Gene name: SEC12
Reference locus (S288C): YNR026C
Gene biotype: protein_coding
Description: Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication; Belongs to the WD repeat SEC12 family
Top 10 interactors (score): SAR1 (0.999); SEC16 (0.991); SEC31 (0.985); SEC23 (0.982); SEC13 (0.981); SEC24 (0.975); RER1 (0.955); SFB3 (0.91); SEC22 (0.906); SEC18 (0.885); SED4 (0.868); GRH1 (0.843); YPT1 (0.834); SEC21 (0.834); ERV29 (0.83); ERD2 (0.823); HRR25 (0.821); USO1 (0.821); SEC63 (0.806); YIP1 (0.806)
Homologues (species, bitscore): MFB16.9 (Arabidopsis thaliana, 63.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:656925-658340:- | gene-YNR026C_AKU4011 | rna-NM_001183203.1_AKU4011 | cds-NP_014423.1_AKU4011 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:564789-566204:- | gene-YNR026C_BG1 | rna-NM_001183203.1_BG1 | cds-NP_014423.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:674376-675791:- | gene-YNR026C_Bruggeman | rna-NM_001183203.1_Bruggeman | cds-NP_014423.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:708634-710049:- | gene-YNR026C_CAT1 | rna-NM_001183203.1_CAT1 | cds-NP_014423.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:662680-664095:- | gene-YNR026C_CBS1585 | rna-NM_001183203.1_CBS1585 | cds-NP_014423.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:724348-725763:- | gene-YNR026C_CBS436 | rna-NM_001183203.1_CBS436 | cds-NP_014423.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:651868-653283:- | gene-YNR026C_CBS6412 | rna-NM_001183203.1_CBS6412 | cds-NP_014423.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:653573-654988:- | gene-YNR026C_CBS6413 | rna-NM_001183203.1_CBS6413 | cds-NP_014423.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:667027-668442:- | gene-YNR026C_CENPK1137D | rna-NM_001183203.1_CENPK1137D | cds-NP_014423.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:658617-660032:- | gene-YNR026C_EthanolRed | rna-NM_001183203.1_EthanolRed | cds-NP_014423.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:649820-651235:- | gene-YNR026C_FaliES1 | rna-NM_001183203.1_FaliES1 | cds-NP_014423.1_FaliES1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000037.1:51546-52961:+ | gene-YNR026C_JAY291 | rna-NM_001183203.1_JAY291 | cds-NP_014423.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:672133-673548:- | gene-YNR026C_MUCL30387 | rna-NM_001183203.1_MUCL30387 | cds-NP_014423.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:712956-714371:- | gene-YNR026C_MUCL30388 | rna-NM_001183203.1_MUCL30388 | cds-NP_014423.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:654180-655595:- | gene-YNR026C_MUCL39482 | rna-NM_001183203.1_MUCL39482 | cds-NP_014423.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:658350-659765:- | gene-YNR026C_MUCL42920 | rna-NM_001183203.1_MUCL42920 | cds-NP_014423.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:673243-674658:- | gene-YNR026C_NCIM3186 | rna-NM_001183203.1_NCIM3186 | cds-NP_014423.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:656688-658103:- | gene-YNR026C_NCYC1407 | rna-NM_001183203.1_NCYC1407 | cds-NP_014423.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:657775-659190:- | gene-YNR026C_PE2H3 | rna-NM_001183203.1_PE2H3 | cds-NP_014423.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:659093-660508:- | gene-YNR026C_PE2H4 | rna-NM_001183203.1_PE2H4 | cds-NP_014423.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:673274-674689:- | gene-YNR026C_S288C | rna-NM_001183203.1_S288C | cds-NP_014423.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000074.1:51696-53111:+ | gene-YNR026C_SA1 | rna-NM_001183203.1_SA1 | cds-NP_014423.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:650157-651572:- | gene-YNR026C_ThermosaccDry | rna-NM_001183203.1_ThermosaccDry | cds-NP_014423.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:692154-693569:- | gene-YNR026C_VR1 | rna-NM_001183203.1_VR1 | cds-NP_014423.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:559568-560983:- | gene-YNR026C_ZTW1 | rna-NM_001183203.1_ZTW1 | cds-NP_014423.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:664256-665671:- | gene-YNR026C_Sparadoxus | rna-NM_001183203.1_Sparadoxus | cds-NP_014423.1_Sparadoxus | 89.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |