SCS2 (YER120W)


Gene profile

Gene name: SCS2
Reference locus (S288C): YER120W
Gene biotype: protein_coding

Description: Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family

Top 10 interactors (score): OSH3 (0.998); OPI1 (0.998); OSH2 (0.994); SWH1 (0.992); SAC1 (0.977); STT4 (0.975); IST2 (0.971); EPO1 (0.963); SHS1 (0.954); TCB1 (0.944); PCT1 (0.938); CPT1 (0.924); ICE2 (0.923); NUM1 (0.922); INO1 (0.912); RTN1 (0.91); PAH1 (0.908); YET3 (0.88); TCB3 (0.876); YOP1 (0.867)

Homologues (species, bitscore): VAPA (Homo sapiens, 70.9); Vapa (Mus musculus, 69.7); vapb (Danio rerio, 71.2); vapa (Xenopus tropicalis, 65.1); Vap-33A (Drosophila melanogaster, 64.3); vpr-1 (Caenorhabditis elegans, 62.8); VAP27-2 (Arabidopsis thaliana, 75.1)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005299.1:395011-395745:+ gene-YER120W_AKU4011 rna-NM_001179010.3_AKU4011 cds-NP_011046.3_AKU4011 99.7 100.0 Verified 1 1 1 True True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000011.1:29877-30611:- gene-YER120W_BG1 rna-NM_001179010.3_BG1 cds-NP_011046.3_BG1 99.8 100.0 Verified 1 1 1 True True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005507.1:405481-406215:+ gene-YER120W_Bruggeman rna-NM_001179010.3_Bruggeman cds-NP_011046.3_Bruggeman 99.8 100.0 Verified 1 1 1 True True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005523.1:400723-401457:+ gene-YER120W_CAT1 rna-NM_001179010.3_CAT1 cds-NP_011046.3_CAT1 99.7 100.0 Verified 1 1 1 True True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005363.1:394406-395140:+ gene-YER120W_CBS1585 rna-NM_001179010.3_CBS1585 cds-NP_011046.3_CBS1585 99.7 100.0 Verified 1 1 1 True True False False False
CBS436 GCA_001738355.1 Sake Asia CM005347.1:397112-397846:+ gene-YER120W_CBS436 rna-NM_001179010.3_CBS436 cds-NP_011046.3_CBS436 99.8 100.0 Mismatch 1 1 1 True True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005331.1:393484-394218:+ gene-YER120W_CBS6412 rna-NM_001179010.3_CBS6412 cds-NP_011046.3_CBS6412 99.7 100.0 Mismatch 1 1 1 True True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005315.1:400328-401062:+ gene-YER120W_CBS6413 rna-NM_001179010.3_CBS6413 cds-NP_011046.3_CBS6413 99.7 100.0 Verified 1 1 1 True True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001526.1:398871-399605:+ gene-YER120W_CENPK1137D rna-NM_001179010.3_CENPK1137D cds-NP_011046.3_CENPK1137D 99.7 100.0 Verified 1 1 1 True True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005475.1:394860-395594:+ gene-YER120W_EthanolRed rna-NM_001179010.3_EthanolRed cds-NP_011046.3_EthanolRed 99.8 100.0 Verified 1 1 1 True True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005539.1:395341-396075:+ gene-YER120W_FaliES1 rna-NM_001179010.3_FaliES1 cds-NP_011046.3_FaliES1 99.8 100.0 Verified 1 1 1 True True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000028.1:3560-4294:+ gene-YER120W_JAY291 rna-NM_001179010.3_JAY291 cds-NP_011046.3_JAY291 99.7 100.0 Verified 1 1 1 True True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005411.1:402429-403163:+ gene-YER120W_MUCL30387 rna-NM_001179010.3_MUCL30387 cds-NP_011046.3_MUCL30387 99.8 100.0 Verified 1 1 1 True True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005443.1:397375-398109:+ gene-YER120W_MUCL30388 rna-NM_001179010.3_MUCL30388 cds-NP_011046.3_MUCL30388 99.8 100.0 Verified 1 1 1 True True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005283.1:393431-394165:+ gene-YER120W_MUCL39482 rna-NM_001179010.3_MUCL39482 cds-NP_011046.3_MUCL39482 99.7 100.0 Verified 1 1 1 True True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005427.1:401921-402655:+ gene-YER120W_MUCL42920 rna-NM_001179010.3_MUCL42920 cds-NP_011046.3_MUCL42920 99.7 100.0 Verified 1 1 1 False True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011814.1:401134-401868:+ gene-YER120W_NCIM3186 rna-NM_001179010.3_NCIM3186 cds-NP_011046.3_NCIM3186 99.8 100.0 Verified 1 1 1 True True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005267.1:398964-399698:+ gene-YER120W_NCYC1407 rna-NM_001179010.3_NCYC1407 cds-NP_011046.3_NCYC1407 99.7 100.0 Verified 1 1 1 True True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994144.1:409509-410243:+ gene-YER120W_PE2H3 rna-NM_001179010.3_PE2H3 cds-NP_011046.3_PE2H3 99.7 100.0 Verified 1 1 1 True True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999876.1:399450-400184:+ gene-YER120W_PE2H4 rna-NM_001179010.3_PE2H4 cds-NP_011046.3_PE2H4 99.7 100.0 Verified 1 1 1 True True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001137.3:401135-401869:+ gene-YER120W_S288C rna-NM_001179010.3_S288C cds-NP_011046.3_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000023.1:110741-111475:+ gene-YER120W_SA1 rna-NM_001179010.3_SA1 cds-NP_011046.3_SA1 99.7 100.0 Verified 1 1 1 True True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005491.1:396139-396873:+ gene-YER120W_ThermosaccDry rna-NM_001179010.3_ThermosaccDry cds-NP_011046.3_ThermosaccDry 99.8 100.0 Verified 1 1 1 True True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005459.1:397193-397927:+ gene-YER120W_VR1 rna-NM_001179010.3_VR1 cds-NP_011046.3_VR1 99.7 100.0 Verified 1 1 1 True True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000009.1:393247-394008:+ gene-YER120W_ZTW1 rna-NM_001179010.3_ZTW1 cds-NP_011046.3_ZTW1 96.3 100.0 Verified 1 1 1 False True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047491.1:397201-397935:+ gene-YER120W_Sparadoxus rna-NM_001179010.3_Sparadoxus cds-NP_011046.3_Sparadoxus 93.4 100.0 Verified 1 1 1 False True False False False

Additional files