Gene name: SEC3
Reference locus (S288C): YER008C
Gene biotype: protein_coding
Description: Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress; Belongs to the SEC3 family
Top 10 interactors (score): SEC8 (0.999); SEC5 (0.999); SEC6 (0.999); RHO1 (0.999); SEC10 (0.999); EXO84 (0.999); EXO70 (0.999); SEC15 (0.999); CDC42 (0.99); SSO2 (0.984); SEC4 (0.98); SEC9 (0.963); SEC1 (0.938); SRO7 (0.926); RHO3 (0.922); PFY1 (0.912); SEC2 (0.902); MYO2 (0.861); BNI1 (0.856); MSO1 (0.847)
Homologues (species, bitscore): KMT2D (Homo sapiens, 68.9); Kmt2d (Mus musculus, 76.6); crad (Danio rerio, 68.9); GIGYF2 (Xenopus tropicalis, 69.3); Dap160 (Drosophila melanogaster, 58.2); ttr-14 (Caenorhabditis elegans, 59.3); AT3G50370 (Arabidopsis thaliana, 51.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:161496-165506:- | gene-YER008C_AKU4011 | rna-NM_001178899.1_AKU4011 | cds-NP_010924.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:260177-264187:+ | gene-YER008C_BG1 | rna-NM_001178899.1_BG1 | cds-NP_010924.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:169184-173194:- | gene-YER008C_Bruggeman | rna-NM_001178899.1_Bruggeman | cds-NP_010924.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:164413-168423:- | gene-YER008C_CAT1 | rna-NM_001178899.1_CAT1 | cds-NP_010924.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:161805-165815:- | gene-YER008C_CBS1585 | rna-NM_001178899.1_CBS1585 | cds-NP_010924.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:163075-167085:- | gene-YER008C_CBS436 | rna-NM_001178899.1_CBS436 | cds-NP_010924.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:161699-165709:- | gene-YER008C_CBS6412 | rna-NM_001178899.1_CBS6412 | cds-NP_010924.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:166345-170355:- | gene-YER008C_CBS6413 | rna-NM_001178899.1_CBS6413 | cds-NP_010924.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:165634-169644:- | gene-YER008C_CENPK1137D | rna-NM_001178899.1_CENPK1137D | cds-NP_010924.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:162160-166170:- | gene-YER008C_EthanolRed | rna-NM_001178899.1_EthanolRed | cds-NP_010924.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:162420-166430:- | gene-YER008C_FaliES1 | rna-NM_001178899.1_FaliES1 | cds-NP_010924.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000024.1:29388-33398:- | gene-YER008C_JAY291 | rna-NM_001178899.1_JAY291 | cds-NP_010924.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:165721-169731:- | gene-YER008C_MUCL30387 | rna-NM_001178899.1_MUCL30387 | cds-NP_010924.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:162241-166251:- | gene-YER008C_MUCL30388 | rna-NM_001178899.1_MUCL30388 | cds-NP_010924.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:160841-164851:- | gene-YER008C_MUCL39482 | rna-NM_001178899.1_MUCL39482 | cds-NP_010924.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:166713-170723:- | gene-YER008C_MUCL42920 | rna-NM_001178899.1_MUCL42920 | cds-NP_010924.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:167807-171817:- | gene-YER008C_NCIM3186 | rna-NM_001178899.1_NCIM3186 | cds-NP_010924.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:165915-169925:- | gene-YER008C_NCYC1407 | rna-NM_001178899.1_NCYC1407 | cds-NP_010924.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:170215-174225:- | gene-YER008C_PE2H3 | rna-NM_001178899.1_PE2H3 | cds-NP_010924.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:166130-170140:- | gene-YER008C_PE2H4 | rna-NM_001178899.1_PE2H4 | cds-NP_010924.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:167808-171818:- | gene-YER008C_S288C | rna-NM_001178899.1_S288C | cds-NP_010924.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:71792-75802:+ | gene-YER008C_SA1 | rna-NM_001178899.1_SA1 | cds-NP_010924.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:162826-166836:- | gene-YER008C_ThermosaccDry | rna-NM_001178899.1_ThermosaccDry | cds-NP_010924.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:162306-166316:- | gene-YER008C_VR1 | rna-NM_001178899.1_VR1 | cds-NP_010924.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:160856-164866:- | gene-YER008C_ZTW1 | rna-NM_001178899.1_ZTW1 | cds-NP_010924.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:165581-169597:- | gene-YER008C_Sparadoxus | rna-NM_001178899.1_Sparadoxus | cds-NP_010924.1_Sparadoxus | 88.6 | 99.8 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |