Gene name: SEA4
Reference locus (S288C): YBL104C
Gene biotype: protein_coding
Description: Wd repeat-containing protein mio; SEH-associated protein 4; Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif
Top 10 interactors (score): SEC13 (0.999); IML1 (0.999); NPR2 (0.999); RTC1 (0.999); SEH1 (0.999); MTC5 (0.999); NPR3 (0.983); LST7 (0.962); GTR1 (0.895); GTR2 (0.891); LST4 (0.842); SCS7 (0.767); VAM6 (0.762); RRB1 (0.732); RHB1 (0.725); VMA1 (0.719); MEH1 (0.705); SLM4 (0.699); SKG1 (0.693); EGO2 (0.692)
Homologues (species, bitscore): MIOS (Homo sapiens, 247.3); Mios (Mus musculus, 241.5); mios (Danio rerio, 229.9); mios (Xenopus tropicalis, 233.4); mio (Drosophila melanogaster, 191.0); F39C12.1 (Caenorhabditis elegans, 61.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:18074-21190:- | gene-YBL104C_AKU4011 | rna-NM_001178344.1_AKU4011 | cds-NP_009446.2_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:8798-11914:- | gene-YBL104C_BG1 | rna-NM_001178344.1_BG1 | cds-NP_009446.2_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:18458-21574:- | gene-YBL104C_Bruggeman | rna-NM_001178344.1_Bruggeman | cds-NP_009446.2_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:20664-23780:- | gene-YBL104C_CAT1 | rna-NM_001178344.1_CAT1 | cds-NP_009446.2_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:10145-13261:- | gene-YBL104C_CBS1585 | rna-NM_001178344.1_CBS1585 | cds-NP_009446.2_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:13097-16213:- | gene-YBL104C_CBS436 | rna-NM_001178344.1_CBS436 | cds-NP_009446.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:9933-13049:- | gene-YBL104C_CBS6412 | rna-NM_001178344.1_CBS6412 | cds-NP_009446.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:16275-19391:- | gene-YBL104C_CBS6413 | rna-NM_001178344.1_CBS6413 | cds-NP_009446.2_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:12109-15225:- | gene-YBL104C_CENPK1137D | rna-NM_001178344.1_CENPK1137D | cds-NP_009446.2_CENPK1137D | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:32317-35433:- | gene-YBL104C_EthanolRed | rna-NM_001178344.1_EthanolRed | cds-NP_009446.2_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:32449-35565:- | gene-YBL104C_FaliES1 | rna-NM_001178344.1_FaliES1 | cds-NP_009446.2_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000184.1:9491-12607:- | gene-YBL104C_JAY291 | rna-NM_001178344.1_JAY291 | cds-NP_009446.2_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:17601-20717:- | gene-YBL104C_MUCL30387 | rna-NM_001178344.1_MUCL30387 | cds-NP_009446.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:17703-20819:- | gene-YBL104C_MUCL30388 | rna-NM_001178344.1_MUCL30388 | cds-NP_009446.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:10301-13417:- | gene-YBL104C_MUCL39482 | rna-NM_001178344.1_MUCL39482 | cds-NP_009446.2_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:16940-20056:- | gene-YBL104C_MUCL42920 | rna-NM_001178344.1_MUCL42920 | cds-NP_009446.2_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:17974-21090:- | gene-YBL104C_NCIM3186 | rna-NM_001178344.1_NCIM3186 | cds-NP_009446.2_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:11973-15089:- | gene-YBL104C_NCYC1407 | rna-NM_001178344.1_NCYC1407 | cds-NP_009446.2_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:18281-21397:- | gene-YBL104C_PE2H3 | rna-NM_001178344.1_PE2H3 | cds-NP_009446.2_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:15913-19029:- | gene-YBL104C_PE2H4 | rna-NM_001178344.1_PE2H4 | cds-NP_009446.2_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:18177-21293:- | gene-YBL104C_S288C | rna-NM_001178344.1_S288C | cds-NP_009446.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:8596-11712:- | gene-YBL104C_SA1 | rna-NM_001178344.1_SA1 | cds-NP_009446.2_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:32411-35527:- | gene-YBL104C_ThermosaccDry | rna-NM_001178344.1_ThermosaccDry | cds-NP_009446.2_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:14626-17742:- | gene-YBL104C_VR1 | rna-NM_001178344.1_VR1 | cds-NP_009446.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:9636-12752:- | gene-YBL104C_ZTW1 | rna-NM_001178344.1_ZTW1 | cds-NP_009446.2_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:44562-47678:- | gene-YBL104C_Sparadoxus | rna-NM_001178344.1_Sparadoxus | cds-NP_009446.2_Sparadoxus | 90.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |