Gene name: SED4
Reference locus (S288C): YCR067C
Gene biotype: protein_coding
Description: Putative guanine nucleotide-exchange factor SED4; Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication
Top 10 interactors (score): SAR1 (0.995); SEC16 (0.952); SEC13 (0.951); SEC23 (0.924); SEY1 (0.918); SEC31 (0.918); RER1 (0.888); SEC24 (0.883); SEC12 (0.868); ERD2 (0.856); SFB3 (0.791); SFB2 (0.748); SEC63 (0.741); SEC66 (0.711); SEC20 (0.693); SEC22 (0.692); YOS1 (0.652); YOS9 (0.636); BET3 (0.616); SEC18 (0.615)
Homologues (species, bitscore): MUC5AC (Homo sapiens, 119.4); Zan (Mus musculus, 73.6); dp (Drosophila melanogaster, 81.6); MFB16.9 (Arabidopsis thaliana, 53.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:227594-230836:- | gene-YCR067C_AKU4011 | rna-NM_001178778.1_AKU4011 | cds-NP_009993.1_AKU4011 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000067.1:86315-89512:- | gene-YCR067C_BG1 | rna-NM_001178778.1_BG1 | cds-NP_009993.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:223552-227049:- | gene-YCR067C_Bruggeman | rna-NM_001178778.1_Bruggeman | cds-NP_009993.1_Bruggeman | 90.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:234920-238117:- | gene-YCR067C_CAT1 | rna-NM_001178778.1_CAT1 | cds-NP_009993.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:222373-225615:- | gene-YCR067C_CBS1585 | rna-NM_001178778.1_CBS1585 | cds-NP_009993.1_CBS1585 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:234257-237454:- | gene-YCR067C_CBS436 | rna-NM_001178778.1_CBS436 | cds-NP_009993.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:214113-217355:- | gene-YCR067C_CBS6412 | rna-NM_001178778.1_CBS6412 | cds-NP_009993.1_CBS6412 | 97.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:228491-231703:- | gene-YCR067C_CBS6413 | rna-NM_001178778.1_CBS6413 | cds-NP_009993.1_CBS6413 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:232316-235570:- | gene-YCR067C_CENPK1137D | rna-NM_001178778.1_CENPK1137D | cds-NP_009993.1_CENPK1137D | 97.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:223558-226809:- | gene-YCR067C_EthanolRed | rna-NM_001178778.1_EthanolRed | cds-NP_009993.1_EthanolRed | 97.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:228723-231971:- | gene-YCR067C_FaliES1 | rna-NM_001178778.1_FaliES1 | cds-NP_009993.1_FaliES1 | 97.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000323.1:56749-59946:+ | gene-YCR067C_JAY291 | rna-NM_001178778.1_JAY291 | cds-NP_009993.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:220524-223772:- | gene-YCR067C_MUCL30387 | rna-NM_001178778.1_MUCL30387 | cds-NP_009993.1_MUCL30387 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:220848-224045:- | gene-YCR067C_MUCL30388 | rna-NM_001178778.1_MUCL30388 | cds-NP_009993.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:228946-232188:- | gene-YCR067C_MUCL39482 | rna-NM_001178778.1_MUCL39482 | cds-NP_009993.1_MUCL39482 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:225383-228625:- | gene-YCR067C_MUCL42920 | rna-NM_001178778.1_MUCL42920 | cds-NP_009993.1_MUCL42920 | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:232757-235954:- | gene-YCR067C_NCIM3186 | rna-NM_001178778.1_NCIM3186 | cds-NP_009993.1_NCIM3186 | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:229805-233047:- | gene-YCR067C_NCYC1407 | rna-NM_001178778.1_NCYC1407 | cds-NP_009993.1_NCYC1407 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:244440-247637:- | gene-YCR067C_PE2H3 | rna-NM_001178778.1_PE2H3 | cds-NP_009993.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:232991-236188:- | gene-YCR067C_PE2H4 | rna-NM_001178778.1_PE2H4 | cds-NP_009993.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:233125-236322:- | gene-YCR067C_S288C | rna-NM_001178778.1_S288C | cds-NP_009993.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000044.1:33018-36203:- | gene-YCR067C_SA1 | rna-NM_001178778.1_SA1 | cds-NP_009993.1_SA1 | 97.3 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:228707-231898:- | gene-YCR067C_ThermosaccDry | rna-NM_001178778.1_ThermosaccDry | cds-NP_009993.1_ThermosaccDry | 97.2 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:239976-243173:- | gene-YCR067C_VR1 | rna-NM_001178778.1_VR1 | cds-NP_009993.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:226521-229772:- | gene-YCR067C_ZTW1 | rna-NM_001178778.1_ZTW1 | cds-NP_009993.1_ZTW1 | 97.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:260719-263931:- | gene-YCR067C_Sparadoxus | rna-NM_001178778.1_Sparadoxus | cds-NP_009993.1_Sparadoxus | 73.7 | 93.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |