Gene name: SER3
Reference locus (S288C): YER081W
Gene biotype: protein_coding
Description: D-3-phosphoglycerate dehydrogenase 1; 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER3 has a paralog, SER33, that arose from the whole genome duplication
Top 10 interactors (score): SER33 (0.999); SER1 (0.999); ADE12 (0.93); GPM1 (0.93); SER2 (0.92); GPM2 (0.917); GPM3 (0.907); TDA10 (0.901); GCV1 (0.882); FUM1 (0.881); SPT6 (0.874); ALT2 (0.869); UGA1 (0.857); PRM15 (0.846); YNK1 (0.845); TPI1 (0.84); YFR006W (0.84); SNF11 (0.79); ALT1 (0.79); IME4 (0.779)
Homologues (species, bitscore): PHGDH (Homo sapiens, 191.4); Phgdh (Mus musculus, 193.7); phgdh (Danio rerio, 193.0); phgdh (Xenopus tropicalis, 173.7); CG6287 (Drosophila melanogaster, 189.9); C31C9.2 (Caenorhabditis elegans, 170.6); PGDH (Arabidopsis thaliana, 171.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:316464-317873:+ | gene-YER081W_AKU4011 | rna-NM_001178972.3_AKU4011 | cds-NP_011004.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:107930-109339:- | gene-YER081W_BG1 | rna-NM_001178972.3_BG1 | cds-NP_011004.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:326057-327466:+ | gene-YER081W_Bruggeman | rna-NM_001178972.3_Bruggeman | cds-NP_011004.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:320409-321818:+ | gene-YER081W_CAT1 | rna-NM_001178972.3_CAT1 | cds-NP_011004.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:316329-317738:+ | gene-YER081W_CBS1585 | rna-NM_001178972.3_CBS1585 | cds-NP_011004.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:318468-319877:+ | gene-YER081W_CBS436 | rna-NM_001178972.3_CBS436 | cds-NP_011004.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:315786-317195:+ | gene-YER081W_CBS6412 | rna-NM_001178972.3_CBS6412 | cds-NP_011004.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:321776-323185:+ | gene-YER081W_CBS6413 | rna-NM_001178972.3_CBS6413 | cds-NP_011004.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:320597-322006:+ | gene-YER081W_CENPK1137D | rna-NM_001178972.3_CENPK1137D | cds-NP_011004.3_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:316808-318217:+ | gene-YER081W_EthanolRed | rna-NM_001178972.3_EthanolRed | cds-NP_011004.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:317253-318662:+ | gene-YER081W_FaliES1 | rna-NM_001178972.3_FaliES1 | cds-NP_011004.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000153.1:32309-33718:+ | gene-YER081W_JAY291 | rna-NM_001178972.3_JAY291 | cds-NP_011004.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:321452-322861:+ | gene-YER081W_MUCL30387 | rna-NM_001178972.3_MUCL30387 | cds-NP_011004.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:317123-318532:+ | gene-YER081W_MUCL30388 | rna-NM_001178972.3_MUCL30388 | cds-NP_011004.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:315353-316762:+ | gene-YER081W_MUCL39482 | rna-NM_001178972.3_MUCL39482 | cds-NP_011004.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:322593-324002:+ | gene-YER081W_MUCL42920 | rna-NM_001178972.3_MUCL42920 | cds-NP_011004.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:322685-324094:+ | gene-YER081W_NCIM3186 | rna-NM_001178972.3_NCIM3186 | cds-NP_011004.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:320417-321826:+ | gene-YER081W_NCYC1407 | rna-NM_001178972.3_NCYC1407 | cds-NP_011004.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:331063-332472:+ | gene-YER081W_PE2H3 | rna-NM_001178972.3_PE2H3 | cds-NP_011004.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:321004-322413:+ | gene-YER081W_PE2H4 | rna-NM_001178972.3_PE2H4 | cds-NP_011004.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:322686-324095:+ | gene-YER081W_S288C | rna-NM_001178972.3_S288C | cds-NP_011004.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:32313-33722:+ | gene-YER081W_SA1 | rna-NM_001178972.3_SA1 | cds-NP_011004.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:318050-319459:+ | gene-YER081W_ThermosaccDry | rna-NM_001178972.3_ThermosaccDry | cds-NP_011004.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:318743-320152:+ | gene-YER081W_VR1 | rna-NM_001178972.3_VR1 | cds-NP_011004.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:315209-316618:+ | gene-YER081W_ZTW1 | rna-NM_001178972.3_ZTW1 | cds-NP_011004.3_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:318586-319995:+ | gene-YER081W_Sparadoxus | rna-NM_001178972.3_Sparadoxus | cds-NP_011004.3_Sparadoxus | 92.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |