; 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication
Top 10 interactors (score): SER3 (0.999); SER1 (0.999); TDA10 (0.946); MET3 (0.928); GPM1 (0.924); SER2 (0.921); BNA3 (0.918); GCV1 (0.91); GPM3 (0.907); GPM2 (0.907); ADE12 (0.893); MET5 (0.893); FUM1 (0.882); UGA1 (0.857); ALT2 (0.856); PRM15 (0.852); YNK1 (0.845); TPI1 (0.84); YFR006W (0.84); MET10 (0.826)
Homologues (species, bitscore): PHGDH (Homo sapiens, 191.4); Phgdh (Mus musculus, 193.4); phgdh (Danio rerio, 176.8); phgdh (Xenopus tropicalis, 173.7); CG6287 (Drosophila melanogaster, 177.6); C31C9.2 (Caenorhabditis elegans, 167.5); EDA9 (Arabidopsis thaliana, 171.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:217749-219158:- | gene-YIL074C_AKU4011 | rna-NM_001179424.1_AKU4011 | cds-NP_012191.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000164.1:79682-81091:- | gene-YIL074C_BG1 | rna-NM_001179424.1_BG1 | cds-NP_012191.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:223165-224574:- | gene-YIL074C_Bruggeman | rna-NM_001179424.1_Bruggeman | cds-NP_012191.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:213444-214853:- | gene-YIL074C_CAT1 | rna-NM_001179424.1_CAT1 | cds-NP_012191.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:217320-218729:- | gene-YIL074C_CBS1585 | rna-NM_001179424.1_CBS1585 | cds-NP_012191.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:213372-214781:- | gene-YIL074C_CBS436 | rna-NM_001179424.1_CBS436 | cds-NP_012191.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:214697-216106:- | gene-YIL074C_CBS6412 | rna-NM_001179424.1_CBS6412 | cds-NP_012191.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:209240-210649:- | gene-YIL074C_CBS6413 | rna-NM_001179424.1_CBS6413 | cds-NP_012191.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:212785-214194:- | gene-YIL074C_CENPK1137D | rna-NM_001179424.1_CENPK1137D | cds-NP_012191.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:202044-203453:- | gene-YIL074C_EthanolRed | rna-NM_001179424.1_EthanolRed | cds-NP_012191.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:218952-220361:- | gene-YIL074C_FaliES1 | rna-NM_001179424.1_FaliES1 | cds-NP_012191.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000025.1:9149-10558:+ | gene-YIL074C_JAY291 | rna-NM_001179424.1_JAY291 | cds-NP_012191.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:221382-222791:- | gene-YIL074C_MUCL30387 | rna-NM_001179424.1_MUCL30387 | cds-NP_012191.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:217991-219400:- | gene-YIL074C_MUCL30388 | rna-NM_001179424.1_MUCL30388 | cds-NP_012191.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:218167-219576:- | gene-YIL074C_MUCL39482 | rna-NM_001179424.1_MUCL39482 | cds-NP_012191.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:221529-222938:- | gene-YIL074C_MUCL42920 | rna-NM_001179424.1_MUCL42920 | cds-NP_012191.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:221081-222490:- | gene-YIL074C_NCIM3186 | rna-NM_001179424.1_NCIM3186 | cds-NP_012191.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:222444-223853:- | gene-YIL074C_NCYC1407 | rna-NM_001179424.1_NCYC1407 | cds-NP_012191.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:216426-217835:- | gene-YIL074C_PE2H3 | rna-NM_001179424.1_PE2H3 | cds-NP_012191.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:211143-212552:- | gene-YIL074C_PE2H4 | rna-NM_001179424.1_PE2H4 | cds-NP_012191.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:221081-222490:- | gene-YIL074C_S288C | rna-NM_001179424.1_S288C | cds-NP_012191.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000031.1:103344-104753:+ | gene-YIL074C_SA1 | rna-NM_001179424.1_SA1 | cds-NP_012191.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:217616-219025:- | gene-YIL074C_ThermosaccDry | rna-NM_001179424.1_ThermosaccDry | cds-NP_012191.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:215301-216710:- | gene-YIL074C_VR1 | rna-NM_001179424.1_VR1 | cds-NP_012191.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:191878-193287:- | gene-YIL074C_ZTW1 | rna-NM_001179424.1_ZTW1 | cds-NP_012191.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:216000-217409:- | gene-YIL074C_Sparadoxus | rna-NM_001179424.1_Sparadoxus | cds-NP_012191.1_Sparadoxus | 89.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |