Gene name: SCS22
Reference locus (S288C): YBL091C-A
Gene biotype: protein_coding
Description: Vesicle-associated membrane protein-associated protein SCS22; Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family
Top 10 interactors (score): TCB1 (0.919); PCT1 (0.909); CPT1 (0.909); IST2 (0.898); INO1 (0.85); OSH3 (0.813); TCB2 (0.811); TCB3 (0.81); SAC1 (0.761); YLR031W (0.749); OSH2 (0.715); NUM1 (0.68); ECM9 (0.614); RRT8 (0.574); YET1 (0.564); NVJ2 (0.563); NIP100 (0.517); EPO1 (0.499); OPI1 (0.499); SAE3 (0.487)
Homologues (species, bitscore): VAPA (Homo sapiens, 61.6); Vapa (Mus musculus, 60.8); vapal (Danio rerio, 63.2); vapa (Xenopus tropicalis, 58.5); Vap-33A (Drosophila melanogaster, 52.0); vpr-1 (Caenorhabditis elegans, 62.8); VAP27-2 (Arabidopsis thaliana, 56.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:40110-40725:- | gene-YBL091C-A_AKU4011 | rna-NM_001184321.1_AKU4011 | cds-NP_009461.2_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:30807-31422:- | gene-YBL091C-A_BG1 | rna-NM_001184321.1_BG1 | cds-NP_009461.2_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:40737-41352:- | gene-YBL091C-A_Bruggeman | rna-NM_001184321.1_Bruggeman | cds-NP_009461.2_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:42665-43280:- | gene-YBL091C-A_CAT1 | rna-NM_001184321.1_CAT1 | cds-NP_009461.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:32192-32807:- | gene-YBL091C-A_CBS1585 | rna-NM_001184321.1_CBS1585 | cds-NP_009461.2_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:40998-41613:- | gene-YBL091C-A_CBS436 | rna-NM_001184321.1_CBS436 | cds-NP_009461.2_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:31983-32598:- | gene-YBL091C-A_CBS6412 | rna-NM_001184321.1_CBS6412 | cds-NP_009461.2_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:38270-38885:- | gene-YBL091C-A_CBS6413 | rna-NM_001184321.1_CBS6413 | cds-NP_009461.2_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:40220-40835:- | gene-YBL091C-A_CENPK1137D | rna-NM_001184321.1_CENPK1137D | cds-NP_009461.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:54363-54978:- | gene-YBL091C-A_EthanolRed | rna-NM_001184321.1_EthanolRed | cds-NP_009461.2_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:54492-55107:- | gene-YBL091C-A_FaliES1 | rna-NM_001184321.1_FaliES1 | cds-NP_009461.2_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000184.1:31530-32145:- | gene-YBL091C-A_JAY291 | rna-NM_001184321.1_JAY291 | cds-NP_009461.2_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:39878-40493:- | gene-YBL091C-A_MUCL30387 | rna-NM_001184321.1_MUCL30387 | cds-NP_009461.2_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:40550-41165:- | gene-YBL091C-A_MUCL30388 | rna-NM_001184321.1_MUCL30388 | cds-NP_009461.2_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:32342-32957:- | gene-YBL091C-A_MUCL39482 | rna-NM_001184321.1_MUCL39482 | cds-NP_009461.2_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:39217-39832:- | gene-YBL091C-A_MUCL42920 | rna-NM_001184321.1_MUCL42920 | cds-NP_009461.2_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:46362-46977:- | gene-YBL091C-A_NCIM3186 | rna-NM_001184321.1_NCIM3186 | cds-NP_009461.2_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:34018-34633:- | gene-YBL091C-A_NCYC1407 | rna-NM_001184321.1_NCYC1407 | cds-NP_009461.2_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:40327-40942:- | gene-YBL091C-A_PE2H3 | rna-NM_001184321.1_PE2H3 | cds-NP_009461.2_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:37969-38584:- | gene-YBL091C-A_PE2H4 | rna-NM_001184321.1_PE2H4 | cds-NP_009461.2_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:46565-47180:- | gene-YBL091C-A_S288C | rna-NM_001184321.1_S288C | cds-NP_009461.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:30671-31286:- | gene-YBL091C-A_SA1 | rna-NM_001184321.1_SA1 | cds-NP_009461.2_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:54453-55068:- | gene-YBL091C-A_ThermosaccDry | rna-NM_001184321.1_ThermosaccDry | cds-NP_009461.2_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:36655-37270:- | gene-YBL091C-A_VR1 | rna-NM_001184321.1_VR1 | cds-NP_009461.2_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:31674-32289:- | gene-YBL091C-A_ZTW1 | rna-NM_001184321.1_ZTW1 | cds-NP_009461.2_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:66412-67030:- | gene-YBL091C-A_Sparadoxus | rna-NM_001184321.1_Sparadoxus | cds-NP_009461.2_Sparadoxus | 86.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |