Gene name: SEM1
Reference locus (S288C): YDR363W-A
Gene biotype: protein_coding
Description: 26S proteasome complex subunit SEM1; 19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): RPN1 (0.999); RPT2 (0.999); RPN5 (0.999); RPN9 (0.999); RPN8 (0.999); RPT5 (0.999); RPN7 (0.999); RPT3 (0.999); RPT4 (0.999); RPT6 (0.999); RPN13 (0.999); RPN3 (0.999); RPT1 (0.999); THP1 (0.999); RPN10 (0.999); RPN11 (0.999); RPN6 (0.999); RPN2 (0.999); RPN12 (0.999); PRE9 (0.998)
Homologues (species, bitscore): Shfm1 (Mus musculus, 55.5); shfm1 (Danio rerio, 53.1); shfm1 (Xenopus tropicalis, 55.1); Sem1 (Drosophila melanogaster, 54.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1148191-1148460:+ | gene-YDR363W-A_AKU4011 | rna-NM_001184328.3_AKU4011 | cds-NP_010651.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:26742-27011:+ | gene-YDR363W-A_BG1 | rna-NM_001184328.3_BG1 | cds-NP_010651.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1178844-1179113:+ | gene-YDR363W-A_Bruggeman | rna-NM_001184328.3_Bruggeman | cds-NP_010651.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1157436-1157705:+ | gene-YDR363W-A_CAT1 | rna-NM_001184328.3_CAT1 | cds-NP_010651.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1142908-1143177:+ | gene-YDR363W-A_CBS1585 | rna-NM_001184328.3_CBS1585 | cds-NP_010651.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1161492-1161761:+ | gene-YDR363W-A_CBS436 | rna-NM_001184328.3_CBS436 | cds-NP_010651.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1139168-1139437:+ | gene-YDR363W-A_CBS6412 | rna-NM_001184328.3_CBS6412 | cds-NP_010651.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1161058-1161327:+ | gene-YDR363W-A_CBS6413 | rna-NM_001184328.3_CBS6413 | cds-NP_010651.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1200773-1201042:+ | gene-YDR363W-A_CENPK1137D | rna-NM_001184328.3_CENPK1137D | cds-NP_010651.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1152596-1152865:+ | gene-YDR363W-A_EthanolRed | rna-NM_001184328.3_EthanolRed | cds-NP_010651.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1155879-1156148:+ | gene-YDR363W-A_FaliES1 | rna-NM_001184328.3_FaliES1 | cds-NP_010651.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000057.1:34926-35195:- | gene-YDR363W-A_JAY291 | rna-NM_001184328.3_JAY291 | cds-NP_010651.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1162144-1162413:+ | gene-YDR363W-A_MUCL30387 | rna-NM_001184328.3_MUCL30387 | cds-NP_010651.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1144749-1145018:+ | gene-YDR363W-A_MUCL30388 | rna-NM_001184328.3_MUCL30388 | cds-NP_010651.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1134442-1134711:+ | gene-YDR363W-A_MUCL39482 | rna-NM_001184328.3_MUCL39482 | cds-NP_010651.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1076876-1077145:+ | gene-YDR363W-A_MUCL42920 | rna-NM_001184328.3_MUCL42920 | cds-NP_010651.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1202051-1202320:+ | gene-YDR363W-A_NCIM3186 | rna-NM_001184328.3_NCIM3186 | cds-NP_010651.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1148113-1148382:+ | gene-YDR363W-A_NCYC1407 | rna-NM_001184328.3_NCYC1407 | cds-NP_010651.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1158545-1158814:+ | gene-YDR363W-A_PE2H3 | rna-NM_001184328.3_PE2H3 | cds-NP_010651.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1164130-1164399:+ | gene-YDR363W-A_PE2H4 | rna-NM_001184328.3_PE2H4 | cds-NP_010651.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1202128-1202397:+ | gene-YDR363W-A_S288C | rna-NM_001184328.3_S288C | cds-NP_010651.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000072.1:26823-27092:+ | gene-YDR363W-A_SA1 | rna-NM_001184328.3_SA1 | cds-NP_010651.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1160160-1160429:+ | gene-YDR363W-A_ThermosaccDry | rna-NM_001184328.3_ThermosaccDry | cds-NP_010651.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:587509-587778:+ | gene-YDR363W-A_VR1 | rna-NM_001184328.3_VR1 | cds-NP_010651.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:202991-203260:+ | gene-YDR363W-A_ZTW1 | rna-NM_001184328.3_ZTW1 | cds-NP_010651.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1154714-1154983:+ | gene-YDR363W-A_Sparadoxus | rna-NM_001184328.3_Sparadoxus | cds-NP_010651.3_Sparadoxus | 93.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |