Gene name: SEN1
Reference locus (S288C): YLR430W
Gene biotype: protein_coding
Description: Helicase SEN1; ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS
Top 10 interactors (score): NAB3 (0.999); NRD1 (0.999); RPO21 (0.996); RNT1 (0.992); RAT1 (0.991); RRP6 (0.976); RAD2 (0.974); PCF11 (0.973); SPT5 (0.948); SSU72 (0.942); CBC2 (0.94); GLC7 (0.935); AIR2 (0.93); SEC16 (0.929); SCC2 (0.923); AIR1 (0.917); SPT4 (0.915); SWD2 (0.914); RAD27 (0.913); RTT103 (0.912)
Homologues (species, bitscore): SETX (Homo sapiens, 261.5); Setx (Mus musculus, 253.4); setx (Danio rerio, 266.2); setx (Xenopus tropicalis, 274.2); Upf1 (Drosophila melanogaster, 213.4); smg-2 (Caenorhabditis elegans, 192.2); AT1G16800 (Arabidopsis thaliana, 327.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:931693-938394:+ | gene-YLR430W_AKU4011 | rna-NM_001182318.3_AKU4011 | cds-NP_013534.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:164180-170875:+ | gene-YLR430W_BG1 | rna-NM_001182318.3_BG1 | cds-NP_013534.3_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:969996-976697:+ | gene-YLR430W_Bruggeman | rna-NM_001182318.3_Bruggeman | cds-NP_013534.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:966016-972711:+ | gene-YLR430W_CAT1 | rna-NM_001182318.3_CAT1 | cds-NP_013534.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:967290-973991:+ | gene-YLR430W_CBS1585 | rna-NM_001182318.3_CBS1585 | cds-NP_013534.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:956631-963326:+ | gene-YLR430W_CBS436 | rna-NM_001182318.3_CBS436 | cds-NP_013534.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:1003330-1010031:+ | gene-YLR430W_CBS6412 | rna-NM_001182318.3_CBS6412 | cds-NP_013534.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:968072-974776:+ | gene-YLR430W_CBS6413 | rna-NM_001182318.3_CBS6413 | cds-NP_013534.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:978056-984751:+ | gene-YLR430W_CENPK1137D | rna-NM_001182318.3_CENPK1137D | cds-NP_013534.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:924720-931421:+ | gene-YLR430W_EthanolRed | rna-NM_001182318.3_EthanolRed | cds-NP_013534.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:959991-966692:+ | gene-YLR430W_FaliES1 | rna-NM_001182318.3_FaliES1 | cds-NP_013534.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000194.1:52002-58697:- | gene-YLR430W_JAY291 | rna-NM_001182318.3_JAY291 | cds-NP_013534.3_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:968857-975558:+ | gene-YLR430W_MUCL30387 | rna-NM_001182318.3_MUCL30387 | cds-NP_013534.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:976215-982916:+ | gene-YLR430W_MUCL30388 | rna-NM_001182318.3_MUCL30388 | cds-NP_013534.3_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:968510-975211:+ | gene-YLR430W_MUCL39482 | rna-NM_001182318.3_MUCL39482 | cds-NP_013534.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:969006-975707:+ | gene-YLR430W_MUCL42920 | rna-NM_001182318.3_MUCL42920 | cds-NP_013534.3_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:993408-1000103:+ | gene-YLR430W_NCIM3186 | rna-NM_001182318.3_NCIM3186 | cds-NP_013534.3_NCIM3186 | 95.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:977689-984390:+ | gene-YLR430W_NCYC1407 | rna-NM_001182318.3_NCYC1407 | cds-NP_013534.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:964390-971085:+ | gene-YLR430W_PE2H3 | rna-NM_001182318.3_PE2H3 | cds-NP_013534.3_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:964134-970829:+ | gene-YLR430W_PE2H4 | rna-NM_001182318.3_PE2H4 | cds-NP_013534.3_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:993434-1000129:+ | gene-YLR430W_S288C | rna-NM_001182318.3_S288C | cds-NP_013534.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:59832-66527:- | gene-YLR430W_SA1 | rna-NM_001182318.3_SA1 | cds-NP_013534.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:963070-969771:+ | gene-YLR430W_ThermosaccDry | rna-NM_001182318.3_ThermosaccDry | cds-NP_013534.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:969495-976190:+ | gene-YLR430W_VR1 | rna-NM_001182318.3_VR1 | cds-NP_013534.3_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:293344-300045:+ | gene-YLR430W_ZTW1 | rna-NM_001182318.3_ZTW1 | cds-NP_013534.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:942487-949188:+ | gene-YLR430W_Sparadoxus | rna-NM_001182318.3_Sparadoxus | cds-NP_013534.3_Sparadoxus | 90.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |