Gene name: SEC61
Reference locus (S288C): YLR378C
Gene biotype: protein_coding
Description: Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER
Top 10 interactors (score): SBH1 (0.999); SEC62 (0.999); KAR2 (0.999); SBH2 (0.999); SSS1 (0.999); SSH1 (0.999); SEC63 (0.999); SEC66 (0.998); SEC72 (0.998); WBP1 (0.997); STT3 (0.997); OST3 (0.996); CNE1 (0.996); SEC23 (0.994); PDI1 (0.993); HRD1 (0.993); SWP1 (0.992); DER1 (0.992); ERV29 (0.989); LHS1 (0.988)
Homologues (species, bitscore): SEC61A1 (Homo sapiens, 548.1); Sec61a1 (Mus musculus, 548.1); sec61a1 (Danio rerio, 550.4); sec61a1 (Xenopus tropicalis, 543.9); Sec61alpha (Drosophila melanogaster, 548.1); sec-61 (Caenorhabditis elegans, 540.4); AT1G78720 (Arabidopsis thaliana, 527.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:825271-826713:- | gene-YLR378C_AKU4011 | rna-NM_001182267.1_AKU4011 | cds-NP_013482.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:57450-58892:- | gene-YLR378C_BG1 | rna-NM_001182267.1_BG1 | cds-NP_013482.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:863605-865047:- | gene-YLR378C_Bruggeman | rna-NM_001182267.1_Bruggeman | cds-NP_013482.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:859101-860543:- | gene-YLR378C_CAT1 | rna-NM_001182267.1_CAT1 | cds-NP_013482.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:860865-862307:- | gene-YLR378C_CBS1585 | rna-NM_001182267.1_CBS1585 | cds-NP_013482.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:844508-845950:- | gene-YLR378C_CBS436 | rna-NM_001182267.1_CBS436 | cds-NP_013482.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:897287-898729:- | gene-YLR378C_CBS6412 | rna-NM_001182267.1_CBS6412 | cds-NP_013482.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:861156-862598:- | gene-YLR378C_CBS6413 | rna-NM_001182267.1_CBS6413 | cds-NP_013482.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:860508-861950:- | gene-YLR378C_CENPK1137D | rna-NM_001182267.1_CENPK1137D | cds-NP_013482.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:818030-819472:- | gene-YLR378C_EthanolRed | rna-NM_001182267.1_EthanolRed | cds-NP_013482.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:847153-848595:- | gene-YLR378C_FaliES1 | rna-NM_001182267.1_FaliES1 | cds-NP_013482.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:283-1725:- | gene-YLR378C_JAY291 | rna-NM_001182267.1_JAY291 | cds-NP_013482.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:861867-863309:- | gene-YLR378C_MUCL30387 | rna-NM_001182267.1_MUCL30387 | cds-NP_013482.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:868559-870001:- | gene-YLR378C_MUCL30388 | rna-NM_001182267.1_MUCL30388 | cds-NP_013482.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:862085-863527:- | gene-YLR378C_MUCL39482 | rna-NM_001182267.1_MUCL39482 | cds-NP_013482.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:856776-858218:- | gene-YLR378C_MUCL42920 | rna-NM_001182267.1_MUCL42920 | cds-NP_013482.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:875710-877152:- | gene-YLR378C_NCIM3186 | rna-NM_001182267.1_NCIM3186 | cds-NP_013482.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:871267-872709:- | gene-YLR378C_NCYC1407 | rna-NM_001182267.1_NCYC1407 | cds-NP_013482.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:857662-859104:- | gene-YLR378C_PE2H3 | rna-NM_001182267.1_PE2H3 | cds-NP_013482.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:857406-858848:- | gene-YLR378C_PE2H4 | rna-NM_001182267.1_PE2H4 | cds-NP_013482.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:875736-877178:- | gene-YLR378C_S288C | rna-NM_001182267.1_S288C | cds-NP_013482.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:171511-172953:+ | gene-YLR378C_SA1 | rna-NM_001182267.1_SA1 | cds-NP_013482.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:850232-851674:- | gene-YLR378C_ThermosaccDry | rna-NM_001182267.1_ThermosaccDry | cds-NP_013482.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:862752-864194:- | gene-YLR378C_VR1 | rna-NM_001182267.1_VR1 | cds-NP_013482.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:186920-188362:- | gene-YLR378C_ZTW1 | rna-NM_001182267.1_ZTW1 | cds-NP_013482.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:835655-837097:- | gene-YLR378C_Sparadoxus | rna-NM_001182267.1_Sparadoxus | cds-NP_013482.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |