Gene name: SCS2
Reference locus (S288C): YER120W
Gene biotype: protein_coding
Description: Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family
Top 10 interactors (score): OSH3 (0.998); OPI1 (0.998); OSH2 (0.994); SWH1 (0.992); SAC1 (0.977); STT4 (0.975); IST2 (0.971); EPO1 (0.963); SHS1 (0.954); TCB1 (0.944); PCT1 (0.938); CPT1 (0.924); ICE2 (0.923); NUM1 (0.922); INO1 (0.912); RTN1 (0.91); PAH1 (0.908); YET3 (0.88); TCB3 (0.876); YOP1 (0.867)
Homologues (species, bitscore): VAPA (Homo sapiens, 70.9); Vapa (Mus musculus, 69.7); vapb (Danio rerio, 71.2); vapa (Xenopus tropicalis, 65.1); Vap-33A (Drosophila melanogaster, 64.3); vpr-1 (Caenorhabditis elegans, 62.8); VAP27-2 (Arabidopsis thaliana, 75.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:395011-395745:+ | gene-YER120W_AKU4011 | rna-NM_001179010.3_AKU4011 | cds-NP_011046.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:29877-30611:- | gene-YER120W_BG1 | rna-NM_001179010.3_BG1 | cds-NP_011046.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:405481-406215:+ | gene-YER120W_Bruggeman | rna-NM_001179010.3_Bruggeman | cds-NP_011046.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:400723-401457:+ | gene-YER120W_CAT1 | rna-NM_001179010.3_CAT1 | cds-NP_011046.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:394406-395140:+ | gene-YER120W_CBS1585 | rna-NM_001179010.3_CBS1585 | cds-NP_011046.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:397112-397846:+ | gene-YER120W_CBS436 | rna-NM_001179010.3_CBS436 | cds-NP_011046.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:393484-394218:+ | gene-YER120W_CBS6412 | rna-NM_001179010.3_CBS6412 | cds-NP_011046.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:400328-401062:+ | gene-YER120W_CBS6413 | rna-NM_001179010.3_CBS6413 | cds-NP_011046.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:398871-399605:+ | gene-YER120W_CENPK1137D | rna-NM_001179010.3_CENPK1137D | cds-NP_011046.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:394860-395594:+ | gene-YER120W_EthanolRed | rna-NM_001179010.3_EthanolRed | cds-NP_011046.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:395341-396075:+ | gene-YER120W_FaliES1 | rna-NM_001179010.3_FaliES1 | cds-NP_011046.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000028.1:3560-4294:+ | gene-YER120W_JAY291 | rna-NM_001179010.3_JAY291 | cds-NP_011046.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:402429-403163:+ | gene-YER120W_MUCL30387 | rna-NM_001179010.3_MUCL30387 | cds-NP_011046.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:397375-398109:+ | gene-YER120W_MUCL30388 | rna-NM_001179010.3_MUCL30388 | cds-NP_011046.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:393431-394165:+ | gene-YER120W_MUCL39482 | rna-NM_001179010.3_MUCL39482 | cds-NP_011046.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:401921-402655:+ | gene-YER120W_MUCL42920 | rna-NM_001179010.3_MUCL42920 | cds-NP_011046.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:401134-401868:+ | gene-YER120W_NCIM3186 | rna-NM_001179010.3_NCIM3186 | cds-NP_011046.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:398964-399698:+ | gene-YER120W_NCYC1407 | rna-NM_001179010.3_NCYC1407 | cds-NP_011046.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:409509-410243:+ | gene-YER120W_PE2H3 | rna-NM_001179010.3_PE2H3 | cds-NP_011046.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:399450-400184:+ | gene-YER120W_PE2H4 | rna-NM_001179010.3_PE2H4 | cds-NP_011046.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:401135-401869:+ | gene-YER120W_S288C | rna-NM_001179010.3_S288C | cds-NP_011046.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:110741-111475:+ | gene-YER120W_SA1 | rna-NM_001179010.3_SA1 | cds-NP_011046.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:396139-396873:+ | gene-YER120W_ThermosaccDry | rna-NM_001179010.3_ThermosaccDry | cds-NP_011046.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:397193-397927:+ | gene-YER120W_VR1 | rna-NM_001179010.3_VR1 | cds-NP_011046.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:393247-394008:+ | gene-YER120W_ZTW1 | rna-NM_001179010.3_ZTW1 | cds-NP_011046.3_ZTW1 | 96.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:397201-397935:+ | gene-YER120W_Sparadoxus | rna-NM_001179010.3_Sparadoxus | cds-NP_011046.3_Sparadoxus | 93.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |